Patents Assigned to ISTO Technologies, Inc.
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Patent number: 11173246Abstract: The present disclosure provides devices, kits and methods for preparing injections with cells and carrier components for delivery to a target area in the body. The disclosed devices, kits, and methods provide preparation and monitoring of injections.Type: GrantFiled: January 22, 2019Date of Patent: November 16, 2021Assignee: Isto Technologies, Inc.Inventors: Michael Maloney, Torrey Munger, Gary Gage, H. Davis Adkisson, IV
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Patent number: 10729814Abstract: The present disclosure relates to cartilage repair compositions and methods for modifying the proteoglycan content of the compositions. Specifically, the methods relate to serum free, collagen free neocartilage made from chondrocytes that can be used for implants. Proteoglycans, such as aggrecan and sulfated glycosaminoglycan are used and the content modified using temperature changes.Type: GrantFiled: July 30, 2015Date of Patent: August 4, 2020Assignee: Isto Technologies, Inc.Inventors: Neil Kizer, Nicole M. Bergmann, Gary Gage, Huston Davis Adkisson, Michael Maloney
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Patent number: 9937057Abstract: The present disclosure provides a delivery device for delivering a tissue repair composition in paste form, such as a bone graft extender and substitute in paste form, for use in surgical procedures including minimally invasive spine (fusion) surgery, open spine surgery and other orthopedic procedures.Type: GrantFiled: September 24, 2013Date of Patent: April 10, 2018Assignee: ISTO Technologies, Inc.Inventor: Gary B. Gage
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Publication number: 20140308251Abstract: The present application discloses compositions, methods and devices for treatment of a degenerative intervertebral disc. A composition can comprise chondrocytes expressing type II collagen. These chondrocytes can be obtained from human cadavers up to about two weeks following death, and can be grown in vitro. The compositions can further comprise one or more biocompatible molecules. Treatment of a degenerative disc can comprise injecting or implanting a composition comprising the chondrocytes into a degenerative disc through an aperture or incision. If the aperture or incision is closed with a suture or a glue after introduction of the chondrocytes, the closure can withstand over 400 N of compression force.Type: ApplicationFiled: March 18, 2014Publication date: October 16, 2014Applicant: ISTO TECHNOLOGIES, INC.Inventors: Mitchell S. Seyedin, H. Davis Adkisson
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Publication number: 20140142718Abstract: A synthetic, flexible tissue matrix and methods for repairing hyaline cartilage defects in a joint using the flexible tissue matrix are described. The flexible tissue matrix includes a high molecular weight polycaprolactone polymer entangled with a polysaccharide such as hyaluronic acid. In the methods, autologous bone mesenchymal stem cells are introduced to a joint by a microfracturing technique, and a membrane made of the flexible matrix is applied to the joint. Cartilage which forms in the joint is hyaline cartilage rather than fibrocartilage.Type: ApplicationFiled: March 15, 2013Publication date: May 22, 2014Applicant: ISTO TECHNOLOGIES, INC.Inventors: Mitchell S. Seyedin, Anthony J. Ward, Matthew Matava
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Publication number: 20140088712Abstract: The present disclosure provides a delivery device for delivering a tissue repair composition in paste form, such as a bone graft extender and substitute in paste form, for use in surgical procedures including minimally invasive spine (fusion) surgery, open spine surgery and other orthopedic procedures.Type: ApplicationFiled: September 24, 2013Publication date: March 27, 2014Applicant: ISTO Technologies, Inc.Inventor: Gary B. Gage
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Patent number: 8580289Abstract: The present application discloses matrix compositions to support the repair of tissue defects such as an injury to tendon tissue, ligament tissue, vascular tissue, dermal tissue, or muscle tissue. A matrix described herein comprises a polyester polymer entangled with a polysaccharide polymer. Also disclosed are methods of preparing a matrix, and methods of using a matrix in the repair of tissue. In certain configurations, a matrix can comprise a polyester cross-linked with a polysaccharide, which can be an oxidized polysaccharide. In some configurations, a matrix can further comprise one or more additional components, such as a growth factor or an anti-infective agent. In some configurations, a matrix can be a viscous fluid or a paste, while in other configurations a matrix can be comprised by a solid such as a plug, a granule or a membrane.Type: GrantFiled: June 23, 2011Date of Patent: November 12, 2013Assignee: ISTO Technologies Inc.Inventors: Mitchell S. Seyedin, Gary B. Gage
