Abstract: The present invention concerns pharmaceutical compositions formulated for topical application that are useful in the treatment of HPV-related pathologies and in particular the treatment of premalignant and malignant conditions of the cervix. The compositions comprise a therapeutically effective amount of lopinavir and ritonavir in a pharmaceutically acceptable vehicle and wherein the weight ratio (w/w) of lopinavir:ritonavir is between 9:1 and 18:1.
Abstract: The present invention relates to a pharmaceutical formulation comprising the drug 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one in a solid dispersion with a matrix polymer that exhibits low hygroscopicity and high softening temperature, such as copovidone. The invention also relates to a daily pharmaceutical dose of the drug provided by such a formulation. In addition, the invention relates to the use of a matrix polymer that exhibits low hygroscopicity and high softening temperature in solid dispersion with 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one for increasing the bioavailability of the drug.
Type:
Grant
Filed:
May 4, 2023
Date of Patent:
May 7, 2024
Assignee:
KUDOS PHARMACEUTICALS LIMITED
Inventors:
Michael Karl Bechtold, Julie Kay Cahill, Katja Maren Fastnacht, Kieran James Lennon, Bernd Harald Liepold, Claudia Bettina Packhaeuser, Benedikt Steitz
Abstract: This invention relates to compounds that are agonists of the muscarinic M1 and/or M4 receptor and which are useful in the treatment of diseases mediated by the muscarinic M1 and M4 receptors. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds provided are of formula where X1; X2; R1 and R4 are as defined herein.
Type:
Grant
Filed:
December 9, 2019
Date of Patent:
April 2, 2024
Assignees:
Heptares Therapeutics Limited, Allergan Pharmaceuticals International Limited
Inventors:
Giles Albert Brown, Barry John Teobald, Benjamin Gerald Tehan
Abstract: This invention relates generally to therapeutic parenteral formulations comprising particular substituted pyridine based compounds, their manufacture, and methods and uses of said formulations in treating elevated intracranial pressure for indications such as, but not limited to, traumatic brain injury and stroke.
Type:
Application
Filed:
September 26, 2023
Publication date:
March 21, 2024
Applicant:
Eustralis Pharmaceuticals Limited (Trading as Pressura Neuro)
Inventors:
Pierre VANKAN, Andreea SASARMAN, Grasiela Bourscheit WILLMBRINK
Abstract: An intravenous composition for providing relief for pain and/or inflammation, the composition having ibuprofen and paracetamol in combination for delivering to a human at each dose: a) approximately 125 mg to approximately 175 mg ibuprofen in combination with approximately 475 mg to approximately 525 mg paracetamol; or b) approximately 275 mg to approximately 325 mg ibuprofen in combination with approximately 975 mg to approximately 1,025 mg paracetamol.
Abstract: Solid oral dosage forms containing 325 mg of acetaminophen and 97.5 mg of ibuprofen or 500 mg of acetaminophen and 150 mg of ibuprofen, wherein the ibuprofen has a [D50] between 1 and 9 ?m, are described.
Abstract: This disclosure describes compounds of Formula (I), stereoisomers, side compounds thereof, pharmaceutical compositions and methods of manufacturing such compounds, using silylation reagents and producing compositions and products made using such methods. More particularly, this disclosure describes manufacture of trofinetide and side products, compositions and products containing such compounds, for pharmaceutical uses to treat neurodegenerative or neurodevelopmental disorders.
Type:
Grant
Filed:
June 23, 2022
Date of Patent:
January 9, 2024
Assignee:
NEUREN PHARMACEUTICALS LIMITED
Inventors:
Clive Blower, Mathew Peterson, James Murray Shaw, James Anthony Bonnar, Etienne David Frank Philippe Moniotte, Martin Bernard Catherine Bousmanne, Cecilia Betti, Karel Willy Luc Decroos, Mimoun Ayoub
Abstract: The invention relates to pharmaceutical compositions containing both (+)-?-dihydrotetrabenazine and (?)-?-dihydrotetrabenazine and their therapeutic uses, for example in the treatment of movement disorders, such as Tourette's syndrome.
Abstract: The invention provides (+)-?-dihydrotetrabenazine succinate salt. Also provided are (+)-?-dihydrotetrabenazine succinate salt for use in medicine, pharmaceutical compositions comprising (+)-?-dihydrotetrabenazine succinate salt and a pharmaceutically acceptable excipient and the uses of (+)-?-dihydrotetrabenazine succinate salt as a VMAT2 receptor antagonist and in the treatment of a movement disorder such as Tourette's syndrome. The invention further provides a method for preparing the (+)-?-dihydrotetrabenazine succinate salt.
Abstract: Provided herein are pharmaceutical compositions comprising a therapeutically effective amount of a lipophilic compound and a pharmaceutically acceptable carrier adapted for peri-ocular transdermal delivery of the lipophilic compound to one or more periorbital glands and/or the ocular surface tissues of a subject. Further provided herein are methods of using such pharmaceutical compositions for providing relief of one or more signs or symptoms of an ocular disease, methods of using one or more Meibomian glands (and meibum therein) as a drug delivery system for a lipophilic compound (e.g., a steroid) to the ocular surface, and kits related thereto.
