Patents Assigned to ITI Life Sciences
  • Transgenic mice for assessing drug metabolism and toxicity
    Patent number: 8212105
    Abstract: The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in vivo in humans.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: July 3, 2012
    Assignee: ITI Life Sciences
    Inventors: Charles Roland Wolf, Nico Scheer, Nicole Faust
  • TRANSGENIC ANIMALS FOR ASSESSING DRUG METABOLISM AND TOXICITY
    Publication number: 20100235928
    Abstract: The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in vivo in humans.
    Type: Application
    Filed: May 26, 2010
    Publication date: September 16, 2010
    Applicant: ITI LIFE SCIENCES
    Inventors: Charles Roland Wolf, Nico Scheer, Nicole Faust
  • Transgenic animals for assessing drug metabolism and toxicity
    Patent number: 7759541
    Abstract: The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in vivo in humans.
    Type: Grant
    Filed: June 4, 2007
    Date of Patent: July 20, 2010
    Assignee: ITI Life Sciences
    Inventors: Charles Roland Wolf, Nico Scheer, Nicole Faust