Abstract: The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses, in particular in the treatment of diseases or disorders associated to increased relative to physiological or desired RhoJ/Cdc42 levels of expression or function.

Abstract: The present invention relates to methods for cancer detection using nematodes or nematodes GPCR receptors.

Abstract: A determination of supramolecular organization in a substance includes target molecules and nanocarriers at least one of which is luminescent, based on a step of collecting of lifetime decay data of at least a standard substance pure or substantially pure where a known organization state of the target molecules and the nanocarriers is pure or substantially pure; and a step of comparing the standard data and test data from a test substance.

Abstract: A method and an apparatus for preparing an edge of a reel of web material wherein it is envisaged to grip any portion of an external layer of web material of a new reel, removing damaged web material forming loops of the reel, and arranging a leading edge of the new reel to be joined with a tail edge of the reel close to finishing,

Abstract: An electrically conductive adhesive composition, free of metals and metal salts, includes an adhesive polymer component selected from polyethylene-vinyl acetate, polyolefin elastomers, polyvinyl butyral, poly(acrylic acid), polyacrylates and poly(methyl methacrylate) from 5% to 40% by weight, an electrically conductive component including acetylene or carbon black nanoparticles, carbon nanotubes, and flakes or plates of graphene or graphene derivatives from 60% to 95% by weight, percentages by weight of the adhesive polymer component and electrically conductive component, the electrically conductive component consisting of acetylene or carbon black nanoparticles from 15% to 45% by weight, carbon nanotubes from 5% to 25% by weight, and flakes or plates of graphene or graphene derivatives from 35% to 70% by weight, percentages by weight of the electrically conductive component, and a solvent compatible with the adhesive polymer component from 50% to 90% by weight of the electrically conductive adhesive composit

Abstract: Spectrometer for analyzing the spectrum of a Brillouin scattered light including input means receiving the scattered light, and selecting means for selecting and separating specific multiple frequency components of the scattered light. The selecting means has at least one main input, and at least an optical detector is coupled to the selecting means for measuring the intensity of the different frequency components and reconstructing the spectrum profile of the scattered light. The selecting means include an optical integrated circuit having at least one optical ring resonator of a first type having an input waveguide for receiving the light from the input means, a closed loop waveguide having an effective refractive index neff, and an output waveguide. The selecting means further have at least a modulator element of the effective refractive index neff coupled to the closed loop waveguide of the optical ring resonator of the first type.

Abstract: An artificial wrist including a static body adapted to be bound to a support; a movable body adapted to be bound to an end effector; and a junction block defining an axis of rotation between the static body and the movable body and including a cable suitable to be moved by mutual rotation of the bodies and around the axis of rotation, and elastic member placing the cable under tensile stress and working in opposition to the movement of the cable to define a rest position in which the cable and the elastic member exerts a zero resulting torque on the bodies and, and an activation position in which they exert a non-zero resulting torque on the bodies and, bringing the bodies and back to the rest position.

Abstract: The invention relates to functional nucleic acid molecules comprising a target determinant sequence and a regulatory sequence wherein the functional nucleic acid molecule comprises one or more chemical modifications, particularly for use in methods of increasing target protein synthesis efficiency.

Abstract: An ankle prosthesis is disclosed having an actuation system so as to act as a brake, modulated by motor means, proportional to the load stressing the prosthesis. The prosthesis is advantageously capable of reducing the work necessary to lift the prosthesis while maintaining an anthropometric encumbrance.

Abstract: A determination of supramolecular organization in a substance includes target molecules and nanocarriers at least one of which is luminescent, based on a step of collecting of lifetime decay data of at least a standard substance pure or substantially pure where a known organization state of the target molecules and the nanocarriers is pure or substantially pure; and a step of comparing the standard data and test data from a test substance.

Abstract: Apparatus for transferring conductive patterns to a substrate (56), comprising a module (52) configured to transfer a pattern (63) of sinterable material (63a) to said substrate (56) and an optical module (12) to perform a sintering of the transferred pattern (63a). Said apparatus comprises one or more self-propelled pattern transferring units (52) comprising a module configured to move said self-propelled unit (14, 20) over said substrate (56) under the control of movement instructions (53b) associated to a motor (16, 21), said self-propelled unit (14, 20) comprising said module (52) configured to transfer a pattern (63a) of sinterable material (CI) to said substrate (56) obtaining a transferred pattern (63a) and comprising also said optical module (12) to perform a sintering of the transferred pattern (63a) on said substrate (56) obtaining a sintered pattern (63b, 63c).

