Abstract: The present invention relates to a method for coating a medical implant, wherein the implant is submersed in an aqueous solution of magnesium, calcium and phosphate ions through which a gaseous weak acid is passed, the solution is degassed, and the coating is allowed to precipitate onto the implant. The invention further relates to a medical implant coated in said method and to a device for use in said method.

Abstract: A device for bone tissue engineering is described which comprises a scaffold material consisting of a bioactive, osteoconductive and bone-bonding segmented thermoplastic copolyester and cultured osteogenic or osteoprogenitor cells, especially bone cells.

Abstract: The present invention relates to a method for coating a medical implant, wherein the implant is submersed in an aqueous solution of magnesium, calcium and phosphate ions through which a gaseous weak acid is passed, the solution is degassed, and the coating is allowed to precipitate onto the implant. The invention further relates to a medical implant coated in said method and to a device for use in said method.

Abstract: The invention relates to a method for in vitro production of bone tissue, comprising the steps of:(a) applying undifferentiated mammalian cells, in particular autologous marrow cells, on a substrate;(b) directly contacting said cells with a culture medium for a sufficient time to produce a continuous matrix;(c) removing the substrate with the matrix from the culture medium.The produced matrix can be used for joint prostheses, maxillofacial implants, special surgery devices, or bone fillers. The contacted culture medium can also be used for the production of active factors such as growth factors.

Abstract: The invention provides a nanotechnology process for implant surface treatment for producing an implant article. The nanotechnology process comprises subjecting a non-porous material to a mechanical or chemical surface treatment until a surface roughness with an average peak distance (Ra value) between 10 and 1,000 nm is obtained. The roughened surface can subsequently be subjected to precipitation of calcium phosphate from a solution containing calcium and phosphate ions.

Abstract: The invention provides an implantable device coated with a layer of calcium phosphate and optionally one or more biologically active substances such as growth factors, lipids, (lipo)polysaccharides, hormones, proteins, antibiotics or cytostatics. The device can be obtained by a nanotechnology process comprising subjecting a substrate to a surface treatment until a surface roughness with an average peak distance (Ra value) between 10 and 1,000 nm and subjecting the roughened surface to precipitation of calcium phosphate from a solution containing calcium and phosphate ions with optional coprecipitation of the biologically active substance.

Abstract: The invention provides an implantable device coated with a layer of calcium phosphate and optionally one or more biologically active substances such as growth factors, lipis, (lipo)polysaccharides, hormones, proteins, antibiotics or cytostatics. The device can be obtained by a nanotechnology process comprising subjecting a substrate to a surface treatment until a surface roughness with an average peak distance (Ra value) between 10 and 1,000 nm and subjecting the roughened surface to precipitation of calcium phosphate from a solution containing calcium and phosphate ions with optional coprepitation of the biologically active substance.

Abstract: The invention provides a nanotechnology process for implant surface treatment for producing an implant article. The nanotechnology process comprises subjecting a non-porous material to a mechanical or chemical surface treatment until a surface roughness with an average peak distance (Ra value) between 10 and 1,000 nm is obtained. The roughened surface can subsequently be subjected to precipitation of calcium phosphate from a solution containing calcium and phosphate ions.