Abstract: The present invention relates to a pharmaceutical composition containing a local anesthetic or a centrally acting analgesic, comprising a lipophilic portion, the anesthetic or analgesic being encapsulated in liposomes.

Abstract: The invention relates to new quinoline derivatives containing a free amine group and having antimalarial properties, in particular new primaquine derivatives or their addition salts with acids, and to a method for preparing them.According to the invention, these new derivatives are represented schematically by the formula:PQ-Xin which PQ denotes quinolines containing a free amine group and having antimalarial properties, in particular primaquine; X denotes an amino acid or a peptide of 2 to 4 amino acids; and the PQ-X bond being a covalent peptide bond between the free amine group of PQ and the carboxyl group of X, the PQ-X covalent bond being stable in serum and resistant to lysosomal hydrolases.In an embodiment of the invention, the amino acid or the first amino acid of a peptide linked to PQ is gamma-L-glutamic acid or beta-aspartic acid linked to PQ via their beta- or gamma-carboxyl group, or L-pyroglutamic acid or aspartic acid linked to PQ via their alpha-carboxyl group.

Abstract: Compound useful particularly for the treatment by targetted radiotherapy or imaging of cancer, characterized in that the compound is comprised of a molecule susceptible of fixing itself or passing close to the DNA of the target cells, said molecule being radiolabelled with iodine 123. The invention also relates to new ligands specific of steroid hormone receivers useful for the targetted therapy or imaging particularly of cancer and presenting a structural base skeleton having the formula (I). According to the invention these ligands comprise particularly a) a hydroxyl or ketone function in position C.sub.3 ; b) a .beta. chloromethyl function on position C.sub.11 ; c) an .alpha. methyl or vinyl function on position C.sub.17 and d) a substituted radioactive iodine on an alkyl or alkenyl group attached to the skeleton, particularly methyl or vinyl.

Abstract: The subject of the present invention is conjugates of vinca (indole-dihydroindole) derivatives carrying a detergent chain of at least 7 aliphatic carbon atoms in the C-3 position bonded via a covalent bond to a macromolecular carrier of polypeptide character, and also pharmaceutical compositions containing these conjugates and a process of preparation.

Abstract: The present invention relates to specific ligands for estrogen or progestagen steroid hormone receptors which have the formula ##STR1## in which X denotes a vinyl group substituted by a radioactive or nonradioactive halogen on the double bond according to a Z isomerism, andY denotes either a hydroxyl group, in which case the ring to which it is attached is an aromatic ring, or a ketone functional group, in which case it is conjugated with a double bond at C.sub.4 -C.sub.5.An application of the ligands according to the invention is the targeted therapy and/or medical imagery, especially of cancer. However, these ligands can also be employed in the quantitative determination of said hormone receptors.However, the labeled ligands according to the invention are of very particular interest in the case of the targeted radiotherapy of cancer.

Abstract: The present invention relates to probes of nucleic acids useful for detecting indifferently the various types of human papilloma virus, particularly HPV1a, HPV5, HPV6b, HPV8, HPV11, HPV16, HPV18 and HPV33, especially a probe comprising a labelled sequence of nucleic acids, characterized in that it comprises the oligomer of twelve nucleotides X-A-A-A-A-C-G-A-A-A-G-X, with X=T or U, or its complement by interchanging A and X on the one hand, C and G on the other hand. The present invention also relates to specific probes of nucleic acids for the detection of human papilloma for each of the types HPV1a, HPV5, HPV8, HPV11, HPV16, HPV18 and HPV33, as well as specific probes of sub-groups of the virus HPV16, HPV18, HPV33 or HPV16 and HPV18 only or again HPV5 and HPV8 only.

Abstract: The present invention relates to microcrystals of a substance, which substance is insoluble in water and has an affinity for phospholipids, as well as a process for its preparation. According to the invention, one or more organic solvents are evaporated from a solution of phospholipids and substance, and the film obtained thereby, after evaporation of the one or more solvents, is suspended in an aqueous solution by vigorous stirring. The invention also relates to pharmaceutical compositions containing as active principle these microcrystals, particularly liquid pharmaceutical compositions packaged in injectable form or in sprayable form.

Abstract: The present invention relates to microparticles containing an active principle against malaria, such as primaquine, one of its amino acid derivatives, or their conjugates with a hepatotropic vector or their pharmaceutically acceptable salts, and a biocompatible and biodegradable polymer controlling the kinetics of release of the active principle, like (DL)polylactide. The invention also relates to pharmaceutical compositions comprising microcapsules according to the invention. Lastly, the invention relates to processes for the preparation of microparticles as mentioned above, the processes comprising: dissolving the polymer in a volatile solvent, adding to this solution the active principle and possibly a substance regulating the size of the microparticles, and at the end of evaporation, recovering the microparticles by centrifugation and filtration.

Abstract: The invention relates to vinca (indole-dihydroindole) alkaloid derivatives, in which a fatty chain containing at least 7 aliphatic carbon atoms is present at least at the C.sup.3 /C.sup.4 -position.The derivatives according to the present invention are useful as drugs.

Abstract: The present invention relates to compounds of formula ##STR1## in which Q is N or CH,Ar is a radical chosen from among phenyl and optionally substituted thienyl radicals, it being possible for the substituents to be from one to three substituents: halo, lower alkyl or lower alkoxy,--AA-- represents a divalent radical corresponding to an amino acid forming part of the structure of proteins, it being possible for some functional groups of this radical to be protected, or alternatively, it represents a diacyl radical,n is an integer from 0 to 4 inclusive, andX represents H, OH or Y, ##STR2## in which when n is equal to 1, 2, 3 or 4, Y is then a hydrocarbon radical containing from 1 to 20 carbon atoms,when n is equal to 0, Y is then a hydrocarbon radical containing from 7 to 20 carbon atoms, as well as to the salts and the isomers of these compounds, to a process for the preparation of these compounds, to their application as fungicidal and/or bactericidal agents and to their compositions containing them.