Patents Assigned to Ipsen Manufacturing Ireland Limited
  • Process for the synthesis of therapeutic peptides
    Patent number: 9475837
    Abstract: The present invention relates to a process for the large-scale synthesis of therapeutic peptides using a Sieber Amide resin, which comprises solid-phase Fmoc-chemistry.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: October 25, 2016
    Assignee: IPSEN MANUFACTURING IRELAND LIMITED
    Inventors: Fionn Hurley, Katarzyna Wegner, Patrick Foley
  • Boc and Fmoc solid phase peptide synthesis
    Patent number: 9090654
    Abstract: A solid phase method for synthesizing a peptide containing three or more amino acid residues utilizing both Boc and Fmoc protected amino acids and a chloromethylated polystyrene resin.
    Type: Grant
    Filed: January 4, 2013
    Date of Patent: July 28, 2015
    Assignee: IPSEN MANUFACTURING IRELAND LIMITED
    Inventors: Catherine Fiona Dalton, John Stuart Eynon, Steven Allen Jackson, Gary Alexander Siwruk
  • BOC AND FMOC SOLID PHASE PEPTIDE SYNTHESIS
    Publication number: 20130338337
    Abstract: A solid phase method for synthesizing a peptide containing three or more amino acid residues utilizing both Boc and Fmoc protected amino acids and a chloromethylated polystyrene resin.
    Type: Application
    Filed: January 4, 2013
    Publication date: December 19, 2013
    Applicant: IPSEN MANUFACTURING IRELAND LIMITED
    Inventor: Ipsen Manufacturing Ireland Limited
  • Transdermal Administration Of Peptides
    Publication number: 20130085105
    Abstract: The present invention relates to a method of increasing the bioavailability of a peptide. The method includes altering the lipophilicity of a peptide by the creation of fatty acid peptide salts of the peptide. The fatty acid peptide salts exhibit increased transdermal and transmucosal permeability.
    Type: Application
    Filed: March 23, 2011
    Publication date: April 4, 2013
    Applicants: The Provost, Fellows and Scholars of the College of Holy Trinity and Undivided Trinity of Queen Eli, Ipsen Manufacturing Ireland Limited
    Inventors: Patrick Bernard Deasy, Thomas Ciaran Loughman
  • Boc and Fmoc solid phase peptide synthesis
    Patent number: 8383770
    Abstract: A solid phase method for synthesizing a peptide containing three or more amino acid residues utilizing both Boc and Fmoc protected amino acids and a chloromethylated polystyrene resin.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: February 26, 2013
    Assignee: IPSEN Manufacturing Ireland Limited
    Inventors: Catherine Fiona Dalton, John Stuart Eynon, Steven Allen Jackson, Gary Alexander Siwruk
  • BOC AND FMOC SOLID PHASE PEPTIDE SYNTHESIS
    Publication number: 20100160604
    Abstract: A solid phase method for synthesizing a peptide containing three or more amino acid residues utilizing both Boc and Fmoc protected amino acids and a chloromethylated polystyrene resin.
    Type: Application
    Filed: August 31, 2007
    Publication date: June 24, 2010
    Applicant: Ipsen Manufacturing Ireland Limited
    Inventors: Catherine Fiona Dalton, John Stuart Eynon, Steve Allen Jackson, Gary Alexander Siwruk
  • Sustained release ionic conjugate
    Patent number: 7179490
    Abstract: A method of spherifying a sustained release ionic conjugate which contains a free carboxyl group-containing biodegradable polymer and a free amino group-containing drug which are ionically bonded to each other.
    Type: Grant
    Filed: January 19, 2006
    Date of Patent: February 20, 2007
    Assignee: Ipsen Manufacturing Ireland Limited
    Inventors: Francis Xavier Ignatious, Thomas Ciaran Loughman, Shalaby Wahba Shalaby, Franck Jean-Claude Touraud
  • Process for the synthesis of a peptide having a Trp residue
    Patent number: 7122628
    Abstract: A process for the solid phase synthesis of a peptide having at least one thyptophan residue, wherein said method comprises temporarily protecting the indole ring of said tryptophan residue with a side chain protecting group which is labile to a base wherein said protecting group is removed during cleavage of said peptide from the solid support.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: October 17, 2006
    Assignee: Ipsen Manufacturing Ireland, Limited
    Inventor: Steven Allen Jackson
  • Sustained release ionic conjugate
    Patent number: 7026431
    Abstract: A method of spherifying a sustained release ionic conjugate which contains a free carboxyl group-containing biodegradable polymer and a free amino group-containing drug which are ionically bonded to each other.
    Type: Grant
    Filed: August 7, 2003
    Date of Patent: April 11, 2006
    Assignee: Ipsen Manufacturing Ireland Limited
    Inventors: Francis Xavier Ignatious, Thomas Ciaran Loughman, Shalaby Wahba Shalaby, Franck Jean-Claude Touraud
  • Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides
    Patent number: 7005420
    Abstract: A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypeptide present in said composition is ionically bound to said polymer.
    Type: Grant
    Filed: July 27, 2004
    Date of Patent: February 28, 2006
    Assignee: Ipsen Manufacturing Ireland Limited
    Inventors: Shalaby W. Shalaby, Ruth M. Russell, Jacques-Pierre Moreau, Steven A. Jackson, Francis X. Ignatious
  • Sustained release ionic conjugate
    Patent number: 6911218
    Abstract: A method of spherifying a sustained release ionic conjugate which contains a free carboxyl group-containing biodegradable polymer and a free amino group-containing drug which are ionically bonded to each other.
    Type: Grant
    Filed: April 22, 1997
    Date of Patent: June 28, 2005
    Assignee: Ipsen Manufacturing Ireland Limited
    Inventors: Francis Xavier Ignatious, Thomas Ciaran Loughman, Shalaby Wahba Shalaby, Franck Jean-Claude Touraud
  • Process to make a sustained release formulation
    Patent number: 6893645
    Abstract: This invention pertains to a process for making a sustained release complex. Compound (I), which comprises Compound (A), having formula (A), and a copolymer comprising poly (l)-lactic-glycolic-tartaric acid (P(I)LGT), wherein the amino group of Compound (A) is ionically bound to a carboxyl group of the (P(I)LGT).
    Type: Grant
    Filed: August 14, 2000
    Date of Patent: May 17, 2005
    Assignee: Ipsen Manufacturing Ireland Limited
    Inventor: Thomas Ciarán Loughman