Abstract: Disclosed is a fragmentation unit including: —a frame in which there extends a region for receiving a bag, the contents of which is to be fragmented, the region being delimited by the ground and by four virtual planar vertical faces, and divided into a front area and a rear area of equal dimensions by a vertical plane, —at least two pressure plates that are able to move towards each other and vertically, each having a front edge and a vertical planar pressing face, having a rear edge, the rear edge being situated behind a plane containing the virtual planar rear face, and the front edge being tangential to a vertical plane parallel to the plane and dividing the front area of the region into two sub-areas. Also disclosed is a fragmentation method.

Abstract: The present invention related to the proline rich transmembrane protein 2 (PRRT2) gene, and the identification of mutations and variations in PRRT2 that give rise to seizure and movement disorders. Accordingly, the present invention provides methods for the diagnosis or prognosis of such disorders by identifying alterations in the PRRT2 gene. Identification of alterations in the PRRT2 gene also enables the identification of subjects with an increased likelihood of having an offspring predisposed to such disorders. The present invention also provides an isolated nucleic acid molecule comprising an alteration in the PRRT2 gene, wherein said alteration produces a seizure and/or movement disorder phenotype. Also provided is an isolated PRRT2 polypeptide that comprises an alteration which produces a seizure and/or movement disorder phenotype.

Abstract: The present invention relates to the proline rich transmembrane protein 2 (PRRT2) gene, and the identification of mutations and variations in PRRT2 that give rise to seizure and movement disorders. Accordingly, the present invention provides methods for the diagnosis or prognosis of such disorders by identifying alterations in the PRRT2 gene. Identification of alterations in the PRRT2 gene also enables the identification of subjects with an increased likelihood of having an offspring predisposed to such disorders. The present invention also provides an isolated nucleic acid molecule comprising an alteration in the PRRT2 gene, wherein said alteration produces a seizure and/or movement disorder phenotype. Also provided is an isolated PRRT2 polypeptide that comprises an alteration which produces a seizure and/or movement disorder phenotype.

Abstract: The present invention relates to the proline rich transmembrane protein 2 (PRRT2) gene, and the identification of mutations and variations in PRRT2 that give rise to seizure and movement disorders. Accordingly, the present invention provides methods for the diagnosis or prognosis of such disorders by identifying alterations in the PRRT2 gene. Identification of alterations in the PRRT2 gene also enables the identification of subjects with an increased likelihood of having an offspring predisposed to such disorders. The present invention also provides an isolated nucleic acid molecule comprising an alteration in the PRRT2 gene, wherein said alteration produces a seizure and/or movement disorder phenotype. Also provided is an isolated PRRT2 polypeptide that comprises an alteration which produces a seizure and/or movement disorder phenotype.

Abstract: The present invention relates to the proline rich transmembrane protein 2 (PRRT2) gene, and the identification of mutations and variations in PRRT2 that give rise to seizure and movement disorders. Accordingly, the present invention provides methods for the diagnosis or prognosis of such disorders by identifying alterations in the PRRT2 gene. Identification of alterations in the PRRT2 gene also enables the identification of subjects with an increased likelihood of having an offspring predisposed to such disorders. The present invention also provides an isolated nucleic acid molecule comprising an alteration in the PRRT2 gene, wherein said alteration produces a seizure and/or movement disorder phenotype. Also provided is an isolated PRRT2 polypeptide that comprises an alteration which produces a seizure and/or movement disorder phenotype.

Abstract: A method for treating or preventing a disease, condition or state in a subject in need thereof by administering to the subject an effective amount of the (?)-enantiomer of perhexyline or a pharmaceutically acceptable salt, prodrug or derivative thereof, substantially free of the (+)-enantiomer, or pharmaceutical composition containing same. The disease, condition or state may be associated with altered tissue energetics, impaired tissue energetics, altered cardiac tissue energetics, impaired cardiac tissue energetics, altered hepatic tissue energetics, impaired hepatic tissue energetics, and diabetes.

Abstract: A compound of formula (I) or a pharmaceutically acceptable salt or solvate or physiologically hydrolysable, solubilising or immobilisable derivative thereof; wherein: any one or two of X.

Abstract: A rotary drum scanner comprises a rotatably mounted hub, a drum detachably mounted to the hub and an interlock mechanism which locks the hub against rotation until the drum is locked to the hub.

Abstract: A compact rotary drum colour separation scanner includes a drum which is rotatably mounted about an upwardly extending axis which is preferably slightly inclined to the vertical. A part of the carriage carrying either a light source or reading head travels into the drum through the hub upon which the drum is mounted.

Abstract: A method and apparatus for color separation scanning wherein a workpiece is movably supported and scanned by a linear detector. At least one color filter is interposed in the optical path between the workpiece and the linear detector and multiple scans are taken of a linear portion of the workpiece. The data obtained from multiple scans are averaged and stored in memory. A second memory may be provided to accept data input during a scan of a subsequent portion of the workpiece while the data in the first memory is output to a print device.

