Patents Assigned to Iowa Health System
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Patent number: 9474801Abstract: The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor cells are engineered to express an ?(1,3)galactosyl epitope. The cells are then irradiated or otherwise killed and administered to a patient. The ? galactosyl epitope causes opsonization of the tumor cell enhancing uptake of the opsonized tumor cell by antigen presenting cells which results in enhanced tumor specific antigen presentation. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.Type: GrantFiled: August 14, 2013Date of Patent: October 25, 2016Assignee: CENTRAL IOWA HEALTH SYSTEMInventors: Charles J. Link, Jr., Tatiana Seregina, Gabriela Rossi
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Patent number: 9474771Abstract: The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor cells are engineered to express an ?(1,3)galactosyl epitope. The cells are then irradiated or otherwise killed and administered to a patient. The ?-galactosyl epitope causes opsonization of the tumor cell enhancing uptake of the opsonized tumor cell by antigen presenting cells which results in enhanced tumor specific antigen presentation. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.Type: GrantFiled: August 28, 2013Date of Patent: October 25, 2016Assignee: CENTRAL IOWA HEALTH SYSTEMInventors: Charles J. Link, Jr., Tatiana Seregina, Gabriela Rossi
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Publication number: 20140072597Abstract: The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor cells are engineered to express an ?(1,3)galactosyl epitope. The cells are then irradiated or otherwise killed and administered to a patient. The ?-galactosyl epitope causes opsonization of the tumor cell enhancing uptake of the opsonized tumor cell by antigen presenting cells which results in enhanced tumor specific antigen presentation. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.Type: ApplicationFiled: August 28, 2013Publication date: March 13, 2014Applicant: Central Iowa Health SystemInventors: Charles J. LINK, JR., Tatiana Seregina, Gabriela Rossi
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Publication number: 20140037692Abstract: The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor cells are engineered to express an ?(1,3)galactosyl epitope. The cells are then irradiated or otherwise killed and administered to a patient. The ? galactosyl epitope causes opsonization of the tumor cell enhancing uptake of the opsonized tumor cell by antigen presenting cells which results in enhanced tumor specific antigen presentation. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.Type: ApplicationFiled: August 14, 2013Publication date: February 6, 2014Applicant: CENTRAL IOWA HEALTH SYSTEMInventors: Charles J. LINK, JR., Tatiana Seregina, Gabriela Rossi
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Patent number: 8551474Abstract: The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor cells are engineered to express an ?(1,3)galactosyl epitope. The cells are then irradiated or otherwise killed and administered to a patient. The ?-galactosyl epitope causes opsonization of the tumor cell enhancing uptake of the opsonized tumor cell by antigen presenting cells which results in enhanced tumor specific antigen presentation. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.Type: GrantFiled: September 24, 2010Date of Patent: October 8, 2013Assignee: Central Iowa Health SystemInventors: Charles J. Link, Jr., Tatiana Seregina, Gabriela Rossi
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Patent number: 8535658Abstract: The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor cells are engineered to express an ? (1,3) galactosyl epitope. The cells are then irradiated or otherwise killed and administered to a patient. The ? galactosyl epitope causes opsonization of the tumor cell enhancing uptake of the opsonized tumor cell by antigen presenting cells which results in enhanced tumor specific antigen presentation. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.Type: GrantFiled: September 9, 2010Date of Patent: September 17, 2013Assignee: Central Iowa Health SystemInventors: Charles J. Link, Jr., Tatiana Seregina, Gabriela Rossi
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Publication number: 20110086067Abstract: The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor cells are engineered to express an ?(1,3)galactosyl epitope. The cells are then irradiated or otherwise killed and administered to a patient. The ?-galactosyl epitope causes opsonization of the tumor cell enhancing uptake of the opsonized tumor cell by antigen presenting cells which results in enhanced tumor specific antigen presentation. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.Type: ApplicationFiled: September 24, 2010Publication date: April 14, 2011Applicant: Central Iowa Health SystemInventors: Charles J. LINK, JR., Tatiana Seregina, Gabriela Rossi
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Patent number: 7763461Abstract: The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor cells are engineered to express an ? (1,3) galactosyl epitope. The cells are then irradiated or otherwise killed and administered to a patient. The ? galactosyl epitope causes opsonization of the tumor cell enhancing uptake of the opsonized tumor cell by antigen presenting cells which results in enhanced tumor specific antigen presentation. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.Type: GrantFiled: September 19, 2006Date of Patent: July 27, 2010Assignee: Iowa Health SystemInventors: Charles J. Link, Jr., Tatiana Seregina, Gabriela Rossi
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Patent number: 5505412Abstract: An arm board for removable placement on wheel chair arms. The platform of the arm board upon which the wheel chair users arm rests is premanufactured to have multiple mounting locations for mounting members to the wheel chair arm. It therefore can be interchanged between left and right wheel chair arms. According to another aspect of the invention, the board can be slid over a wheel chair arm and arm rest, by utilizing a mounting bracket combination, without removing the arm rest.Type: GrantFiled: May 27, 1994Date of Patent: April 9, 1996Assignee: Iowa Health SystemInventor: Eugene P. Van Hamme