Patents Assigned to Isis Innovation Limited
  • IMAGE CAPTURE DEVICE AND METHOD
    Publication number: 20120257101
    Abstract: An image capture device including a sensor having an active area including a plurality of pixels and a shutter array for controlling the exposure of individual pixels. The pixels are grouped in a plurality of pixel subsets and are arranged to capture a plurality of time-separated lo-res images, which can be viewed sequentially as a movie or combined to form a hi-res still image.
    Type: Application
    Filed: June 18, 2012
    Publication date: October 11, 2012
    Applicant: ISIS INNOVATION LIMITED
    Inventor: Gil Bub
  • ULTRASOUND SYSTEMS
    Publication number: 20120259222
    Abstract: An ultrasound system comprises a transducer, a controller arranged to generate control signals arranged to control the transducer to generate pressure waves directed at a target volume, and sensing means arranged to sense cavitation in the target volume. The controller is arranged to receive sensing signals from the sensing means and to vary the control signals in response to the sensing signals thereby to control the cavitation.
    Type: Application
    Filed: September 20, 2010
    Publication date: October 11, 2012
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Constantin Coussios, Manish Arora, Natalie Hockham, Ronald Aurele Roy
  • Materials and methods relating to improved vaccination strategies
    Patent number: 8282935
    Abstract: The invention provides novel vaccination strategies based on a prime-boost vaccination regiment. The inventors have determined improved ways of boosting an immune response in a patient previously primed or exposed to a plurality of epitopes. The improved method requires the epitopes in the boosting phase to be administered individually, i.e. held on separate peptide constructs.
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: October 9, 2012
    Assignee: ISIS Innovation Limited
    Inventors: Vincenzo Cerundolo, Michael J. Palmowski, Edward Man-Lik Choi
  • Formation of bilayers of amphipathic molecules
    Patent number: 8268627
    Abstract: A method of forming bilayers of amphipathic molecules uses droplets of aqueous solution in a hydrophobic medium such as oil. A layer of amphipathic molecules such as a lipid is formed around the surfaces of the droplets. This may be achieved by providing the lipid in the oil and leaving the droplets for a time sufficient to form the layer. The droplets are brought into contact with one another so that a bilayer of the amphipathic molecules is formed as an interface between the contacting droplets. The bilayers may be used for a wide range of studies. The technique has numerous advantages including providing a long lifetime for the bilayers, allowing study of small volumes and allowing the construction of chains and networks of droplets with bilayers in between to study complex systems.
    Type: Grant
    Filed: July 26, 2007
    Date of Patent: September 18, 2012
    Assignee: ISIS Innovation Limited
    Inventors: John Hagen Pryce Bayley, Matthew Holden, Andrew John Heron, David Needham
  • BILAYERS
    Publication number: 20120220481
    Abstract: A method for producing a bilayer, the method comprising: (a) providing a hydrated support and a hydrophilic body immersed in a hydrophobic medium; wherein a first monolayer of amphipathic molecules is formed on an interface between the hydrophobic medium and the hydrophilic body and a second monolayer of amphipathic molecules is formed on an interface between the hydrophobic medium and the hydrated support; and (b) bringing the first monolayer into contact with the second monolayer to form a bilayer of amphipathic molecules, wherein at least part of a cell membrane, comprising cell membrane constituents, is provided in or on the hydrated support and/or in the hydrophilic body, and such that constituents of the cell membrane incorporate into the bilayer during or after the bilayer formation. A bilayer produced by the method of the invention, and uses of the bilayer.
    Type: Application
    Filed: August 4, 2010
    Publication date: August 30, 2012
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Mark Ian Wallace, Sebastian Leptihn, James Russell Thompson
  • METHODS USING PORES
    Publication number: 20120219960
    Abstract: The invention relates to a method of identifying an individual nucleotide, comprising (a) contacting the nucleotide with a transmembrane protein pore so that the nucleotide interacts with the pore and (b) measuring the current passing through the pore during the interaction and thereby determining the identity of the nucleotide. The invention also relates to a method of sequencing nucleic acid sequences and kits related thereto.
    Type: Application
    Filed: December 28, 2011
    Publication date: August 30, 2012
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Hagan BAYLEY, Yann ASTIER, Orit BRAHA
  • HETEROJUNCTION DEVICE
    Publication number: 20120216865
    Abstract: A solid-state p-n heterojunction comprising an organic p-type material in contact with an n-type material wherein said n-type material is surface-sensitised by at least two sensitizing agents comprising an energy donor sensitizing agent and an energy acceptor sensitizing agent and optionally at least one intermediate sensitizing agent, wherein the emission spectrum of the donor sensitizing agent overlaps with the absorption spectrum of the acceptor sensitizing agent and/or at least one intermediate sensitizing agent where present, and the emission spectrum of at least one intermediate sensitizing agent where present overlaps with the absorption spectrum of the acceptor sensitizing agent and wherein the acceptor sensitizing agent individually has a maximum Absorbed Photon to electron Conversion Efficiency of no less than 40% in an equivalent heterojunction when used as sole sensitizing agent.