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Patent number: 8512730Abstract: The present application discloses matrix compositions to support the repair of tissue defects such as an injury to tendon tissue, ligament tissue, vascular tissue, dermal tissue, or muscle tissue. A matrix described herein comprises a polyester polymer entangled with a polysaccharide polymer. Also disclosed are methods of preparing a matrix, and methods of using a matrix in the repair of tissue. In certain configurations, a matrix can comprise a polyester cross-linked with a polysaccharide, which can be an oxidized polysaccharide. In some configurations, a matrix can further comprise one or more additional components, such as a growth factor or an anti-infective agent. In some configurations, a matrix can be a viscous fluid or a paste, while in other configurations a matrix can be comprised by a solid such as a plug, a granule or a membrane.Type: GrantFiled: June 7, 2006Date of Patent: August 20, 2013Assignee: Isto Technologies, Inc.Inventors: Mitchell S. Seyedin, Gary Gage
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Patent number: 8444968Abstract: The present application discloses methods for repairing hyaline cartilage defects. The methods comprise a combination of introducing autologous bone mesenchymal stem cells to a joint, and applying to the joint a membrane comprising a polyester entangled with a polysaccharide. In some aspects, the bone mesenchymal stem cells are mesenchymal stem cells originating in bone underlying the joint. In these aspects, contact between the joint and the mesenchymal stem cells can be effected by introducing apertures through the bone using standard surgical techniques such as microfracture, abrasion, or drilling. Cartilage which forms in response to application of these methods is hyaline cartilage rather than fibrocartilage.Type: GrantFiled: December 7, 2006Date of Patent: May 21, 2013Assignee: Isto Technologies, Inc.Inventors: Mitchell S. Seyedin, Matthew Matava
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Patent number: 8192759Abstract: The present application discloses matrix compositions to support the repair of tissue defects such as an osteochondral injury. A matrix described herein comprises a polyester polymer entangled with a polysaccharide polymer. Also disclosed are methods of preparing a matrix, and methods of using a matrix in the repair of tissue. In certain configurations, a matrix can comprise a polyester cross-linked with a polysaccharide, which can be an oxidized polysaccharide. In some configurations, a matrix can further comprise one or more additional components, such as a growth factor.Type: GrantFiled: July 11, 2005Date of Patent: June 5, 2012Assignee: ISTO Technologies, Inc.Inventors: Mitchell S. Seyedin, Robert Spiro
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Publication number: 20120107384Abstract: Implants for repairing tissue defects, such as cartilage tissue defects, and methods of their preparation and use are disclosed. A mold of a tissue defect is prepared by pressing upon the defect a substrate having shape memory, such as aluminum foil. The mold, which has contours substantially conforming to those of the defect, is removed from the defect, and tissue particles are added to the mold ex vivo. A biological carrier such as biocompatible glue is also added to the mold. The combination of tissue particles and the biological carrier thereby form an implant, which retains its shape after separation from the mold. The implant can be transferred to the tissue defect, with contours of the mold matching corresponding contours of the defect.Type: ApplicationFiled: December 15, 2011Publication date: May 3, 2012Applicants: ZIMMER, INC., ISTO TECHNOLOGIES, INC.Inventors: Jian Q. Yao, Ben Walthall, Jizong Gao, Victor Zaporojan
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Publication number: 20120087948Abstract: The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions.Type: ApplicationFiled: December 22, 2010Publication date: April 12, 2012Applicant: ISTO TECHNOLOGIES, INC.Inventors: Neil Kizer, Robert Spiro, Jian Yao, Cheryl Renee Blanchard
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Publication number: 20120009270Abstract: The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions.Type: ApplicationFiled: December 22, 2010Publication date: January 12, 2012Applicant: ISTO TECHNOLOGIES, INC.Inventors: Neil Kizer, Robert Spiro, Jian Yao, Cheryl Renee Blanchard
