Patents Assigned to Isis Innovation Limited
  • Patent number: 10545113
    Abstract: Electrochemical detection method and related aspects Herein is disclosed an electrochemical test method comprising (i) comparing how a plurality of immittance functions and/or components thereof vary with a change in a parameter of interest for a first system, and then selecting an immittance function or component thereof for use in an electrochemical test; (ii) carrying out an electrochemical test step for a second system to determine at least one value for the immittance function or component thereof selected in step (i), and then, by using a quantitative relationship between the selected immittance function and the parameter of interest, determining a value in the parameter of interest. A computer program and apparatus are also disclosed herein.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: January 28, 2020
    Assignees: ISIS Innovation Limited, Universidade Estadual Paulista “Julio de Mequita Filho”
    Inventors: Jason Davis, Jr., Paulo Roberto Bueno
  • Patent number: 10501727
    Abstract: This invention relates to mutant enzymes with enhanced properties and processes for oxidation of organic compound substrates using such enzymes.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: December 10, 2019
    Assignee: ISIS INNOVATION LIMITED
    Inventors: Luet Lok Wong, Stephen Graham Bell, Christopher Whitehouse
  • Patent number: 10162031
    Abstract: The present disclosure provides systems and methods which may assist in evaluating liver fibrosis/inflammation in the presence of elevated iron using magnetic resonance relaxometry. In a non-limiting embodiment, the systems and methods include: obtaining a measurement of relaxometry data of a subject's liver for extracellular fluid, preferably using a magnetic resonance imaging (MRI) device; determining an iron content for the liver; simulating a measurement of the subject's liver for extracellular fluid for the determined iron content; comparing the measurement of the subject's liver for extracellular fluid to the simulated measurement of the subject's liver for extracellular fluid; and determining from said comparison a value of extracellular fluid in the subject's liver based on a normal iron content for the liver.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: December 25, 2018
    Assignee: ISIS INNOVATION LIMITED
    Inventors: Elizabeth Tunnicliffee, Matthew Robson, Rajarshi Banerjee
  • Publication number: 20180143282
    Abstract: The present invention relates to methods of assessing or obtaining an indication of the presence of a cognitive disorder by analysing microstructural changes in regions of the brain. The invention particularly relates to methods of assessing or obtaining an indication of the presence of types of dementia, for example Alzheimer's disease, by analysing changes in minicolumns in regions or layers of the cortex of the brain or of the whole brain.
    Type: Application
    Filed: April 7, 2016
    Publication date: May 24, 2018
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Steven Chance, Rebecca McKavanagh, Mark Jenkinson, Karla Miller
  • Patent number: 9957563
    Abstract: This invention relates to a method of determining the susceptibility of an individual to statin-induced myopathy, comprising detecting the presence or absence of one or more polymorphisms in the SLCO1B1 gene in a biological sample from an individual, whereby the presence of one or more polymorphisms indicates that the individual has altered susceptibility to statin-induced myopathy.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: May 1, 2018
    Assignee: Isis Innovation Limited
    Inventors: Emma Link, Sarah Parish, Rory Collins, Mark Lathrop
  • Patent number: 9945775
    Abstract: A sensor comprises a pair of mirrors (11, 12) opposed along an optical axis and shaped to provide an optical cavity with stable resonance in at least one mode and having a cavity length of at most 50 ?m. An actuator system is arranged to move the mirrors relative to each other along the length of the optical cavity for tuning the wavelength of the mode of said cavity. A chemical sample is introduced inside the optical cavity using a sample introduction system (21). An EM radiation source (20) illuminates the cavity and a detector (25) detects the EM radiation emitted from, transmitted through, or reflected from the optical cavity.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: April 17, 2018
    Assignee: ISIS INNOVATION LIMITED
    Inventors: Jason Michael Smith, Claire Vallance
  • Patent number: 9941933
    Abstract: A magneto-inductive waveguide comprising a plurality of resonant elements, the plurality of resonant elements including a first resonant element comprising a conductive loop broken by at least one capacitive gap, and a second resonant element comprising a conductive loop broken by at least one capacitive gap, the second resonant element for magneto-inductively coupling with the first resonant element; wherein the first resonant element and second resonant element are conductively coupled.
