Abstract: The present invention relates to methods for deriving multipotent Isl1+ cells (i.e. methods for inducing a cell to enter a multipotent Isl1+ lineage), methods for differentiating Isl1+ cells to cardiac cells, cells obtainable by such methods, kits and compositions for carrying out the methods in accordance with the invention, and also medical applications and pharmaceutical compositions of said cells.
Type:
Grant
Filed:
July 11, 2013
Date of Patent:
March 12, 2019
Assignee:
IsletOne AB
Inventors:
Karl-Henrik Grinnemo, Oscar Simonson, Matthias Corbascio, Christer Sylvén, Eva Wärdell
Abstract: The present invention relates to methods for deriving multipotent Isl1+ cells (i.e. methods for inducing a cell to enter a multipotent Isl1+ lineage), methods for differentiating Isl1+ cells to cardiac cells, cells obtainable by such methods, kits and compositions for carrying out the methods in accordance with the invention, and also medical applications and pharmaceutical compositions of said cells.
Type:
Application
Filed:
July 11, 2013
Publication date:
June 18, 2015
Applicant:
IsletOne AB
Inventors:
Karl-Henrik Grinnemo, Oscar Simonson, Matthias Corbascio, Christer Sylvén, Eva Wärdell