Abstract: There is disclosed the reduction of alkyl esters of carbonic-carboxylic acid anhydrides at elevated temperature and pressure in the presence of platinum group metal catalysts, especially palladium on activated carbon, to make alcohols. Novel alkyl esters of carbonic-carboxylic acid anhydrides are disclosed, and can be used to make the corresponding alcohols, e.g., substituted benzyl alcohols. The alcohols can be converted to the corresponding halo, e.g., chloro, compounds. The substituted benzyl halides can be reacted with di(lower alkoxy)propionitriles, and the resulting 5-benzyl pyrimidines such as trimethoprim, 2,4-diamino-5-(3,4,5-trimethoxybenzyl)-pyrimidine, which is a known anti-bacterial agent, are especially useful in combination with sulfa drugs such as sulfamethoxazole.

Abstract: Compounds of the formula ##STR1## wherein A is alkylene, R.sub.1, R.sub.2, and R.sub.3 are hydrogen or lower alkoxy, and R.sub.4 is ##STR2## in which R.sub.5 and R.sub.6 are hydrogen or lower alkyl, with the proviso that at least one of R.sub.5 and R.sub.6 is lower alkyl, and >X is oxygen, ##STR3## or >N--R.sub.7 wherein R.sub.7 and R.sub.8 are hydrogen or lower alkyl, depress the activity of the central nervous system when administered to a living animal.

Abstract: Compositions and a method for combatting cholera using novel substituted quinoxalines represented by the formula ##STR1## where R is hydrogen or lower alkyl of 1 to 5 carbon atoms, e.g., methyl to pentyl, are provided. A process for preparing the compounds is also provided.

Abstract: A composition of cysteamine and a compound represented by the formula ##SPC1##Where R is hydrogen, --CHO or ##EQU1## useful for the treatment of an animal infected with a virus.

Abstract: This invention relates to 2-amino-4-[2-(1-lower alkyl-5-nitro-2-imidazolyl)vinyl]-pyrimidines and their use in the treatment of protozoal diseases and bacterial infections.