Patents Assigned to ITM Isotopen Technologien Munchen AG
  • Publication number: 20210350946
    Abstract: A method for recovering a parent radionuclide from a radionuclide generator is disclosed where the parent radionuclide is adsorbed to a stationary phase. The method contains a series of elutions. At least one elution is with an alcohol. At least one elution with water. At least one elution is with a mineral acid other than hydrochloric acid that is paused to soak the stationary phase with the mineral acid.
    Type: Application
    Filed: October 2, 2020
    Publication date: November 11, 2021
    Applicants: ITM Isotopen Technologien München AG, TRIUMF, A JOINT VENTURE OF THE GOVENORS OF THE UNIVERSITY OF ALBERTA, THE UNIVERSITY OF BRITISH COLU
    Inventors: Stefan K. ZEISLER, Ellard PORTMAN
  • Patent number: 10943709
    Abstract: A 68Ge/68Ga generator for a continuous production of a 68Ga daughter nuclide, wherein the 68Ge parent nuclide thereof is specifically adsorbed to an inorganic support material and wherein said 68Ge parent nuclide continuously decays to 68Ga by electron capture at a half-life of 270.82 d, wherein the inorganic support material is at least one oxide of a metal being selected from the group consisting of: Vanadium, Niobium and Tantalum. The use of at least one oxide of a metal being selected from the group consisting of: Vanadium, Niobium and Tantalum as an inorganic support material for the manufacture of a 68Ge/68Ga generator for pharmaceutical purposes. With the inorganic support material of the present invention, it is possible to load 68Ge/68Ga generators with up to 8000 MBq of 68Ge (corresponding to 80 ?g Germanium).
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: March 9, 2021
    Assignee: ITM Isotopen Technologien München AG
    Inventors: Jussi Jernström, Konstantin Zhernosekov, Yury Totskiy, Mark Harfensteller, Marian Meckel
  • Patent number: 9816156
    Abstract: The present invention relates to a column chromatographic method of manufacturing non-carrier-added high-purity 177Lu compounds for medicinal purposes. In the method in accordance with the invention a cation exchanger and a suitable chelating agent are used. With the method in accordance with the invention it is possible for the first time to provide non-carrier-added high-purity 177Lu compounds in milligram amounts for pharmaceutical-medicinal purposes from 176Yb compounds irradiated with thermal neutrons, the radionuclides 177Lu and 176Yb being present in an approximate mass ratio of 1:102 to 1:1010 for purification.
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: November 14, 2017
    Assignee: ITM Isotopen Technologien München AG
    Inventors: Sebastian Marx, Mark Harfensteller, Konstantin Zhernosekov, Tuomo Nikula
  • Patent number: 9802969
    Abstract: Molecule for attaching a radioactive parent nuclide to a support, comprising at least one functional group for attaching the radioactive parent nuclide; and a molecular moiety suitable for establishing a nonpolar bond to the support.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: October 31, 2017
    Assignee: ITM Isotopen Technologien Munchen AG
    Inventors: Konstantin Zhernosekov, Tuomo Nikula
  • Patent number: 9142328
    Abstract: Molecule for attaching a radioactive parent nuclide to a support, comprising at least one functional group for attaching the radioactive parent nuclide; and a molecular moiety suitable for establishing a nonpolar bond to the support.
    Type: Grant
    Filed: February 4, 2010
    Date of Patent: September 22, 2015
    Assignee: ITM ISOTOPEN TECHNOLOGIEN MÜNCHEN AG
    Inventors: Konstantin Zhernosekov, Tuomo Nikula
  • Patent number: 8937166
    Abstract: The present invention relates to a 68Ga generator, wherein the 68Ge parent nuclide thereof is attached specifically to a support through a triethoxyphenyl group and continuously disintegrates to 68Ga, the triethoxyphenyl group being covalently bound to a support material through a linker.
    Type: Grant
    Filed: June 27, 2013
    Date of Patent: January 20, 2015
    Assignee: ITM Isotopen Technologien Munchen AG
    Inventors: Konstantin Zhernosekov, Tuomo Nikula
  • Publication number: 20140294700
    Abstract: The present invention relates to a column chromatographic method of manufacturing non-carrier-added high-purity 177Lu compounds for medicinal purposes. In the method in accordance with the invention a cation exchanger and a suitable chelating agent are used. With the method in accordance with the invention it is possible for the first time to provide non-carrier-added high-purity 177Lu compounds in milligram amounts for pharmaceutical-medicinal purposes from 176Yb compounds irradiated with thermal neutrons, the radionuclides 177Lu and 176Yb being present in an approximate mass ratio of 1:102 to 1:1010 for purification.
    Type: Application
    Filed: April 12, 2012
    Publication date: October 2, 2014
    Applicant: ITM ISOTOPEN TECHNOLOGIEN MÜNCHEN AG
    Inventors: Sebastian Marx, Mark Harfensteller, Konstantin Zhernosekov, Tuomo Nikula
  • Publication number: 20140296609
    Abstract: Disclosed is a layer structure for epidermal radionuclide therapy (brachytherapy) of a patient comprising, from a patient's view, a proximal adherent layer for applying the layer structure on the skin surface to be treated of a patient; a flexible, transparent carrier layer that from a patient's view is located in a distal direction on the adherent layer; and at least one radionuclide-containing emission layer located on the carrier layer, the adherent layer and the carrier layer with regard to their components and thickness being formed such that they are essentially transparent for ? and ? radiation. The layer structure is suited particularly for radiotherapeutic treatment of the basal-cell carcinoma (BCC) and the squamous cell carcinoma (SCC). With the aid of the layer structure, geometrically complex skin lesions caused by a tumor, as occurring e.g. on the outer edge of the auricle, may be treated easily.
    Type: Application
    Filed: June 6, 2012
    Publication date: October 2, 2014
    Applicant: ITM Isotopen Technologien Munchen AG
    Inventors: Maria Desantis, Oliver Buck, Cesidio Cipriani
  • Publication number: 20140163211
    Abstract: The present invention relates to a 68Ga generator, wherein the 68Ge parent nuclide thereof is attached specifically to a support through a triethoxyphenyl group and continuously disintegrates to 68Ga, the triethoxyphenyl group being covalently bound to a support material through a linker.
    Type: Application
    Filed: June 27, 2013
    Publication date: June 12, 2014
    Applicant: ITM Isotopen Technologien München AG
    Inventors: Konstantin Zhernosekov, Tuomo Nikula
  • Patent number: 8487047
    Abstract: The present invention relates to a 68Ga generator, wherein the 68Ge parent nuclide thereof is attached specifically to a support through a triethoxyphenyl group and continuously disintegrates to 68Ga, the triethoxyphenyl group being covalently bound to a support material through a linker.
    Type: Grant
    Filed: September 28, 2011
    Date of Patent: July 16, 2013
    Assignee: ITM Isotopen Technologien Munchen AG
    Inventors: Konstantin Zhernosekov, Tuomo Nikula
  • Patent number: D836724
    Type: Grant
    Filed: April 16, 2018
    Date of Patent: December 25, 2018
    Assignee: ITM Isotopen Technologien München AG
    Inventor: Markus Kurscheidt
  • Patent number: D837889
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: January 8, 2019
    Assignee: ITM Isotopen Technologien München AG
    Inventor: Markus Kurscheidt