Abstract: Systems and methods for high voltage conversion and multiplication for ionizing radiation detection are disclosed. According to an aspect, an electronic device comprises at least one detector configured for detecting ionizing radiation. Further, the electronic device comprises a translator assembly coupled to the at least one detector and configured to convert a voltage from a first voltage level to a second voltage level, wherein the at least one detector operates at the first voltage level. Further, the translator assembly is configured to voltage isolate the at least one detector operating at the first voltage level from a coupled electronic circuit operating at the second voltage level.