Abstract: A medicine bottle for separately containing, preparing, and delivering solid and liquid medicine includes a bottle body, a first sealing separator, a second sealing separator, a sliding penetration rod, and a protective structure. The first sealing separator and the second sealing separator are separately sealed and arranged inside the bottle body to separate a compartment of the bottle body into upper, middle, and lower chambers. The sliding penetration rod is arranged inside the upper chamber of the bottle body as a cylinder in clearance fit with an inner wall of the bottle body, forming piston-like connection allowing for relative sliding. The sliding penetration rod has a through hole inside and a length greater than a sum of lengths of the upper and lower chambers of the bottle body. The protective structure is cup-shaped and fastened upside-down on a top of the bottle body to protect the sliding penetration rod.
Abstract: This invention relates generally to therapeutic parenteral formulations comprising particular substituted pyridine based compounds, their manufacture, and methods and uses of said formulations in treating elevated intracranial pressure for indications such as, but not limited to, traumatic brain injury and stroke.
Type:
Grant
Filed:
February 1, 2019
Date of Patent:
October 31, 2023
Assignee:
Eustralis Pharmaceuticals Limited
Inventors:
Pierre Vankan, Andreea Sasarman, Grasiela Bourscheit Willmbrink
Abstract: This invention relates to a novel process for making dihydrotetrabenazines, and in particular (+)-?-dihydrotetrabenazine, novel synthetic intermediates for use in the process and processes for making the intermediates.
Abstract: Provided herein are pharmaceutical compositions comprising a therapeutically effective amount of a lipophilic compound and a pharmaceutically acceptable carrier adapted for pen-ocular transdermal delivery of the lipophilic compound to one or more periorbital glands and/or the ocular surface tissues of a subject. Further provided herein are methods of using such pharmaceutical compositions for providing relief of one or more signs or symptoms of an ocular disease, methods of using one or more Meibomian glands (and meibum therein) as a drug delivery system for a lipophilic compound (e.g., a steroid) to the ocular surface, and kits related thereto.
Abstract: Crystalline salts of compounds, methods of making the same, and methods of treatment of dyslipidemia including administration of the crystalline salts, are provided.
Type:
Application
Filed:
March 1, 2023
Publication date:
September 7, 2023
Applicant:
CVI Pharmaceuticals Limited
Inventors:
Shenyi Shi, Feng Wang, Jingwen Liu, Jian Yang
Abstract: The present invention relates to a modified collagen obtainable by providing isolated collagen; freezing the isolated collagen; dehydrating the frozen collagen; and maturing the dehydrated collagen. Also disclosed are methods of preparing the modified collagen and uses thereof.
Abstract: The disclosure is directed to, in part, compounds, or pharmaceutically acceptable salts or solvates thereof, for modulating the activity of aldehyde dehydrogenase such as ALDH2 and/or methods for treating and/or preventing an alcohol related disorder such as alcohol use disorder, alcohol induced disorder, alcohol abuse, alcohol dependence, alcohol intoxication, alcohol withdrawal, and the like and/or methods for reducing the amount of alcohol consumed, reducing alcoholic cravings, or increasing the percentage of no heavy drinking days for a subject with alcohol use disorder.
Type:
Grant
Filed:
January 10, 2023
Date of Patent:
September 5, 2023
Assignee:
SOPHROSYNE PHARMACEUTICALS LIMITED
Inventors:
Lewis Feldberg, Akram Sabouni, Vincent Wing-Fai Tai
Abstract: The present invention concerns pharmaceutical compositions formulated for topical application that are useful in the treatment of HPV-related pathologies and in particular the treatment of premalignant and malignant conditions of the cervix. The com-positions comprise a therapeutically effective amount of lopinavir and ritonavir in a pharmaceutically acceptable vehicle and wherein the weight ratio (w/w) of lopinavir: ritonavir is between 9:1 and 18:1.
Abstract: Aqueous formulations and kits of radiopharmaceutical compounds of general Formula (II) protected from radiolysis with stabilisers, such as L-methionine and gentisic acid, are disclosed, wherein the compounds are based on sarcophagine ligands coordinated to a radioisotope, such as 64-copper, and linked to a tetrazine group for reaction with tumour targeting antibodies having functional reactive groups such as trans-cyclooctene, processes of preparing said radioligand formulations, and uses thereof for radioimaging, diagnosing and treating cancer.
Abstract: The invention provides new polymorphs of N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3 -(methoxymethyl)-1-({4-[(2-oxopyridin-1-yl)methyl]phenyl}methyl)pyrazole-4-carboxamide and salts thereof, pharmaceutical compositions containing them and their use in therapy.
Type:
Grant
Filed:
October 20, 2021
Date of Patent:
August 29, 2023
Assignee:
KalVista Pharmaceuticals Limited
Inventors:
Haydn Beaton, David Malcolm Crowe, Hannah Joy Edwards