Patents Assigned to Irvine Scientific Sales Company
  • Publication number: 20190106668
    Abstract: A method of reconstituting a powdered cell culture media includes providing a mixing apparatus and providing a powdered cell culture media to the fluid chamber of the mixing apparatus, prior to introducing fluid to the chamber. The method further includes introducing fluid to the chamber through an influent port, wherein the influent port is tangentially oriented relative to an inner wall of the fluid chamber to thereby cause the fluid to follow the wall of the fluid chamber in a circular motion, creating a vortex flow in the fluid chamber by introducing fluid at a sufficient flow rate, and enhancing the vortex flow with a geometric fluid flow aid by further channeling the water around the wall of the fluid chamber, around the geometric flow aid. The method further includes continuing to introduce fluid to the chamber and collecting reconstituted fluid that exits the chamber through the effluent port.
    Type: Application
    Filed: December 7, 2018
    Publication date: April 11, 2019
    Applicant: IRVINE SCIENTIFIC SALES COMPANY, INC.
    Inventor: Thomas Reid FLETCHER
  • Publication number: 20190001290
    Abstract: An automated method includes providing a dry ingredient to be reconstituted into a liquid bioprocess solution and controlling, by a processing circuit, all automated system including at least one mixing chamber, an array of tubing for fluid flow within the system, and a plurality of valves provided within the tubing, to automatically prepare the liquid bioprocess solution from the dry ingredient. Controlling the auto system may include performing a series of sequential mixing steps, the series of sequential mixing steps causing the preparation of the liquid bioprocess solution. The method mixing include taking one or more measurements during the preparation of the liquid bioprocess solution, wherein each step is triggered by at least one of a measurement decreasing below, equaling, or exceeding a measurement threshold. Each step may also include opening or closing, by the processing circuit, at least one of the plurality of valves.
    Type: Application
    Filed: June 25, 2018
    Publication date: January 3, 2019
    Applicant: Irvine Scientific Sales Company, Inc.
    Inventor: Thomas Reid Fletcher
  • Patent number: 10150941
    Abstract: A mixing apparatus for reconstituting a powdered cell culture media. The apparatus includes at least one fluid chamber, an influent port at a lower portion of the fluid chamber. The apparatus further includes a geometric fluid flow aid positioned in the fluid chamber and an effluent port at the top of the fluid chamber. A powdered cell culture media is provided in the fluid to be mixed with a fluid provided by the influent port. The effluent port is configured to allow reconstituted media to exit the fluid chamber.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: December 11, 2018
    Assignee: Irvine Scientific Sales Company, Inc.
    Inventor: Thomas Reid Fletcher
  • Publication number: 20180311337
    Abstract: Disclosed is an adapted Madin-Darby canine kidney cell line capable of suspension culture in the absence of serum, and a chemically-defined medium for culture of the adapted MDCK cell line. Further disclosed are culture methods for growing the adapted MDCK cell line and methods for producing a vaccine from the adapted MDCK cell line grown in the chemically-defined medium.
    Type: Application
    Filed: October 31, 2016
    Publication date: November 1, 2018
    Applicants: NATIONAL INSTITUTE OF INFECTIOUS DISEASES AND VACCINOLOGY, NATIONAL HEALTH RESEARCH INSTITUTES, IRVINE SCIENTIFIC SALES COMPANY, INC.
    Inventors: Jenny BANG, Hsiao-Tzu NI, Alan Yung-Chih HU, Tsai-Chuan WENG
  • Publication number: 20170145368
    Abstract: A mixing apparatus for reconstituting a powdered cell culture media. The apparatus includes at least one fluid chamber, an influent port at a lower portion of the fluid chamber. The apparatus further includes a geometric fluid flow aid positioned in the fluid chamber and an effluent port at the top of the fluid chamber. A powdered cell culture media is provided in the fluid to be mixed with a fluid provided by the influent port. The effluent port is configured to allow reconstituted media to exit the fluid chamber.
    Type: Application
    Filed: March 31, 2016
    Publication date: May 25, 2017
    Applicant: Irvine Scientific Sales Company, Inc.
    Inventor: Thomas Reid Fletcher
  • Publication number: 20150018605
    Abstract: Improved methods of culturing embryos in media having amounts of lactate that have not previously been recognized as beneficial for embryo development. Also, compositions, devices and kits related to the same.
    Type: Application
    Filed: July 9, 2014
    Publication date: January 15, 2015
    Applicant: Irvine Scientific Sales Company, Inc.
    Inventors: Rebecca Gilbert, Hsiao-Tzu Ni, Suh-Fon Hwan
  • Patent number: 6406909
    Abstract: The present invention relates to a serum-free medium for culturing animal cells which contains soybean protein hydrolysate and yeast extract; a method for culturing animal cells which comprises a step of culturing animal cells in the serum-free medium; and a method for producing a desired substance which comprises a step of culturing animal cells in the serum-free medium, causing the desired substance to be produced by and secreted out of the animal cells and a step of isolating the desired substance from the serum-free medium.
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: June 18, 2002
    Assignees: Chugai Seiyaku Kabushiki Kaisha, Irvine Scientific Sales Company
    Inventors: Kazushi Shibuya, Masaru Atsumi, Shigeyuki Tsunakawa, Kaneo Nogaki, Thomas Reid Fletcher, Katsuyuki Imada, Bjorn Kenneth Lydersen