Patents Assigned to Ith Immune Therapy Holdings AB
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Patent number: 8932855Abstract: A method of treating cancer in a patient comprises immortalizing B cells collected from the patient by infection with Epstein Barr virus, transforming the cells to a latent stage, culturing the cells in the presence of a cancer antigen, harvesting exosomes released from the cells, administering the exosomes to the patient. Alternatively the harvested exosomes are loaded with cancer antigen.Type: GrantFiled: July 2, 2010Date of Patent: January 13, 2015Assignee: ITH Immune Therapy Holdings ABInventor: Susanne Gabrielsson
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Patent number: 8877177Abstract: An apheresis column loaded with a solid support comprises one or more chemokines, in particular biotinylated chemokines, immobilized directly or indirectly on the support, in particular on a support carrying streptavidin. Also disclosed are uses of the column and the support and a method of depleting cells, in particular leukocytes, from the peripheral blood of a person suffering from an inflammatory condition such as Inflammatory Bowel Disease (IBD).Type: GrantFiled: September 10, 2009Date of Patent: November 4, 2014Assignee: ITH Immune Therapy Holdings ABInventors: Ola Winqvist, Graham Cotton
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Patent number: 8852581Abstract: A method of treating inflammatory bowel disease (IBD) comprises collecting regulatory T cells in an activated or non-activated state from a patient's sentinel lymph nodes draining bowel segments with or without IBD, optionally activating the cells by contacting them with a cytokine and an antigen extract obtained from an inflamed bowel segment, expanding the T cells in vitro, and re-infusing the expanded T cell to the patient. Also disclosed are methods for obtaining sentinel nodes, for expanding T cells, for re-establishing the TH1/TH2 balance in the patient suffering from Crohn's disease, and corresponding uses of the expanded T cells, the cytokine and of antigen extract, as well as of correspondingly activated and expanded T cells.Type: GrantFiled: August 22, 2006Date of Patent: October 7, 2014Assignee: ITH Immune Therapy Holdings ABInventors: Ola Winqvist, Magnus Thorn
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Patent number: 8449489Abstract: A method of treating inflammatory bowel disease (IBD) comprises providing an intestinal biopsy sample obtained from inflamed tissue of a patient; mechanically treating the sample to obtain a cell suspension; identifying cell surface markers of activated leukocytes selected from T lymphocytes, neutrophil granulocytes, and eosinophil granulocytes in the suspension; raising antibodies against one of more of the activated cells and immobilizing them on a support; providing a column loaded with the support; diverting a portion of the patient's peripheral blood to make it pass through the column before re-infusing it to the patient to make the activated leukocytes couple with antibodies on the support, thereby eliminating them from the blood stream. Also disclosed are corresponding columns and supports, and their use in the method.Type: GrantFiled: May 14, 2007Date of Patent: May 28, 2013Assignee: ITH Immune Therapy Holdings ABInventors: Magnus Thorn, Ola Winqvist
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Publication number: 20110230396Abstract: A medicament to prevent or cure fungal infections of the skin or body openings in an immunologically compromised person or animal can comprise Cystatin S, Cystatin SA, Cystatin SN, or similar agents.Type: ApplicationFiled: August 20, 2009Publication date: September 22, 2011Applicant: ITH Immune Therapy Holdings ABInventor: Ola Winqvist
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Publication number: 20110224645Abstract: An apheresis column loaded with a solid support comprises one or more chemokines, in particular biotinylated chemokines, immobilized directly or indirectly on the support, in particular on a support carrying streptavidin. Also disclosed are uses of the column and the support and a method of depleting cells, in particular leukocytes, from the peripheral blood of a person suffering from an inflammatory condition such as Inflammatory Bowel Disease (IBD).Type: ApplicationFiled: September 10, 2009Publication date: September 15, 2011Applicant: ITH IMMUNE THERAPY HOLDINGS ABInventors: Ola Winqvist, Graham Cotton
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Publication number: 20090311228Abstract: A method of treating inflammatory bowel disease (IBD) comprises collecting regulatory T cells in an activated or non-activated state from a patient's sentinel lymph nodes draining bowel segments with or without IBD, optionally activating the cells by contacting them with a cytokine and an antigen extract obtained from an inflamed bowel segment, expanding the T cells in vitro, and re-infusing the expanded T cell to the patient. Also disclosed are methods for obtaining sentinel nodes, for expanding T cells, for re-establishing the TH1/TH2 balance in the patient suffering from Crohn's disease, and corresponding uses of the expanded T cells, the cytokine and of antigen extract, as well as of correspondingly activated and expanded T cells.Type: ApplicationFiled: August 22, 2006Publication date: December 17, 2009Applicant: Ith Immune Therapy Holdings ABInventors: Ola Winqvist, Magnus Thorn