Patents Assigned to Istituto Lusofarmaco d'Italia s.p.a. - Justia Patents Search

Patents Assigned to Istituto Lusofarmaco d'Italia s.p.a.

Imidazolone derivatives with activity on central nervous system and antihypertensive activity, preparation methods thereof, and pharmaceutical compositions containing them

Patent number: 5059601

Abstract: Invention concerns 4,5-bisubstituted-2-imidazolone derivatives of formula I ##STR1## and pharmaceutically acceptable salts thereof, having high affinity in vitro for D.sub.2, 5-HT.sub.2, .sub.1 receptors and in vivo activity on central nervous system and antihypertensive activity with negligible secondary effects; methods for the preparation thereof; pharmaceutical formulations containing them.

Type: Grant

Filed: January 18, 1990

Date of Patent: October 22, 1991

Assignee: Istituto Lusofarmaco d'Italia S.p.A.

Inventors: Aldo Salimbeni, Giuseppe Cascio, Elso Manghisi
Substituted 2-phenylamino-imidazolines-(2) and pharmaceutical compositions containing them

Patent number: 4262006

Abstract: The invention provides novel substituted 2-phenylamino-imidazolines-(2) having hypotensive, bradycardizing and diuretic activities.

Type: Grant

Filed: December 6, 1979

Date of Patent: April 14, 1981

Assignee: Istituto Lusofarmaco d'Italia s.p.a.

Inventors: Elso Manghisi, Giuseppe Cascio, Giancarlo B. Fregnan, Giovanni Ferni