Abstract: The present invention pertains to an analytics engine, system and method for providing risk/opportunity assessment and decision support solutions to users, such as for life sciences and healthcare constituents. The system includes an ontology based risk analytics engine that enhances its clients' decision making by systematically identifying and quantifying knowledge, which presents unexplored opportunities or risks. This independent review and evaluation leads to action plans that optimize critical project planning, improve success and outcome and lower costs. The system complements and extends existing internal decision processes and facilitates the systematic and unbiased application of knowledge to assist in making the best-informed decisions.