Patents Assigned to Iowa Health System
  • Patent number: 9474801
    Abstract: The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor cells are engineered to express an ?(1,3)galactosyl epitope. The cells are then irradiated or otherwise killed and administered to a patient. The ? galactosyl epitope causes opsonization of the tumor cell enhancing uptake of the opsonized tumor cell by antigen presenting cells which results in enhanced tumor specific antigen presentation. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.
    Type: Grant
    Filed: August 14, 2013
    Date of Patent: October 25, 2016
    Assignee: CENTRAL IOWA HEALTH SYSTEM
    Inventors: Charles J. Link, Jr., Tatiana Seregina, Gabriela Rossi
  • Patent number: 9474771
    Abstract: The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor cells are engineered to express an ?(1,3)galactosyl epitope. The cells are then irradiated or otherwise killed and administered to a patient. The ?-galactosyl epitope causes opsonization of the tumor cell enhancing uptake of the opsonized tumor cell by antigen presenting cells which results in enhanced tumor specific antigen presentation. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: October 25, 2016
    Assignee: CENTRAL IOWA HEALTH SYSTEM
    Inventors: Charles J. Link, Jr., Tatiana Seregina, Gabriela Rossi
  • Publication number: 20140072597
    Abstract: The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor cells are engineered to express an ?(1,3)galactosyl epitope. The cells are then irradiated or otherwise killed and administered to a patient. The ?-galactosyl epitope causes opsonization of the tumor cell enhancing uptake of the opsonized tumor cell by antigen presenting cells which results in enhanced tumor specific antigen presentation. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.
    Type: Application
    Filed: August 28, 2013
    Publication date: March 13, 2014
    Applicant: Central Iowa Health System
    Inventors: Charles J. LINK, JR., Tatiana Seregina, Gabriela Rossi
  • Publication number: 20140037692
    Abstract: The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor cells are engineered to express an ?(1,3)galactosyl epitope. The cells are then irradiated or otherwise killed and administered to a patient. The ? galactosyl epitope causes opsonization of the tumor cell enhancing uptake of the opsonized tumor cell by antigen presenting cells which results in enhanced tumor specific antigen presentation. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.
    Type: Application
    Filed: August 14, 2013
    Publication date: February 6, 2014
    Applicant: CENTRAL IOWA HEALTH SYSTEM
    Inventors: Charles J. LINK, JR., Tatiana Seregina, Gabriela Rossi
  • Patent number: 8551474
    Abstract: The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor cells are engineered to express an ?(1,3)galactosyl epitope. The cells are then irradiated or otherwise killed and administered to a patient. The ?-galactosyl epitope causes opsonization of the tumor cell enhancing uptake of the opsonized tumor cell by antigen presenting cells which results in enhanced tumor specific antigen presentation. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: October 8, 2013
    Assignee: Central Iowa Health System
    Inventors: Charles J. Link, Jr., Tatiana Seregina, Gabriela Rossi
  • Patent number: 8535658
    Abstract: The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor cells are engineered to express an ? (1,3) galactosyl epitope. The cells are then irradiated or otherwise killed and administered to a patient. The ? galactosyl epitope causes opsonization of the tumor cell enhancing uptake of the opsonized tumor cell by antigen presenting cells which results in enhanced tumor specific antigen presentation. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: September 17, 2013
    Assignee: Central Iowa Health System
    Inventors: Charles J. Link, Jr., Tatiana Seregina, Gabriela Rossi
  • Publication number: 20110086067
    Abstract: The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor cells are engineered to express an ?(1,3)galactosyl epitope. The cells are then irradiated or otherwise killed and administered to a patient. The ?-galactosyl epitope causes opsonization of the tumor cell enhancing uptake of the opsonized tumor cell by antigen presenting cells which results in enhanced tumor specific antigen presentation. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.
    Type: Application
    Filed: September 24, 2010
    Publication date: April 14, 2011
    Applicant: Central Iowa Health System
    Inventors: Charles J. LINK, JR., Tatiana Seregina, Gabriela Rossi
  • Patent number: 7763461
    Abstract: The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor cells are engineered to express an ? (1,3) galactosyl epitope. The cells are then irradiated or otherwise killed and administered to a patient. The ? galactosyl epitope causes opsonization of the tumor cell enhancing uptake of the opsonized tumor cell by antigen presenting cells which results in enhanced tumor specific antigen presentation. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.
    Type: Grant
    Filed: September 19, 2006
    Date of Patent: July 27, 2010
    Assignee: Iowa Health System
    Inventors: Charles J. Link, Jr., Tatiana Seregina, Gabriela Rossi
  • Patent number: 5505412
    Abstract: An arm board for removable placement on wheel chair arms. The platform of the arm board upon which the wheel chair users arm rests is premanufactured to have multiple mounting locations for mounting members to the wheel chair arm. It therefore can be interchanged between left and right wheel chair arms. According to another aspect of the invention, the board can be slid over a wheel chair arm and arm rest, by utilizing a mounting bracket combination, without removing the arm rest.
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: April 9, 1996
    Assignee: Iowa Health System
    Inventor: Eugene P. Van Hamme