Patents Assigned to IRBM S.P.A.
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Publication number: 20240148745Abstract: The present invention provides compounds able to induce neuroprotection of damaged neurons and boost the remyelination potential of oligodendrocytes. The compounds have been identified through methods of pharmacological screening of a small molecule library consisting of known pharmacologically active compounds and approved drugs. The screening method is also included in the invention.Type: ApplicationFiled: March 9, 2022Publication date: May 9, 2024Applicants: FONDAZIONE CENTRO SAN RAFFAELE, INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE, ASSISTANCE PUBLIQUE HOPITAUX DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, SORBONNE UNIVERSITE, WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTER, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, HEINRICH HEINE UNIVERSITY DÜSSELDORF, UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ, THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY, ISTITUTO SUPERIORE DI SANITÀ, CONSIGLIO NAZIONALE DELLE RICERCHE, IRBM S.P.A.Inventors: Gianvito MARTINO, Paola PANINA, Brahim NAIT-OUMESMAR, Anne BARON-VAN EVERCOOREN, Tanja KUHLMANN, Sergio BARANZINI, Norbert GOEBELS, Frauke ZIPP, Nicholas HANUSCHECK, Jack ANTEL, Cristina AGRESTI, Maria Pia ABBRACCHIO, Ivano EBERINI, Chiara PARRAVICINI, Stefania OLLA, Alberto BRESCIANI
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Publication number: 20220289753Abstract: The present invention relates to new compounds capable of inhibiting the activity of SHP2 phosphatase, having the general Formula (I).Type: ApplicationFiled: August 7, 2020Publication date: September 15, 2022Applicants: IRBM S.P.A., C.N.C.C.S. S.C.A.R.L. COLLEZIONE NAZIONALE DEI COMPOSTI CHIMICI E CENTRO SCREENINGInventors: Alina CIAMMAICHELLA, Federica FERRIGNO, Jesus Maria ONTORIA ONTORIA, Alessia PETROCCHI, Simona PONZI, Ilaria ROSSETTI, Alessio SFERRAZZA, Esther TORRENTE
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Publication number: 20220241241Abstract: The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing the compounds.Type: ApplicationFiled: May 25, 2020Publication date: August 4, 2022Applicants: ISTITUTO NAZIONALE DI GENETICA MOLECOLARE - INGM, OSPEDALE SAN RAFFAELE S.R.L., IRBM S.P.A.Inventors: Raffaele DE FRANCESCO, Lorena DONNICI, Luca GUIDOTTI, Matteo IANNACONE, Romano DI FABIO, Vincenzo SUMMA, Adolfo PRANDI, Pietro RANDAZZO, Leda IVANOVA BENCHEVA, Marilenia DE MATTEO, Luca FERRANTE, Davide GORNATI, Alessandro GRILLO
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Publication number: 20220110943Abstract: The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing the compounds.Type: ApplicationFiled: August 9, 2019Publication date: April 14, 2022Applicants: OSPEDALE SAN RAFFAELE S.R.L., IRBM S.P.A., PROMIDIS S.R.L., ISTITUTO NAZIONALE DI GENETICA MOLECOLARE - INGMInventors: Raffaele DE FRANCESCO, Lorena DONNICI, Luca GUIDOTTI, Matteo IANNACONE, Romano DI FABIO, Vincenzo SUMMA, Adolfo PRANDI, Pietro RANDAZZO, Davide GORNATI, Alessandro GRILLO, Luca FERRANTE, Leda Ivanova BENCHEVA, Marilenia DE MATTEO, Marco FERRARA
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Publication number: 20210276967Abstract: The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing said compounds.Type: ApplicationFiled: July 19, 2019Publication date: September 9, 2021Applicants: OSPEDALE SAN RAFFAELE S.R.L., IRBM S.P.A., PROMIDIS S.R.L., ISTITUTO NAZIONALE DI GENETICA MOLECOLARE - INGMInventors: Raffaele DE FRANCESCO, Adolfo PRANDI, Pietro RANDAZZO, Lorena DONNICI, Luca GUIDOTTI, Matteo IANNACONE, Romano DI FABIO, Vincenzo SUMMA, Leda Ivanova BENCHEVA, Marilenia DE MATTEO, Luca FERRANTE