Patents Assigned to ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGE
  • Amide Derivatives as Inhibitors of Histone Deacetylase
    Publication number: 20080221157
    Abstract: The present invention relates to ketone derivatives that are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are useful for treating cellular proliferative diseases, including cancer. Further, the compounds of the present invention are useful for treating neurodegenerative diseases, schizophrenia and stroke among other diseases.
    Type: Application
    Filed: July 11, 2005
    Publication date: September 11, 2008
    Applicants: ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGE, MERCK & CO. INC.
    Inventors: Prasun K. Chakravarty, Steven L. Colletti, Raffaele Ingenito, Philip Jones, Peter T. Meinke, Ester Muraglia, Alessia Petrocchi, Michael Rowley, Rita Scarpelli, Christian Steinkuhler
  • Assay for Cytochrome P450 Isoforms 3A4 and 3A5
    Publication number: 20080145886
    Abstract: A rapid and sensitive radiometric assay for assessing the activity of cytochrome P450 (CYP) 3A4/5 and the potential of an analyte to inhibit CYP3A4/5 activity or induce CYP3A4/5 expression is described. All the steps of the assay, including incubations, product separation, and radioactivity counting are preferably performed in a multiwell format, which can be automated.
    Type: Application
    Filed: October 3, 2005
    Publication date: June 19, 2008
    Applicant: ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGE
    Inventors: Ralph Laufer, Annalise Di Marco