Patents Assigned to ISIS Pharma GmbH
  • Patent number: 6365611
    Abstract: The invention relates to novel compounds derived from pentaerythrite compounds of formula (XII) and (XVI), which can be used as pharmaceutically active substances, specially in the treatment of cardiac and circulatory diseases.
    Type: Grant
    Filed: February 29, 2000
    Date of Patent: April 2, 2002
    Assignee: ISIS PHARMA GmbH
    Inventors: Gerd König, Ulrich Hess, Anne-Katrin Windeck, Holger Brosig
  • Patent number: 6180664
    Abstract: The invention describes novel compounds derived from pentaerythritol of general formula I, XIV, XVI, XIX and XXII, the substituents being as defined in the description, which can be used as pharmaceutical active substances, especially for the treatment of cardiovascular diseases.
    Type: Grant
    Filed: June 8, 1999
    Date of Patent: January 30, 2001
    Assignee: ISIS Pharma GmbH
    Inventors: Ulrich Hess, Anne-Katrin Windeck, Holger Brosig
  • Patent number: 5973011
    Abstract: The present invention describes the use of nitric-oxide-liberating or transferring compounds, stimulators of endogenous NO formation, as well as stimulators of guanylate cyclase, for prevention, treatment and elimination of endothelial dysfunctions and the diseases accompanying these dysfunctions or caused by them, as well as the use of said compounds to produce pharmaceutical products for the cited areas of application.
    Type: Grant
    Filed: September 27, 1996
    Date of Patent: October 26, 1999
    Assignee: ISIS PHARMA GmbH
    Inventors: Eike Albrecht Noack, Georg Kojda
  • Patent number: 5624960
    Abstract: An orally administrable drug formulation containing levodopa and carbidopa, and having a short release time, is disclosed. The formulation is useful in the treatment of Parkinson's disease.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 29, 1997
    Assignee: ISIS Pharma GmbH
    Inventors: Udo Wenzel, G unther Weber, J urgen Metzner, Alfred D arr, Sabine Freitag, Frank-Ulrich Fl other, Frank-Michael Albert, Margit Haase, Edith Leistner
  • Patent number: 5532274
    Abstract: A drug formulation administrable by mouth for the treatment of central dopamine deficiency condition, said formulation comprising100 to 250 parts by weight of levodopa,10 to 25 parts by weight of carbidopa,a polymer mixture in an amount of 10 to 200% based on said drugs, said polymer mixture consisting of:0 to 100 parts by weight of a completely saponified polyvinyl alcohol having 0 to 3% residual acetyl content, a mean molecular weight of 60,000 to 80,000 and a total surface area of 0.1 m.sup.2 /g to 0.18 m.sup.2 /g, and0 to 100 parts weight of a partially saponified polyvinyl alcohol having 10 to 18% residual acetyl content, a mean molecular weight of 80,000, a total surface area of 0.5 m.sup.2 /g to 0.69 m.sup.2 /g, and a specific pore volume of 0.2 cm.sup.3 /g to 0.36 cm.sup.3 /g,and an effective amount of customary galenic adjuvants.
    Type: Grant
    Filed: February 14, 1994
    Date of Patent: July 2, 1996
    Assignee: ISIS PHARMA GmbH
    Inventors: Udo Wenzel, Gunther Weber, Jurgen Metzner, Alfred Darr, Sabine Freitag, Frank-Ulrich Flother, Frank-Michael Albert, Margit Haase, Edith Leistner