Patents Assigned to Iowa Immunotherapy Investigators
  • Humanized antibodies against CD3
    Patent number: 7381803
    Abstract: The invention provides bispecific antibodies with selective cytotoxicity against malignant B-cells. The bispecific antibodies bind to an effector cell antigen and to a 28/32 kDa heterodimeric protein on the surface of malignant B-cells. The invention also includes the monospecific components of the bispecific antibodies, humanized versions thereof, and humanized bispecific antibodies. The invention further provides therapeutic and diagnostic methods employing these antibodies.
    Type: Grant
    Filed: July 18, 2000
    Date of Patent: June 3, 2008
    Assignees: PDL BioPharma, Inc., Iowa Immunotherapy Investigators
    Inventors: George Weiner, Roger Gingrich, Brian K. Link, J. Yun Tso
  • HUMANIZED ANTIBODIES AGAINST CD3
    Publication number: 20080025975
    Abstract: The invention provides bispecific antibodies with selective cytotoxicity against malignant B-cells. The bispecific antibodies bind to an effector cell antigen and to a 28/32 kDa heterodimeric protein on the surface of malignant B-cells. The invention also includes the monospecific components of the bispecific antibodies, humanized versions thereof, and humanized bispecific antibodies. The invention further provides therapeutic and diagnostic methods employing these antibodies.
    Type: Application
    Filed: March 26, 2007
    Publication date: January 31, 2008
    Applicants: Protein Design Labs, Inc., Iowa Immunotherapy Investigators
    Inventors: George Weiner, Roger Gingrich, Brian Link, J. Tso
  • Humanized antibodies against CD3
    Publication number: 20040052783
    Abstract: The invention provides bispecific antibodies with selective cytotoxicity against malignant B-cells. The bispecific antibodies bind to an effector cell antigen and to a 28/32 kDa heterodimeric protein on the surface of malignant B-cells. The invention also includes the monospecific components of the bispecific antibodies, humanized versions thereof, and humanized bispecific antibodies. The invention further provides therapeutic and diagnostic methods employing these antibodies.
    Type: Application
    Filed: May 9, 2003
    Publication date: March 18, 2004
    Applicants: Protein Design Labs, Inc., Iowa Immunotherapy Investigators
    Inventors: George Weiner, Roger Gingrich, Brian K. Link, J. Yun Tso