Patents Assigned to IPROGEN BIOTECH, INC.
  • Intracellular protein delivery
    Patent number: 9994829
    Abstract: A secretion signal peptide sequence (SP) in combination with a cleavage inhibition sequence (CIS) fused to a structural gene sequence in a recombinant expression system can be used to express a full length protein with an SP in a cell. Such a fusion protein may be purified to homogeneity from a membrane fraction of the cell. The SP in combination with the CIS is a protein transduction domain that exhibits superior intracellular protein transduction efficiency when the SP precedes the CIS in a N to C-terminus direction.
    Type: Grant
    Filed: July 2, 2013
    Date of Patent: June 12, 2018
    Assignee: IPROGEN BIOTECH, INC.
    Inventors: Keun Ho Lee, Leo Yen-Cheng Lin, Aikun Wang