    Type: Grant
    Filed: June 18, 2012
    Date of Patent: April 10, 2018
    Assignee: ISIS INNOVATION LIMITED
    Inventor: Christopher Stevens
  • Patent number: 9864927
    Abstract: A method of detecting the structural elements within a scene sensed by at least one sensor within a locale, the method comprising: a) capturing data from the sensor, which data provides a first representation of the sensed scene at the current time; b) generating a second representation of the sensed scene where the second representation is generated from a prior model of the locale; and c) comparing the first and second representations with one another to determine which parts of the first representation represent structural elements of the locale.
    Type: Grant
    Filed: January 20, 2014
    Date of Patent: January 9, 2018
    Assignee: Isis Innovation Limited
    Inventors: Colin Alexander McManus, Paul Michael Newman, Benjamin Charles Davis
  • Publication number: 20170298445
    Abstract: A method of investigating the monotypia of a population of T-cells comprising detecting expression of the T cell receptor beta chain constant region TRBC1 and TRBC2, and/or the T cell receptor gamma chain constant region TRGC1 and TRGC, in a population of T-cells.
    Type: Application
    Filed: October 2, 2015
    Publication date: October 19, 2017
    Applicant: ISIS Innovation Limited
    Inventor: Graham Ogg
  • Patent number: 9773160
    Abstract: Images are searched to locate faces that are the same as a query face. Images that include a face that is the same as the query face may be presented to a user as search result images. Images also may be sorted by the faces included in the images and presented to the user as sorted search result images. The user may provide explicit or implicit feedback regarding the search result images. Additional feedback may be inferred regarding the search result images based on the user-provided feedback, and the results may be updated based on the user-provided and inferred feedback.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: September 26, 2017
    Assignees: AOL Inc., California Institute of Technology, Isis Innovation Limited
    Inventors: Keren O Perlmutter, Sharon M Perlmutter, Joshua Alspector, Mark Everingham, Alex Holub, Andrew Zisserman, Pietro Perona
  • Patent number: 9659229
    Abstract: An image of a human, animal or machine subject, is analysed to detect regions which include strong periodic intensity variations, such as a photoplethysmogram (PPG) signal in a human or animal, or some periodic vibration in a machine. The image is divided into plural regions of fixed order is fitted to a representative intensity signal for that region. The poles of the fitted autoregressive model are thresholded by magnitude to select only the pole or poles with a magnitude greater than the threshold. The pole magnitude therefore acts as a signal quality index. The dominant pole is representative of the strongest periodic information and the frequency of that spectral component can be derived from the phase angle of the pole. The image may be redisplayed with image attributes, e.g. color-coding, according to the pole magnitude in each region of interest and/or the dominant pole phase angle in each region of interest. In the case of a PPG image signal this can give maps of heart rate and breathing rate.
    Type: Grant
    Filed: January 28, 2014
    Date of Patent: May 23, 2017
    Assignee: ISIS INNOVATION LIMITED
    Inventors: David Andrew Clifton, Mauricio Christian Villarroel Montoya, Lionel Tarassenko
  • Patent number: 9638909
    Abstract: A focusing apparatus for use with an optical system having a high NA objective lens includes an image forming and capturing mechanism for forming an image in an intermediate image zone and for capturing an image by receiving and refocusing light from a selected focal plane within the intermediate image zone, and a focus adjusting mechanism for adjusting the position of the selected focal plane within the intermediate image zone. The image forming and capturing mechanism includes at least one high NA lens. In use, spherical aberration introduced by the high NA objective lens is reduced.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: May 2, 2017
    Assignee: ISIS INNOVATION LIMITED
    Inventors: Tony Wilson, Rimvydas Juskaitis, Martin James Booth, Edward Botcherby
  • Patent number: 9615749
    Abstract: A method of remote monitoring of vital signs by detecting the PPG signal in an image of a subject taken by a video camera such as a webcam. The PPG signal is identified by auto-regressive analysis of ambient light reflected from a region of interest on the subject's skin. Frequency components of the ambient light and aliasing artefacts resulting from the frame rate of the video camera are cancelled by auto-regressive analysis of ambient light reflected from a region of interest not on the subject's skin, e.g. in the background. This reveals the spectral content of the ambient light allowing identification of the subject's PPG signal. Heart rate, oxygen saturation and breathing rate are obtained from the PPG signal. The values can be combined into a wellness index based on a statistical analysis of the values.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: April 11, 2017
    Assignee: ISIS INNOVATION LIMITED
    Inventors: David Andrew Clifton, Mauricio Christian Villarroel Montoya, Lionel Tarassenko
  • Publication number: 20170031231
    Abstract: A display device comprises a plurality of pixels, each pixel having a portion (10) of a solid-state, phase-change material such as germanium-antimonium-telluride (GST) or vanadium dioxide, wherein the phase-change material can be reversibly brought into an amorphous state or a crystaline state and has a refractive index that is reversibly, electrically controllable. A plurality of electrodes (14, 16) are provided, at least two of which contact said portion of material (10). A controller (19) is provided that is adapted to apply at least one voltage to said material (10), via said electrodes (14, 16), to change said refractive index. An array of such portions of material can be arranged to make a pixellated display, for example a stereoscopic display of the volumetric type.
