Abstract: The invention provides a protein comprising hepatitis B core antigen (HBcAg) with a sugar attached to an e1 loop. The protein may comprise a first and a second copy of HBcAg in tandem, wherein one or both copies of HBcAg has a sugar attached to the e1 loop. The first copy may have a sugar attached to the e1 loop and the second copy may comprise a peptide epitope in the e1 loop. The protein may be used to induce an immune response against the sugar and hence act as a vaccine.
Type:
Grant
Filed:
February 18, 2015
Date of Patent:
April 24, 2018
Assignee:
IQUR LIMITED
Inventors:
Michael Anthony Whelan, Robert A. Field, David J. Rowlands
Abstract: The invention provides a protein comprising a first and a second copy of hepatitis B core antigen (HBcAg) in tandem, in which one or both of the copies of HBcAg comprises influenza virus A surface polypeptide M2 or a fragment thereof in the e1 loop.
Type:
Application
Filed:
October 22, 2010
Publication date:
July 4, 2013
Applicant:
iQUR Limited
Inventors:
Michael Anthony Whelan, William Malcolm Rosenberg, Lucy Phillipa Beales
Abstract: The present invention relates to methods for differentiating Hepatitis C virus (HCV) group A genotypes from HCV group B genotypes. The invention finds application in determining prognosis, and in the selection of treatment regimes, for patients infected with HCV.
Type:
Application
Filed:
October 21, 2005
Publication date:
May 21, 2009
Applicant:
IQUR LIMITED
Inventors:
Richard Cross, William Malcolm Charles Rosenberg