Abstract: Provided is an isolated antibody that specifically binds to HPA-1a. Also provided is a nucleic acid molecule that encodes the antibody, and compositions comprising the antibody. Also provided is a method of producing the antibody and methods and uses which employ the antibody. Also provided are therapeutic uses of the antibody, for example in the treatment or prophylaxis of fetal and neonatal alloimmune thrombocytopenia (FNAIT).

Abstract: A front bolster and frame connection system for an intermodal chassis including a front bolster, a front gooseneck frame extending from the intermodal chassis having beams, mounting tabs attached to the front bolster, mounting tabs attached to the front gooseneck frame, a front gooseneck frame mounting plate welded to the end of the front end of the front gooseneck frame, and angle braces attached to the mounting tabs. The angle braces connect the bolt on front bolster and the front gooseneck frame. A retrofit kit and an alternate embodiment are also provided. The bolt on front bolster design of the present invention requires minimal cutting or grinding to remove and minimal welding to replace. The bolt on front bolster adds considerable value to operators in the intermodal market by facilitating service and eliminating chronic issues.

Abstract: An intermodal shipping container including one or more improvements such as intermediate gable posts or gable headers adapted to increase an internal width and strength of the container, wherein the gable posts or the gable headers include twin channels having at least two internal flanges welded to a gable post plate or gable header plate, one or more upper castings having an integral top rail ledge, wherein a top rail of a side wall hangs on the integral top rail ledge, “C” channel style beam main frame cross members, a one-piece continuous top plate including an integral lip connecting the top plate and a roof, one or more rear lower castings, wherein the one or more rear lower castings are an integral interlocking interface, a bolster including an integral seating and fastening surface and slots, and/or one or more nested rear corner posts subassemblies, the one or more nested rear corner posts having a notch and protrusion connection, wherein a protrusion in a lower rear casting engages with a correspond

Abstract: The present invention provides an isolated antibody that specifically binds to HPA-1a. Also provided is a nucleic acid molecule that encodes the antibody, and compositions comprising the antibody. Also provided is a method of producing the antibody and methods and uses which employ the antibody. Also provided are therapeutic uses of the antibody, for example in the treatment or prophylaxis of fetal and neonatal alloimmune thrombocytopenia (FNAIT).

Abstract: The present invention relates to compositions and methods useful for analyzing lariat RNA, which plays a role in the regulation of gene expression. A sample of RNA is specifically treated to remove linear mRNA and enrich for lariat RNA. The enriched lariat RNA sample may be analyzed further to identify introns, branch point sequences, alternative splicing patters, and gene transcription levels. The enriched lariat RNA sample may also be exploited as a detection or compound screening tool, as well as other uses.

Abstract: Secure digital remediation methods and systems are provided for managing a reputation. A method for managing a reputation includes receiving a complaint from a victim regarding an unfavorable item published by one or more third parties, extracting information from the unfavorable item, and providing a communication to the one or more third parties of the complaint including the information, the communication requesting a response from the one or more third parties. The method also includes scoring the unfavorable item on a severity scale based on the information, responses to queries and/or a ruleset to produce a severity score, the ruleset including instructions for responding to the complaint based on the severity score.

Abstract: Secure digital remediation methods and systems are provided for managing a reputation. A method for managing a reputation includes receiving a complaint from a victim regarding an unfavorable item published by one or more third parties, extracting information from the unfavorable item, and providing a communication to the one or more third parties of the complaint including the information, the communication requesting a response from the one or more third parties. The method also includes scoring the unfavorable item on a severity scale based on the information, responses to queries and/or a ruleset to produce a severity score, the ruleset including instructions for responding to the complaint based on the severity score.

Abstract: In a constant velocity joint comprising an outer housing ring having an end wall with a journal and an inner surface provided with axially extending ball races and an inner ring member with outer ball races arranged in the outer housing ring and balls disposed in the ball races for the transmission of torque between the outer housing ring and the inner ring member, and a ball cage for retaining the balls in position in the ball races, a support ring is arranged in the housing ring between the end wall of the housing ring and the inner ring member for axially supporting the inner ring member during insertion of a shaft end into the inner ring member of the constant velocity joint.

Abstract: Disclosed are compositions comprising collagen covalently bound to particles, wherein covalent bonds are formed between reactive groups of the collagen and reactive groups of the particles, and wherein the particles have an average particle diameter ranging from 20 to 1000 nanometers. Also disclosed are various methods that utilize the compositions.

Abstract: A medical vacuum aspiration device includes an aspiration cylinder and a valve. The valve includes a removable fluid conduit, a valve housing having at least first and second housing portions, means for removably attaching the first housing portion to the second housing portion, and an actuator. The removable fluid conduit has a first end for attaching to a cannula and a second end for attaching to the aspiration cylinder. The first and second housing portions may define a cavity for removably holding at least a portion of the fluid conduit. The actuator is coupled to the valve housing and selectively compresses a portion of the fluid conduit to open and close a fluid path defined by the fluid conduit.

Abstract: The invention relates to a connecting mechanism for composite and plastic pipes with a metal layer and at least one plastic layer, a connecting portion, a supporting sleeve which adjoins the connecting portion in the direction opposite the fitting direction and a clamping ring with a radial, plastically deformable extension, the plastic deformation of which reduces its circumference.

