Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, and phosphorodithioate covalent linkages. Also provided are synthetic intermediates useful in such processes.
Type:
Grant
Filed:
February 10, 1998
Date of Patent:
February 1, 2000
Assignee:
Isis Pharmeuticals, Inc.
Inventors:
Daniel C. Capaldi, Vasulinga T. Ravikumar