Patents Assigned to Ischemia Technologies, Inc.
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Patent number: 7473558Abstract: The present invention teaches a marker useful for detection and measurement of free radical damage. Specifically, the invention takes advantage of alterations which occur to the N-terminus of the albumin molecule, a circulating protein in human blood, in the presence of free radicals. These alterations affect the ability of the N-terminus of the albumin molecule to bind metals. Methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of an albumin containing sample, analysis and measurement of the ability of albumin to bind exogenous cobalt, detection and measurement of the presence of copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following free radical damage.Type: GrantFiled: August 30, 2002Date of Patent: January 6, 2009Assignee: Ischemia Technologies, Inc.Inventors: David Bar-Or, Edward Lau
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Patent number: 7449338Abstract: The present invention relates to rapid methods for the detection of ischemic states and to kits for use in such methods. Provided for is a rapid method of testing for and quantifying ischemia based upon methods of detecting and quantifying the existence of an alteration of the serum protein albumin which occurs following an ischemic event; methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of circulating albumin, analysis and measurement of the ability of serum albumin to bind exogenous cobalt, detection and measurement of the presence of endogenous copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following an ischemic event.Type: GrantFiled: December 13, 2002Date of Patent: November 11, 2008Assignee: Ischemia Technologies, Inc.Inventors: David Bar-Or, Edward Lau, James V. Winkler, Gary Fagan, Hollie Wayment
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Patent number: 7297544Abstract: The present invention relates to rapid methods for the detection of ischemic states and to kits for use in such methods. Provided for is a rapid method of testing for and quantifying ischemia based upon methods of detecting and quantifying the existence of an alteration of the serum protein albumin which occurs following an ischemic event; methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of circulating albumin, analysis and measurement of the ability of serum albumin to bind exogenous cobalt, detection and measurement of the presence of endogenous copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following an ischemic event.Type: GrantFiled: April 15, 2003Date of Patent: November 20, 2007Assignee: Ischemia Technologies, Inc.Inventors: David Bar-Or, Edward Lau, James V. Winkler
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Patent number: 7282369Abstract: The present invention relates to rapid methods for the detection of ischemic states and to kits for use in such methods. Provided for is a rapid method of testing for and quantifying ischemia based upon methods of detecting and quantifying the existence of an alteration of the serum protein albumin which occurs following an ischemic event; methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of circulating albumin, analysis and measurement of the ability of serum albumin to bind exogenous cobalt, detection and measurement of the presence of endogenous copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following an ischemic event.Type: GrantFiled: April 15, 2003Date of Patent: October 16, 2007Assignee: Ischemia Technologies, Inc.Inventors: David Bar-Or, Edward Lau, James V Winkler
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Publication number: 20070231847Abstract: The present invention teaches a marker useful for detection and measurement of free radical damage. Specifically, the invention takes advantage of alterations which occur to the N-terminus of the albumin molecule, a circulating protein in human blood, in the presence of free radicals. These alterations effect the ability of the N-terminus of the albumin molecule to bind metals. Methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of an albumin-containing sample, analysis and measurement of the ability of albumin to bind exogenous cobalt, detection and measurement of the presence of copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following free radical damage.Type: ApplicationFiled: January 31, 2005Publication date: October 4, 2007Applicant: Ischemia Technologies, Inc.Inventors: David Bar-Or, Edward Lau
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Publication number: 20060191788Abstract: The subject invention comprises electrochemical methods and devices for in vitro detection of an ischemic event in a patient sample. Following addition of a known amount of a transition metal ion to the patient sample, electrodes are used to measure the current or potential difference of non-sequestered transition metal ion in the sample. The amount of non-sequestered transition metal ion in the sample reflects the degree of modification to albumin that is the result of an ischemic event.Type: ApplicationFiled: May 1, 2006Publication date: August 31, 2006Applicant: Ischemia Technologies, Inc.Inventors: Hollie Wayment, Gary Fagan, Peter Crosby, Shannon George
