Patents Assigned to Istituto Nazional per Lo Studio e la Cura Dei Tumori
  • 7-Substituted camptothecin derivatives and methods for inhibiting the growth of tumor cells therewith
    Patent number: 6130227
    Abstract: 20S-Camptothecin derivatives in which the 7-position bears as a substituent --CN, --CH(CN)R.sub.4, --CH.dbd.C(CN)R.sub.4, --C(.dbd.NOH)NH.sub.2, --C(.dbd.NH)NH.sub.2, --CH.dbd.C(NO.sub.2)R.sub.4, --CH(CN)R.sub.5, --CH(CH.sub.2 NO.sub.2)R.sub.5, tetrazol-5-yl, 4,5-dihydrooxazol-2-yl, or 1,2,4-oxadiazolin-3-yl-5-one. These compounds are active as topoisomerase I inhibitors, and can be used as antitumor drugs.
    Type: Grant
    Filed: August 20, 1998
    Date of Patent: October 10, 2000
    Assignee: Istituto Nazional per Lo Studio e la Cura Dei Tumori
    Inventors: Lucio Merlini, Sergio Penco, Franco Zunino