    Type: Application
    Filed: December 22, 2014
    Publication date: February 2, 2017
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Harish BHASKARAN, Peiman HOSSEINI
  • Publication number: 20170010266
    Abstract: New sarcoma cell surface targets have been identified and include LINGO-1, KCNN1 and CDH23. Specific binding agents that specifically bind to these targets include antibodies and aptamers. Methods of treating sarcoma utilize the specific binding agents. Methods of diagnosing and detecting sarcoma, including metastases and residual disease involve determining the expression of LINGO-1, KCNN1 and CDH23.
    Type: Application
    Filed: February 17, 2015
    Publication date: January 12, 2017
    Applicant: ISIS Innovation Limited
    Inventors: Terrence Rabbitts, Jennifer Town, Helio Pais
  • Publication number: 20160380125
    Abstract: The present invention relates to devices comprising metal halide perovskites and organic passivating agents. In particular, the invention relates to photovoltaic and optoelectronic devices comprising passivated metal halide perovskites. The device according to the invention comprises: (a) a metal halide perovskite; and (b) a passivating agent which is an organic compound; wherein molecules of the passivating agent are chemically bonded to anions or cations in the metal halide perovskite.
    Type: Application
    Filed: December 17, 2014
    Publication date: December 29, 2016
    Applicant: Isis Innovation Limited
    Inventors: Henry J. Snaith, Antonio Abate, Nakita K. Noel
  • Patent number: 9528467
    Abstract: Stirling cycle machines, including engines and coolers or heat pumps are described.
    Type: Grant
    Filed: January 7, 2013
    Date of Patent: December 27, 2016
    Assignee: Isis Innovation Limited
    Inventor: Michael William Dadd
  • Publication number: 20160343884
    Abstract: Methods of manufacturing a substrate unit that achieve improved levels of efficiency and/or longevity are disclosed. The substrate units may be used for example in solar cells, semiconductor detectors or electrostatic actuators, sensors, harvesters or other electro-mechanical devices. Disclosed methods include the steps of generating, or redistributing into the bulk of the dielectric film, a region of net charge in the dielectric film while the dielectric film is at a temperature greater than 150° C.
    Type: Application
    Filed: December 19, 2014
    Publication date: November 24, 2016
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Peter WILSHAW, Ruy Sebastian BONILLA OSORIO
  • Publication number: 20160327556
    Abstract: The invention relates to a method of determining the inflammatory disorder status of a subject comprising detecting the presence or absence, or the level, of (i) citrullinated tenascin-C and/or one or more fragments of citrullinated tenascin-C; and/or (ii) autoantibodies with specificity for citrullinated tenascin-C and/or one or more fragments of citrullinated tenascin-C, in a sample from said subject.
    Type: Application
    Filed: January 13, 2015
    Publication date: November 10, 2016
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Kim Suzanne Midwood, Patrick John Venables
  • Publication number: 20160324921
    Abstract: A method of treating an eye disease comprising administering an adeno-associated virus (AAV) vector to a mammalian subject by subretinal injection, wherein the AAV vector comprises a nucleotide sequence encoding melanopsin operably linked to an expression control sequence to promote expression of melanopsin in cells of the eye of the subject.
    Type: Application
    Filed: May 5, 2015
    Publication date: November 10, 2016
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Robert E. MacLaren, Alun R. Barnard, Samantha R. De Silva, Mark W. Hankins