Abstract: A radiolabeled lymphatic staining agent is mixed on site with a much larger amount, on a weight basis, of a non-radiolabeled lymphatic staining agent to form an injectable radiolabeled lymphatic staining agent suitable for surgical use in humans. Preferably, the radiolabel is I-125, because it has a 60-day half-life which enables it to be made off-site. The preferred radiolabeled lymphatic staining agent is iodinated methylene blue, because it can be mixed with a range of non-radioactive lymphatic staining agents, for example isosulfan blue, methylene blue, patent blue, and patent blue V, to provide the injected agent with sufficient radioactivity to enable machine detection. A method for making radioiodinated methylene blue is also disclosed.
Type:
Grant
Filed:
July 2, 2004
Date of Patent:
December 3, 2013
Assignee:
Iso-Tex Diagnostics, Inc
Inventors:
Thomas J. Maloney, Arthur E. Camp, Jr., Jesse J. Hernandez
Abstract: Undesirable metal cation contaminants, including hafnium, can be reduced from a solution containing Lutetium-177 on a bed of an anion exchange resin. The thus purified solution can be stored and transported in a polypropylene vial, to prevent the possibility of hafnium entering the solution from a glassware wall and of Lutetium from being lost from the solution by chemically reacting with a glassware wall. The vial can be sealed with a rubber stopper which has a polytetrafluoroethylene coating facing the solution to prevent the possibility of contaminants which could interfere with later uses of the Lutetium-177 from leaching into the solution from the rubber stopper. Recipients of the Lutetium-177-containing vial can be provided with a prepackaged column of the anion exchange resin to enable such recipients to remove the hafnium which accumulated in the solution as a product of radioactive decay during shipment.
Type:
Grant
Filed:
April 19, 2006
Date of Patent:
July 17, 2007
Assignee:
Iso-Tex Diagnostics, Inc.
Inventors:
Thomas J. Maloney, Arthur E. Camp, Jr., Jesse J. Hernandez, Jr.
Abstract: Undesirable metal cation contaminants, including cadmium, can be removed from a solution containing Indium-111, on a bed of an anion exchange resin. The thus purified solution can be stored and transported in a polypropylene vial, to prevent the possibility of cadmium entering the solution from a glassware wall and of Indium from being lost from the solution by chemically reacting with a glassware wall. The vial can be sealed with a rubber stopper which has a polytetrafluroethylene coating facing the solution to prevent the possibility of contaminants which could interfere with later uses of the Indium-111 from leaching into the solution from the rubber stopper. Recipients of the Indium-111-containing vial can be provided with a prepackaged column of the anion exchange resin to enable such recipients to remove the cadmium which accumulated in the solution as a product of radioactive decay during shipment.