Abstract: Cellulose-based composite material comprising an electrically conductive material dispersed in a matrix comprising at least one plant-derived protein and a polymer of aleuritic acid, said composite material being obtainable by a process comprising the steps of dissolving at least one plant-derived protein and aleuritic acid in a dissolving solution to achieve a first mixture, dispersing an electrically conductive material in said first mixture to achieve a conductive ink, distributing said conductive ink on at least one side of a cellulose substrate to achieve a coated cellulose substrate, hot-pressing said coated cellulose substrate to obtain i) impregnation of the cellulose substrate with said conductive ink and ii) polymerization of aleuritic acid.

Abstract: A hand-held device is provided for precisely positioning a needle tip at a desired target position into a non-homogeneous material, including a blood vessel. The hand-held device includes a casing hand-held by an operator, a shaft extending along a longitudinal axis and carrying the needle, the shaft mounted in the casing and coupled to the casing to move as a single piece therewith along the longitudinal axis. The hand-held device further includes a sensor unit to provide signals indicative of a physical characteristic of the material wherein the needle tip has to be inserted, and a control unit configured to determine, based on the signals received from the sensor unit, whether the needle tip has reached the target position and to operate a decoupling unit to decouple the shaft and the needle from the casing or to operate an actuating unit to actively move the shaft relative to the casing.

Abstract: A multi-layered material with low thickness is provided, having properties of thermal and electric insulation, flame retardant capacity and high mechanical strength, useful for the manufacture of personal protective equipment and more in general of work items for the protection against arc flash effects. The material provides a high grade of protection against arc flash with good flexibility and comfort for the wearer, who is thus protected without being hindered in movements.

Abstract: Body protection devices, particularly protective helmets are provided, which comprise a shell of plastic material or of fiber-reinforced plastic material, wherein the shell comprises an outer coating layer formed of a polyacrylic or polyepoxide polymeric matrix including graphene fillers. Processes for the production of body protection devices are also provided.

Abstract: A system for optical spectroscopy through a probe implanted in a tissue is provided. The system includes a light collecting probe comprising a waveguide formed by a single optical fiber and having a proximal end and a distal end, the proximal end being formed with a taper along which at least one optical window is positioned, wherein light entering at an axial section of the taper generates a specific subset of guided modes defined by the diameter of the single optical fiber at the axial section, the guided modes propagating toward the distal end of the waveguide and generating an output at the distal end of the waveguide; a demultiplexer configured to receive outputs provided by the light collecting probe and discriminate the outputs based on their modal content of origin; and a detector configured to detect the discriminated outputs.

Abstract: A thermomagnetic apparatus for electric power production, comprising: a hollow toric vessel (30) delimited by a wall (31) having an outer toric surface (31a) having a toroidal direction, wherein the toric wall (31) encloses a volume containing a ferrofluid which comprises magnetic nanoparticles dispersed or suspended in a fluid carrier; a plurality of hydraulic conduits (36-39) in thermal contact with the outer toric surface (31a); a magnetic field source (62) coupled to the outer toric surface (62) and an extraction coil (65) which comprises a plurality of turns (65?) of electrical conductor wire arranged on the outer toric surface (31a).

Abstract: There is disclosed a trans-acting functional nucleic acid molecule comprising a eukaryotic target binding sequence comprising a sequence reverse complementary to a target mRNA sequence for which protein translation is to be enhanced, and a regulatory sequence comprising an internal ribosome entry site (IRES) sequence or an internal ribosome entry site (IRES) derived sequence and enhancing translation of the target mRNA sequence, wherein the regulatory sequence is located 3? of the target binding sequence.

Abstract: The present invention refers to Amadoriase enzyme protein variants having de-glycating activity and improved thermostability compared to the wild type Amadoriase. The present invention refers also to the use of the thermostabilized Amadoriase as deglycating agent, preferably in the food industry. Moreover, the present invention refers to the use of the thermostabilized Amadoriase as diagnostic and/or therapeutic tools. Preferably, the Amadoriase enzyme protein variants of the invention can be used for determining the level of glycated haemoglobin in a biological sample and therefore for monitoring diabetes.

Abstract: The present invention relates to magnetic nanoparticles based on iron oxide having cubic shape, suitably functionalized for the release of targeting chemotherapeutic agents, i.e. selectively in the tumors being treated The invention also relates to the pharmaceutical compositions having such nanoparticles and to their use in combined oncological therapies of hyperthermia and chemotherapy, useful in particular in the treatment of ovarian tumors.