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Apparatus and method for risk stratification of patients with chest pain of suspected cardiac origin
Patent number: 7074194Abstract: The subject invention relates to the detection, diagnosis and risk stratification of clinical events such as acute coronary syndrome, in patients with signs and symptoms of suspected cardiac origin. In one embodiment, a clinical event in a patient is diagnosed by obtaining the patient's ECG, and at least one in vitro diagnostic assay, preferably an assay for a marker of ischemia, and optionally in vitro diagnostic assays for necrotic markers or other cardiac indicators, and combining the foregoing results in an algorithm to provide a diagnosis or a risk stratification of the clinical condition.Type: GrantFiled: May 19, 2003Date of Patent: July 11, 2006Assignee: Ischemia Technologies, Inc.Inventors: Peter A. Crosby, Deborah L. Morris, Mark M. Soane -
Patent number: 7070937Abstract: The present invention teaches a marker useful for detection and measurement of free radical damage. Specifically, the invention takes advantage of alterations which occur to the N-terminus of the albumin molecule, a circulating protein in human blood, in the presence of free radicals. These alterations effect the ability of the N-terminus of the albumin molecule to bind metals. Methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of an albumin-containing sample, analysis and measurement of the ability of albumin to bind exogenous cobalt, detection and measurement of the presence of copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following free radical damage.Type: GrantFiled: March 29, 2001Date of Patent: July 4, 2006Assignee: Ischemia Technologies, Inc.Inventors: David Bar-Or, Edward Lau
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Publication number: 20060135875Abstract: The subject invention relates to the detection, diagnosis and risk stratification of clinical events such as acute coronary syndrome, in patients with signs and symptoms of suspected cardiac origin. In one embodiment, a clinical event in a patient is diagnosed by obtaining the patient's ECG, and at least one in vitro diagnostic assay, preferably an assay for a marker of ischemia, and optionally in vitro diagnostic assays for necrotic markers or other cardiac indicators, and combining the foregoing results in an algorithm to provide a diagnosis or a risk stratification of the clinical condition.Type: ApplicationFiled: December 22, 2005Publication date: June 22, 2006Applicant: ISCHEMIA TECHNOLOGIES, INC.Inventors: Peter Crosby, Deborah Morris, Mark Soane
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Patent number: 7063782Abstract: The subject invention comprises electrochemical methods and devices for in vitro detection of an ischemic event in a patient sample. Following addition of a known amount of a transition metal ion to the patient sample, electrodes are used to measure the current or potential difference of non-sequestered transition metal ion in the sample. The amount of non-sequestered transition metal ion in the sample reflects the degree of modification to albumin that is the result of an ischemic event.Type: GrantFiled: November 26, 2002Date of Patent: June 20, 2006Assignee: Ischemia Technologies, Inc.Inventors: Hollie Wayment, Gary Fagan, Peter A. Crosby, Shannon George
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Patent number: 6770487Abstract: Diagnostic test devices, including diagnostic strip tests, are provided in which identifying information and the test result are machine-readable. Also provided are methods for obtaining identifying information and test results from the diagnostic test devices.Type: GrantFiled: May 1, 2001Date of Patent: August 3, 2004Assignee: Ischemia Technologies, Inc.Inventor: Peter A. Crosby
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Publication number: 20030215359Abstract: The present invention relates to rapid methods for the detection of ischemic states and to kits for use in such methods. Provided for is a rapid method of testing for and quantifying ischemia based upon methods of detecting and quantifying the existence of an alteration of the serum protein albumin which occurs following an ischemic event; methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of circulating albumin, analysis and measurement of the ability of serum albumin to bind exogenous cobalt, detection and measurement of the presence of endogenous copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following an ischemic event.Type: ApplicationFiled: April 15, 2003Publication date: November 20, 2003Applicant: ISCHEMIA TECHNOLOGIES, INC.Inventors: David Bar-Or, Edward Lau, James V. Winkler
