Abstract: A method of delivering a solution including at least one drug is provided. The method includes providing a fluid exchange catheter system which includes an inner lumen, the proximal end of which is connected to an infusion mechanism configured to control infusion of a solution that includes at least one drug, and an outer lumen, the proximal end of which is connected to an aspiration mechanism configured to control aspiration of fluid from the body. The method also includes activating the infusion mechanism to infuse the solution into the body for a first infusion time period and at a first infusion pressure, disabling the infusion mechanism to stop infusion, and activating the aspiration mechanism to aspirate fluid for a first aspiration time period and at a first aspiration pressure. Also described is a method of unblocking a fluid exchange catheter.

Abstract: A method of infusing and aspirating fluid from the body is provided. The method includes providing a catheter system which includes an inner lumen, the proximal end of which is connected to an infusion mechanism configured to control infusion of a fluid, and an outer lumen, the proximal end of which is connected to an aspiration mechanism configured to control aspiration of fluid from the body. The method also includes activating the infusion mechanism to infuse fluid into the body for a first infusion time period and at a first infusion pressure, disabling the infusion mechanism to stop infusion, and activating the aspiration mechanism to aspirate fluid for a first aspiration time period and at a first aspiration pressure.

Abstract: A method of infusing and aspirating fluid from the body is provided. The method includes providing a catheter system which includes an inner lumen, the proximal end of which is connected to an infusion mechanism configured to control infusion of a fluid, and an outer lumen, the proximal end of which is connected to an aspiration mechanism configured to control aspiration of fluid from the body. The method also includes activating the infusion mechanism to infuse fluid into the body for a first infusion time period and at a first infusion pressure, disabling the infusion mechanism to stop infusion, and activating the aspiration mechanism to aspirate fluid for a first aspiration time period and at a first aspiration pressure.

Abstract: According to the invention, a fluid exchange catheter is provided, which catheter has a proximal end and a distal end, and comprises an obligatory lumen having a proximal end and a distal end, the distal end of the obligatory lumen having a closed shape, wherein a lumen wall of the obligatory lumen forms a distal wall portion at the distal end of the obligatory lumen, the distal wall portion comprising at least one lumen opening in the lumen wall. Furthermore, the catheter comprises at least one additional lumen having a proximal end and a distal end, the distal end being arranged inside the obligatory lumen remote from the distal end of the obligatory lumen such that fluid exiting the at least one additional lumen flows inside the distal end of the obligatory lumen.

Abstract: A method of infusing and aspirating fluid from the body is provided. The method includes providing a catheter system which includes an inner lumen, the proximal end of which is connected to an infusion mechanism configured to control infusion of a fluid, and an outer lumen, the proximal end of which is connected to an aspiration mechanism configured to control aspiration of fluid from the body. The method also includes activating the infusion mechanism to infuse fluid into the body for a first infusion time period and at a first infusion pressure, disabling the infusion mechanism to stop infusion, and activating the aspiration mechanism to aspirate fluid for a first aspiration time period and at a first aspiration pressure.

Abstract: A catheter system that can be used for concurrent fluid infusion and aspiration in humans, animals and biological material, at a wide range of flow rates, without any blockage problems. The system has devices that control the infused liquid's pressure changes accordingly to the aspirated liquid's pressure changes, in order to allow accurate and safe fluid exchange flow control and create changes of pressures at the catheter's tip that do not allow the catheter's blockage.