Abstract: A reusable core biopsy device having a disposable needle assembly to trap and a reusable drive assembly to selectively drive the disposable needle assembly. The disposable needle assembly includes a contamination collection member defining a fluidically-sealed contamination collection chamber to receive and collect contamination during the extraction of the organic tissue sample. The reusable drive assembly includes a locking mechanism to maintain reusable drive assembly in a locked state. An activation member is to place the reusable drive assembly in an unlocked state, to thereby drive, in sequence, the inner needle member and the outer cannula member forward to extract the organic tissue sample.