Patents Assigned to Istituto Di Ricerche Di Biologia Molecolare (IRBM)
  • Peptide inhibitors of farnesyl-protein transferase
    Patent number: 5661128
    Abstract: The present invention is directed to tetrapeptides which inhibit farnesyl-protein transferase (FPTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to a method of treating cancer with tetrapeptide inhibitors of farnesyl protein transferase, as well as pharmaceutical formulations useful for this method of treatment.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: August 26, 1997
    Assignees: Merck & Co. Inc., Istituto Di Ricerche Di Biologia Molecolare (IRBM)
    Inventors: Richardo Cortese, Jackson B. Gibbs, Antonello Pessi, Andrew Wallace