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Publication number: 20120009224Abstract: The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions.Type: ApplicationFiled: December 22, 2010Publication date: January 12, 2012Applicant: ISTO TECHNOLOGIES, INC.Inventors: Neil Kizer, Robert Spiro, Jian Yao, Cheryl Renee Blanchard
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Publication number: 20110256095Abstract: The present application discloses matrix compositions to support the repair of tissue defects such as an injury to tendon tissue, ligament tissue, vascular tissue, dermal tissue, or muscle tissue. A matrix described herein comprises a polyester polymer entangled with a polysaccharide polymer. Also disclosed are methods of preparing a matrix, and methods of using a matrix in the repair of tissue. In certain configurations, a matrix can comprise a polyester cross-linked with a polysaccharide, which can be an oxidized polysaccharide. In some configurations, a matrix can further comprise one or more additional components, such as a growth factor or an anti-infective agent. In some configurations, a matrix can be a viscous fluid or a paste, while in other configurations a matrix can be comprised by a solid such as a plug, a granule or a membrane.Type: ApplicationFiled: June 23, 2011Publication date: October 20, 2011Applicant: ISTO TECHNOLOGIES, INC.Inventors: Mitchell S. Seyedin, Gary Gage
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Patent number: 8017394Abstract: The present invention provides a method for expanding a population of chondrocytes that maintains chondrocyte phenotype during the expansion by culturing the population in a defined serum-free expansion medium containing one or more cytokines and under low attachment conditions. The method further solves diffusion problems during the subsequent stage of extracellular matrix production by use of a perforated polycarbonate substrate that results in a randomly organized cultured neocartilage tissue. Chondrocytes expanded and cultured in this manner can be used in various medical applications to repair cartilaginous tissues that have been injured by trauma or disease.Type: GrantFiled: September 21, 2007Date of Patent: September 13, 2011Assignee: ISTO Technologies, Inc.Inventors: Huston Davis Adkisson, IV, Curt L Milliman, Neil Kizer
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Publication number: 20100322994Abstract: The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions.Type: ApplicationFiled: August 23, 2010Publication date: December 23, 2010Applicant: ISTO TECHNOLOGIES, INC.Inventors: Neil Kizer, Robert Spiro, Jian Yao, Cheryl Renee Blanchard
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Patent number: 7824711Abstract: The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions.Type: GrantFiled: December 13, 2004Date of Patent: November 2, 2010Assignees: Isto Technologies, Inc., Zimmer, Inc.Inventors: Neil Kizer, Robert Spiro, Jian Q. Yao, Cheryl Renee Blanchard
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Publication number: 20090143867Abstract: Implants comprising cartilage and trabecular metal, and methods of making the implants are disclosed. Further disclosed are therapeutic uses of the implants, which include methods of treatment or repair of an chondral or osteochondral defect, such as a chondral or osteochondral injury, lesion or disease. An implant comprises cartilage or chondrocytes and a subchondral base comprising trabecular metal. An implant can comprise a geometric shape such as a cylinder or an anatomical shape such as a condyle, and can be used in conjunction with a positioning structure.Type: ApplicationFiled: August 28, 2006Publication date: June 4, 2009Applicant: ISTO Technologies, Inc.Inventors: Gary Gage, H. Davis Adkisson, IV, Cheryl R. Blanchard
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Publication number: 20090012629Abstract: Implants for repairing tissue defects, such as cartilage tissue defects, and methods of their preparation and use are disclosed. A mold of a tissue defect is prepared by pressing upon the defect a substrate having shape memory, such as aluminum foil. The mold, which has contours substantially conforming to those of the defect, is removed from the defect, and tissue particles are added to the mold ex vivo. A biological carrier such as biocompatible glue is also added to the mold. The combination of tissue particles and the biological carrier thereby form an implant, which retains its shape after separation from the mold. The implant can be transferred to the tissue defect, with contours of the mold matching corresponding contours of the defect.Type: ApplicationFiled: April 11, 2008Publication date: January 8, 2009Applicants: ISTO TECHNOLOGIES, INC., ZIMMER, INC.Inventors: Jian Q. Yao, Ben Walthall, Jizong Gao, Victor Zaporojan