Abstract: Sunscreens are colored with oil-soluble dyes approved for use in skin care products (such as sunscreens, lotions, etc.). The color imparted by the dyes substantially disappears shortly after the sunscreen emulsion is applied to skin. This colored sunscreen emulsion includes a oil-soluble phase, at least one sunscreen active agent, water, and an emulsifier. The oil-soluble phase comprises from about 0.0005 to about 0.5 percent by weight of the complete emulsion of at least one oil-soluble dye. The dye imparts a color other than white to the sunscreen emulsion.The sunscreen active ingredient is provided in an amount effective to protect against the actinic radiation of the sun. Sufficient water is provided to form the colored emulsion. The emulsion additionally contains at least one emulsifier in an amount effective to provide an at least substantially stable emulsion. Other optional ingredients may also be compounded into the sunscreen formulations.

Abstract: This invention relates to novel compositions containing temporary visual indicators and methods for using these compositions. Specifically, this invention relates to a sunscreen composition containing an indicator that is visible when the substance is applied to the skin, but becomes invisible shortly after application. The continued presence of the indicator allows the indicator to be reactivated temporarily to the visible form so that a user can verify the presence of the sunscreen. The visible indicator ensures that the sunscreen is applied evenly and completely to the area to be protected, but becomes invisible so as not to interfere with the action of the sunscreen or discolor the skin.

Abstract: A lotion such as a sunscreen includes a color indicator which brightly colorizes the lotion until the lotion is applied to human skin, wherein after the colored lotion changes color or turns clear. A physiological color indicator such as a pH indicator, a colorant or color indicator can be used, alone or in combination, to colorize the lotion in accord with the invention. The lotion is suitable for use in lotion, gel, mousse or medication that is best applied in an even and uniform manner to the skin. Accordingly, one preferred use of the invention is in UV-protection sunscreens so that a user can ensure even distribution of the sunscreen on the body. A sunscreen of the invention can also include an emollient, such as jojoba oil, an emulsifier, a surfactant, such as sorbitol, water, and a pH adjuster, such as triethanolaminie.

Abstract: Described is a process for producing heat-insulated panels for the large-scale panel method of construction, which can be used for the production of load-bearing and non-load-bearing walls and supporting walls. The process is characterised in that firstly a hard foam panel (5) is put on to or extruded on to at least one flat table (1), thereafter place-reserving devices in the form of frames or the like for for production of door, window and other openings (8, 14, 16, 18) and inner hollow chambers are put in accurately positioned relationship on to the hard foam panel, then the remaining free surfaces of the hard foam panel (5) are provided with connecting members (12) and preferably fixed by bonding agent and/or preferably undercut grooves are provided in the region of the free surfaces. A concrete layer (11) is then cast and compacted on to the hard foam panel (5) which is provided with an outer boundary means.

Abstract: Sunscreens are colored with oil-soluble dyes approved for use in skin care products (such as sunscreens, lotions, etc.). The color imparted by the dyes substantially disappears shortly after the sunscreen emulsion is applied to skin. This colored sunscreen emulsion includes a oil-soluble phase, at least one sunscreen active agent, water, and an emulsifier. The oil-soluble phase comprises from about 0.0005 to about 0.5 percent by weight of the complete emulsion of at least one oil-soluble dye. The dye imparts a color other than white to the sunscreen emulsion.The sunscreen active ingredient is provided in an amount effective to protect against the actinic radiation of the sun. Sufficient water is provided to form the colored emulsion. The emulsion additionally contains at least one emulsifier in an amount effective to provide an at least substantially stable emulsion. Other optional ingredients may also be compounded into the sunscreen formulations.

Abstract: This invention relates to novel compositions containing temporary visual indicators and methods for using these compositions. Specifically, this invention relates to a sunscreen composition containing an indicator that is visible when the substance is applied to the skin, but becomes invisible shortly after application. The continued presence of the indicator allows the indicator to be reactivated temporarily to the visible form so that a user can verify the presence of the sunscreen. The visible indicator ensures that the sunscreen is applied evenly and completely to the area to be protected, but becomes invisible so as not to interfere with the action of the sunscreen or discolor the skin.

Abstract: A lotion such as a sunscreen includes a color indicator which colorizes the lotion until the lotion is applied to human skin, whereinafter the colored lotion changes color or turns clear. A physiological color indicator such as a pH indicator, a colorant, or a water-soluble dye such as coumarin can be used, alone or in combination, to colorize the lotion in accord with the invention. The lotion is suitable for use in any lotion, gel, mousse or medication that is best applied in an even and uniform manner to the skin. Accordingly, one preferred use of the invention is in UV-protection sunscreens so that a user can ensure even distribution of the sunscreen on the body. A sunscreen of the invention can also include an emollient, such as jacoba oil, an emulsifier, a surfactant, such as sorbitol, water, and a pH adjuster, such as triethanolamine.

Abstract: A device is disclosed which fastens and retains a bonding and sealing device in a drilled hole in construction parts or in buildings by forcing injection material, such as snythetic resins into cracks and flaws present on the construction parts or on the building component. A sealing bushing encases a portion of a sleeve. The sleeve is expanded from its inside thereby sealingly clamping the sealing bushing between the walls of the drilled hole and the encased portion of the sleeve.

Abstract: A voltage detector has a plurality of voltage detection circuits which, at their respective inputs, are electrically connected in common to a feeler serving as a test probe for contacting a power line conductor. The detection circuits are cascaded in the order of successively increasing individual voltage detection thresholds thereof at and above which they respectively produce output signals in response to the feeler voltage, the arrangement being such that each circuit other than the circuit of lowest threshold is enabled to produce its output signal only upon an output signal being produced by the circuit immediately preceding it. The circuit outputs are connected to respective inputs of a warning signal generator which produces an output warning signal uniquely characteristic of the number of detection circuit output signals it receives and thus uniquely characteristic of the voltage condition of the power line conductor contacted by the probe.