    Type: Application
    Filed: September 13, 2010
    Publication date: August 30, 2012
    Applicant: ISIS INNOVATION LIMITED
    Inventor: Henry J. Snaith
  • Composite Materials Containing Aligned Nanotubes and the Production Thereof
    Publication number: 20120208002
    Abstract: According to the present invention, there is provided a method of forming a composite material comprising nanotubes oriented in a matrix comprising a ceramic material, the method comprising the steps of: providing an array of substantially aligned nanotubes; providing a ceramic matrix material in the form of a solution; applying the solution to the nanotubes; allowing the solution to infiltrate into the array of nanotubes; and sintering the ceramic matrix material to form the composite material, wherein the nanotubes are substantially aligned in the ceramic matrix. Composite materials obtainable by said method are also provided.
    Type: Application
    Filed: August 25, 2010
    Publication date: August 16, 2012
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Richard Ian Todd, Nicole Grobert, Geoffrey Otieno
  • Method for producing dendritic cells
    Patent number: 8232100
    Abstract: Disclosed are embryonic stem cell-derived dendritic cells, genetically modified immature dendritic cells capable of maturation, as well as methods for the production of such cells. In one embodiment, the cells made be produced by a method comprising the steps of providing a population of embryonic stem cells; culturing the embryonic stem cells in the presence of a cytokine or combination of cytokines which brings about differentiation of the embryonic stem cells into dendritic cells; and recovering the dendritic cells from the culture. In a further embodiment, the cells may be genetically modified.
    Type: Grant
    Filed: July 21, 2010
    Date of Patent: July 31, 2012
    Assignee: Isis Innovation Limited
    Inventors: Herman Waldmann, Paul J. Fairchild, Richard Gardner, Frances Brook
  • Security in computing networks
    Patent number: 8230229
    Abstract: A system for verifying the security of communications between a set of nodes via a high-bandwidth, insecure communications channel. A number of embodiments are described for enabling authenticated communication between the nodes in an environment wherein there is a high bandwidth Dolev-Yao network amongst the nodes and non-spoofable, low-bandwidth empirical channels between each pair of nodes.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: July 24, 2012
    Assignee: ISIS Innovation Limited
    Inventors: Andrew William Roscoe, Long Hoang Nguyen
  • OLEFIN METATHESIS REACTIONS OF AMINO ACIDS, PEPTIDES AND PROTEINS CONTAINING ALLYL SULFIDE GROUPS
    Publication number: 20120178913
    Abstract: A method for the modification of an amino acid, protein or peptide is disclosed. The method comprises reacting a carbon-carbon double bond-containing compound with an amino acid, a protein or a peptide containing an allyl sulfide group in the presence of a catalyst which promotes olefin metathesis, to form a modified amino acid, protein or peptide. Preferred carbon-carbon double bond-containing compounds include carbohydrates.
    Type: Application
    Filed: June 5, 2009
    Publication date: July 12, 2012
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Yuya Angel Lin, Justin Mark Chalker, Benjamin Guy Davis
  • Organic phosphorescent material and organic optoelectronic device
    Patent number: 8216699
    Abstract: The invention provides a cyclometallated complex comprising the structure of formula I wherein: M is a d-block transition metal; B is a five- or six-membered aryl or heteroaryl ring which is optionally substituted and optionally fused to one or more other aryl or heteroaryl rings; A is a five- or six-membered heteroaryl ring comprising at least three nitrogen atoms; R1 is a group other than hydrogen; n is zero or an integer equal to or greater than one; and A and B are optionally fused or linked by one or more covalent bonds. The invention also provides the use of such complexes in optoelectronic devices, and in particular in organic light emitting devices.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: July 10, 2012
    Assignee: Isis Innovation Limited
    Inventors: Paul Leslie Burn, Ifor David William Samuel, Shih-Chun Lo
  • Tuberculosis diagnostic test
    Patent number: 8216795
    Abstract: A method of diagnosing in a host infection by or exposure to a mycobacterium which expresses ESAT-6 comprising (i) contacting a population of T cells from the host with one or more peptides or analogues selected from the peptides represented by SEQ ID NO:1 to 11 and analogues thereof which can bind a T cell receptor which recognizes any of the said peptides, and (ii) determining whether the T cells of said T cell population recognize the peptide(s) and/or analogue(s). The method may performed in vivo. Peptides and a kit which enable the method to be carried out are provided.
