Patents Assigned to Italfarmaco Sud S.p.A.
  • Patent number: 6297387
    Abstract: Chiral diphosphines constituted by an aromatic pentatomic biheterocyclic system, suitable to act as chiral ligands, complexes between said diphosophines and transition metals, and their utilization as chiral catalysts in stereocontrolled reactions, such as diastereo- and enantioselective reduction reactions. Process for the preparation of said chiral diphosophines and process for the preparation of said complexes and for their utilization as chiral catalysts in stereocontrolled reaction.
    Type: Grant
    Filed: April 5, 1999
    Date of Patent: October 2, 2001
    Assignee: Italfarmaco Sud S.p.A.
    Inventors: Patrizia Antognazza, Tiziana Benincori, Elisabetta Brenna, Edoardo Cesarotti, Francesco Sannicolo, Licia Trimarco
  • Patent number: 6133191
    Abstract: Chiral diphosphines constituted by an aromatic pentatomic biheterocyclic system, suitable to act as chiral ligands, complexes between said diphosophines and transition metals, and their utilization as chiral catalysts in stereocontrolled reactions, such as diastereo- and enantioselective reduction reactions. Process for the preparation of said chiral diphosophines and process for the preparation of said complexes and for their utilization as chiral catalysts in stereocontrolled reactions.
    Type: Grant
    Filed: April 5, 1999
    Date of Patent: October 17, 2000
    Assignee: Italfarmaco Sud S.p.A.
    Inventors: Patrizia Antognazza, Tiziana Benincori, Elisabetta Brenna, Edoardo Cesarotti, Francesco Sannicolo', Licia Trimarco
  • Patent number: 6077958
    Abstract: Chiral diphosphines are constituted by an aromatic pentatomic biheterocyclic system, suitable to act as chiral ligands and complexes between the diphosphines and transition metals. They may be utilized as chiral catalysts in stereocontrolled reactions, such as diastereo- and enantioselective reduction reactions. Process is for the preparation of these chiral diphosphines; and process is for the preparation of these complexes and for their utilization as chiral catalysts in stereocontrolled reactions.
    Type: Grant
    Filed: April 27, 1999
    Date of Patent: June 20, 2000
    Assignee: Italfarmaco Sud S.p.A.
    Inventors: Patrizia Antognazza, Tiziana Benincori, Elisabetta Brenna, Edoardo Cesarotti, Francesco Sannicolo', Licia Trimarco
  • Patent number: 5907045
    Abstract: Chiral diphosphines constituted by an aromatic pentatomic biheterocyclic system, suitable to act as chiral ligands, complexes between said diphosophines and transition metals, and their utilization as chiral catalysts in sterocontrolled reactions, such as diastereo- and enantioselective reduction reactions. Process for the preparation of said chiral diphosophines and process for the preparation of said complexes and for their utilization as chiral catalysts in sterocontrolled reactions.
    Type: Grant
    Filed: December 23, 1996
    Date of Patent: May 25, 1999
    Assignee: Italfarmaco Sud S.p.A.
    Inventors: Patrizia Antognazza, Tiziana Benincori, Elisabetta Brenna, Edoardo Cesarotti, Francesco Sannicolo', Licia Trimarco
  • Patent number: 5700668
    Abstract: The invention relates to a process for the preparation of phosphatidylserines by reacting racemic or enantiomerically pure serine, preferably (L)-serine, with natural phosphatides, such as soybean or egg lecithin, or with synthetic phosphatides, in the presence of a phospholipase D, having transphosphatidylating activity, in an aqueous/organic diphasic system.
    Type: Grant
    Filed: December 8, 1995
    Date of Patent: December 23, 1997
    Assignee: Italfarmaco Sud S.p.A.
    Inventors: Lorenzo De Ferra, Pietro Massardo, Oreste Piccolo, Stefano Servi
  • Patent number: 5433833
    Abstract: A process for fractionating deacylated glycerophospholipids of the formula (I): ##STR1## wherein R is a negative charge; a hydrogen atom; a CH.sub.2 CH.sub.2 NR.sup.1 R.sup.2 residue wherein R.sup.1 and R.sup.2, which are the same or different, are H or C.sub.1 -C.sub.4 alkyl; a CH.sub.2 CH.sub.2 N.sup.+ (CH.sub.3).sub.3 residue; a CH.sub.2 CH(NH.sub.2)COOH residue or a residue of the formula: ##STR2## and X is OH or 0.sup.-, is described. The process involves subjecting an aqueous or hydroalcoholic mixture of two or more of the deacylated glycerophospholipids to electrodialysis in an electrolytic cell comprising a number of compartments. The compartments are separated by cation-exchange membranes, anion-exchange membranes or both cation-exchange and anion-exchange membranes, at a pH effective to differentiate the deacylated glycerophospholipids.
    Type: Grant
    Filed: May 10, 1994
    Date of Patent: July 18, 1995
    Assignee: Italfarmaco Sud S.p.A.
    Inventors: Lorenzo de Ferra, Sandra Rondinini, Patrizia R. Mussini, Fausto Bonifacio, Pietro Massardo, Oreste Piccolo