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Publication number: 20030215952Abstract: The present invention relates to rapid methods for the detection of ischemic states and to kits for use in such methods. Provided for is a rapid method of testing for and quantifying ischemia based upon methods of detecting and quantifying the existence of an alteration of the serum protein albumin which occurs following an ischemic event; methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of circulating albumin, analysis and measurement of the ability of serum albumin to bind exogenous cobalt, detection and measurement of the presence of endogenous copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following an ischemic event.Type: ApplicationFiled: April 15, 2003Publication date: November 20, 2003Applicant: Ischemia Technologies, Inc.Inventors: David Bar-Or, Edward Lau, James V. Winkler
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Publication number: 20030194813Abstract: The present invention relates to rapid methods for the detection of ischemic states and to kits for use in such methods. Provided for is a rapid method of testing for and quantifying ischemia based upon methods of detecting and quantifying the existence of an alteration of the serum protein albumin which occurs following an ischemic event; methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of circulating albumin, analysis and measurement of the ability of serum albumin to bind exogenous cobalt, detection and measurement of the presence of endogenous copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following an ischemic event.Type: ApplicationFiled: April 15, 2003Publication date: October 16, 2003Applicant: Ischemia Technologies, Inc.Inventors: David Bar-Or, Edward Lau, James V. Winkler
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Publication number: 20030132125Abstract: The subject invention comprises electrochemical methods and devices for in vitro detection of an ischemic event in a patient sample. Following addition of a known amount of a transition metal ion to the patient sample, electrodes are used to measure the current or potential difference of non-sequestered transition metal ion in the sample. The amount of non-sequestered transition metal ion in the sample reflects the degree of modification to albumin that is the result of an ischemic event.Type: ApplicationFiled: November 26, 2002Publication date: July 17, 2003Applicant: Ischemia Technologies Inc.Inventors: Hollie Wayment, Gary Fagan, Peter A. Crosby, Shannon George
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Publication number: 20030017506Abstract: The present invention teaches a marker useful for detection and measurement of free radical damage. Specifically, the invention takes advantage of alterations which occur to the N-terminus of the albumin molecule, a circulating protein in human blood, in the presence of free radicals. These alterations effect the ability of the N-terminus of the albumin molecule to bind metals. Methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of an albumin containing sample, analysis and measurement of the ability of albumin to bind exogenous cobalt, detection and measurement of the presence of copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following free radical damage.Type: ApplicationFiled: August 30, 2002Publication date: January 23, 2003Applicant: Ischemia Technologies, Inc.Inventors: David Bar-Or, Edward Lau
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Patent number: 6475743Abstract: The present invention teaches a marker useful for detection and measurement of free radical damage. Specifically, the invention takes advantage of alterations which occur to the N-terminus of the albumin molecule, a circulating protein in human blood, in the presence of free radicals. These alterations effect the ability of the N-terminus of the albumin molecule to bind metals. Methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of an albumin containing sample, analysis and measurement of the ability of albumin to bind exogenous cobalt, detection and measurement of the presence of copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following free radical damage.Type: GrantFiled: October 2, 1998Date of Patent: November 5, 2002Assignee: Ischemia Technologies, Inc.Inventors: David Bar-Or, Edward Lau
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Patent number: 6461875Abstract: The present invention relates to a rapid method for the detection of ischemic states and to a kit for use in such a method. Provided for is a rapid method of testing for the existence of and quantifying ischemia based upon method of detecting and quantifying the existence of an alteration of the serum protein albumin which occurs following an ischemic event; methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of circulating blood, analysis and measurement of the ability of serum albumin to bind exogenous cobalt, detection and measurement of the presence of copper in a purified albumin sample and use of an immunological assay sepcific to the alterated form of serum albumin which occurs following an ischemic event.Type: GrantFiled: October 2, 1998Date of Patent: October 8, 2002Assignee: Ischemia Technologies, Inc.Inventors: David Bar-Or, Edward Lau, James V. Winkler