Abstract: An optical scanner is provided wherein each waveband, i.e. blue, green and red, is detected during successive revolutions of an analyzing drum. A variable scanning aperture disc selectively transmits a different image portion during each waveband scan so that the image portion detected during each waveband scan is transversely displaced along the axis of the analyzing drum. The transverse distance of optical image portion displacement corresponds to and corrects for the transverse distance travelled by the optical scanning head during one revolution of the analyzing drum. Magnification optics are also provided for, inter alia, adjusting the transverse displacement of the image portions.

Abstract: A system for controlling an image printer including a scanning LED array is provided. An image printer control unit receives page profile and raster image data and converts the raster image data into parallel image data corresponding to the configuration of the LED array. Advantageously, the image printer control unit optimizes the number of lines of information printed during a scan to reduce splitting of characters between scans and coordinates printhead and photosensitive medium position. Interlaced scanning for high resolution is also provided. In an alternative embodiment image data is received in parallel vertical slices and bands for which no exposure is to be made are skipped.

Abstract: A deformable mirror is disclosed having replaceable, electrically operable actuators for deforming the mirror's reflecting surface. A flexible retraction membrane is disposed between the actuators and the reflecting surface and the mirror's facesheet is bonded to the retraction membrane. The membrane provides constant contact between the facesheet and the mirror's actuators and provides a deflection load to mechanically drive the facesheet downward against the operation of the actuators, thus providing a mechanical force to deflect the mirror's reflecting surface when electrical signals are selectively removed from one or more of the mirror's actuators. The membrane contains a gradient stiffness in the vicinity of each actuator to tailor the deformation profile, to maintain circular symmetry and to minimize the curve fitting error in the vicinity of each actuator.

Abstract: A dot generator system is provided wherein an LED microchip array having staggered rows of LED's imaged onto the surface of a rotating exposure drum is controlled to create a multiple exposure beam microdot image on the drum surface in a microdot line by microdot line and scanline by scanline exposure scan. Picture values are compared to microdot density values recalled from a dot density profile array using address values incremented with microdot, flyback and scanline increment values in order to produce exposure data bits indicating whether each active LED on the array is to be turned on. Exposure data bits are accumulated into an exposure data word equal in length to the number of active LED's on the LED array and stagger compensation time delays are applied to exposure bits corresponding to the second and subsequent staggered LED rows to create a timed microdot line exposure on the drum surface.

Abstract: A color scanner is provided having a commonly mounted and driven original scanning table and LED dot generator exposure source. Scanning is accomplished by illuminating a strip of the original artwork with high intensity fluorescent light and detecting the illuminated strip through a linear scanning aperture, lens and color filter wheel using a charge coupled device ("CCD") linear detector. Original artwork is held by vacuum against the flat original artwork receiving surface and photosensitive material is automatically loaded and held by vacuum onto the surface of a rotating exposure drum mounted parallel to the direction of travel of the LED dot generator exposure source, and the exposed halftone film is automatically removed from the drum surface and loaded into a transfer cartridge. Advantageously, multiple linear scans may be averaged in order to reduce color fringe effects.

Abstract: A transport belt for an automatic camera vacuum feed and hold down system is provided. The movable, flexible opaque transport belt has a substantially uniform bottom surface facing the exposure platen and a top surface provided with at least one transverse resilient belt flexing member. The belt flexing member is preferably a curved plastic member having memory which assumes a first, curved position to create at least one air channel beneath the belt. The air channels reduce the length of time required to evacuate air beneath the belt. During vacuum hold down for exposure, the resilient belt flexing member assumes a second position, substantially parallel to the platen and the air channels are eliminated, such that the bottom belt surface presents a substantially flat uniform background surface during exposure.

Abstract: A cassette for containing and dispensing a roll of photosensitive material comprising a one-piece generally rectangular cassette body with at least one trihedral corner formed from a sheet of inexpensive material, and providing an orifice therein, a seal along the orifice, molded rectangular cassette end covers disposed at each end of the cassette body and adapted to connect to the ends of the cassette body. The cassette end covers are also adapted to support the roll of photosensitive material within the cassette and to extend beyond the cassette body on the trihedral corners to provide "feet" for the cassette.

Abstract: A non-contact LED-array image printer is provided having a scanning print head driven by a zero backlash threaded lead screw. The LED array is mounted on a substrate bearing an interface control circuit which receives video data through a ribbon cable, and the LED array is imaged by a lens onto an exposure plane on a platen parallel to the direction of scan. Means are provided for conveniently adjusting object and image distances relative to the image plane. The photosensitive medium is driven in registration in forward and reverse directions biased against the exposure platen defining the image plane. A gear, clutch and brake mechanism is provided to ensure that the photosensitive medium remains in taut registration across the exposure platen.

Abstract: An automatic vacuum feed and hold down system is provided having a transport belt with vacuum grippers, a peripheral vacuum channel surrounding the platen, and a lead edge blow apparatus. In the preferred embodiment the transport belt consists of polyester fabric selectively coated with plastisol sealant to define a window area similarly shaped but smaller than the platen and suction grippers within the window area. In the preferred mode of operation a lifting apparatus raises the belt away from the exposed photosensitive sheet on the platen and the natural curl of the sheet, together with the lead edge blow, cause the sheet to release from the platen. The lifting apparatus then lowers the belt and suction is reapplied to the grippers, whereafter the belt and sheet are raised and advanced to deliver the exposed photosensitive sheet for processing.