Abstract: A method for increasing the molecular diversity of polyketides and non-ribosomal peptides by using recombination to efficiently increase or decrease the number of modules in the polyketide synthase or non-ribosomal peptide synthetase encoding the polyketide or peptide.
Type:
Grant
Filed:
July 9, 2014
Date of Patent:
May 22, 2018
Assignee:
ISOMERASE THERAPEUTICS, LTD.
Inventors:
Matthew Alan Gregory, Steven Gary Kendrew, Steven James Moss, Barrie Wilkinson
Abstract: A method for increasing the molecular diversity of polyketides and non-ribsomomal peptides by using recombination to efficiently increase or decrease the number of modules in the polyketide synthase or non-ribosomal peptide synthetase encoding said polyketide or peptide.
Type:
Application
Filed:
July 9, 2014
Publication date:
April 13, 2017
Applicant:
ISOMERASE THERAPEUTICS LTD.
Inventors:
Matthew Alan Gregory, Steven Gary Kendrew, Steven James Moss, Barrie Wikinson
Abstract: Novel rapamycin analogues and methods for their production with FKBP and/or MIP inhibitory activity with reduced mTOR inhibitory activity with therapeutic potential e.g. as bacterial virulence inhibitors.
Type:
Grant
Filed:
July 9, 2014
Date of Patent:
November 29, 2016
Assignee:
Isomerase Therapeutics Ltd.
Inventors:
Matthew Alan Gregory, Steven Gary Kendrew, Steven James Moss, Barrie Wilkinson