    Type: Grant
    Filed: January 25, 2011
    Date of Patent: July 10, 2012
    Assignee: Isis Innovation Limited
    Inventors: Ajit Lalvani, Ansar Pathan
  • Atomic clock
    Patent number: 8217724
    Abstract: An atomic clock comprises endohedral fullerene systems which provide the standard frequency oscillations. A magnet device applies a magnetic field to the endohedral fullerenes. The applied magnetic field is adjustable. An excitation device both excites each endohedral fullerene system to cause it to undergo transitions which generate the time-keeping oscillations, and also probes the systems such that the oscillations can be measured and the device controlled. A detection device senses the response of the systems induced by the excitation device. The output of the detection device is fed to a controller. The controller produces the atomic clock output, which is the clock signal or frequency standard, and also controls the magnet device and the excitation device.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: July 10, 2012
    Assignee: Isis Innovation Limited
    Inventors: George Andrew Davidson Briggs, Arzhang Ardavan
  • SOLID STATE HETEROJUNCTION DEVICE
    Publication number: 20120146007
    Abstract: The present invention provides a solid-state p-n heterojunction comprising a p-type material in contact with an n-type material wherein said n-type material comprises SnO2 having at least one surface-coating of a surface coating material having a higher band-gap than SnO2 and/or a conduction band edge closer to vacuum level than SnO2, such as MgO. The invention also provides optoelectronic devices such as solar cells or photo sensors comprising such a p-n heterojunction, and methods for the manufacture of such a heterojunction or device.
    Type: Application
    Filed: June 8, 2010
    Publication date: June 14, 2012
    Applicant: ISIS INNOVATION LIMITED
    Inventor: Henry J. Snaith
  • Vaccine
    Publication number: 20120121646
    Abstract: The invention relates to a vaccine for the treatment of disease caused by Neisseria, the vaccine including one or more immunogenic components for Neisseria serogroups, as well as antibodies to the immunogenic components and methods of preventing and treating Neisseria infections. The immunogens are based on elements of the inner core lipopolysaccharide.
    Type: Application
    Filed: December 7, 2011
    Publication date: May 17, 2012
    Applicant: Isis Innovation Limited
    Inventors: Joyce Susan Plested, Michael Paul Jennings, Margaret Ann Jaqueline Gidney, Andrew David Cox, James Clare Richards, Richard Edward Moxon
  • NEUROLOGICAL AUTOIMMUNE DISORDERS
    Publication number: 20120114666
    Abstract: The invention relates to a method of diagnosing an autoimmune neurological disorder in a mammal comprising the step of detecting, in a bodily fluid sample from the mammal, autoantibodies to an epitope of at least one Kv1-complex protein; and related methods, assay kits, isolated or purified autoantibody or antibody fragments, or uses thereof.
    Type: Application
    Filed: October 26, 2009
    Publication date: May 10, 2012
    Applicant: ISIS INNOVATION LIMITED
    Inventor: Angela Vincent
  • Vaccine
    Patent number: 8173798
    Abstract: The invention relates to a vaccine for the treatment of disease caused by Neisseria, the vaccine including one or more immunogenic components for Neisseria serogroups, as well as antibodies to the immunogenic components and methods of preventing and treating Neisseria infections. The immunogens are based on elements of the inner core lipopolysaccharide.
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: May 8, 2012
    Assignee: Isis Innovation Limited
    Inventors: Joyce Susan Plested, Michael Paul Jennings, Margaret Anne Jaqueline Gidney, Andrew David Cox, James Clare Richards, Richard Edward Moxon
  • METHOD FOR SEQUENCING A HETEROPOLYMERIC TARGET NUCLEIC ACID SEQUENCE
    Publication number: 20120107802
    Abstract: The invention relates to a method for sequencing a heteropolymeric target nucleic acid sequence that involves stochastic sensing. The invention also relates to a method for improving a pore for sequencing a target nucleic acid sequence by modifying one or more sites in the pore.
    Type: Application
    Filed: March 25, 2010
    Publication date: May 3, 2012
    Applicant: ISIS INNOVATION LIMITED
    Inventors: David Stoddart, Andrew John Heron, Giovanni Maglia, John Hagan Pryce Bayley
  • Mina53 assays
    Patent number: 8148100
    Abstract: The present invention comprises a method for assaying oxygenase activity the method comprising monitoring oxygenase activity of Mina53.
    Type: Grant
    Filed: September 25, 2006
    Date of Patent: April 3, 2012
    Assignee: ISIS Innovation Limited
    Inventors: Christopher Joseph Schofield, Michael Arnold McDonough, Nicolas Joseph Jean Granatino