Patents Assigned to ITS
  • Unmanned vehicle searches
    Patent number: 9824596
    Abstract: A method of planning a flight path for a search can include receiving, by a control system, an indication of a search area boundary; receiving, by the control system, an indication of a selected search pattern; determining, by the control system, a flight path based on the search area boundary and the selected search pattern; and transmitting one or more indications of the flight path to an unmanned aerial vehicle.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: November 21, 2017
    Assignees: INSITU, INC., UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Amy Claire Arbeit, Christopher W. Lum
  • Pile with sound abatement for vibratory installations
    Patent number: 9816246
    Abstract: A noise-attenuating pile comprising a pile driving shoe, an outer tube that engages the pile driving shoe, and an inner member that extends through the outer tube and engages the pile driving shoe, wherein the pile is configured to be installed in the ground with either an impact driver or a vibratory driver that engages only the inner member. The inner member is rigidly connected to the driving shoe, and the outer tube is elastically connected to the driving shoe, such that vibrations from the outer tube is substantially isolated from vibrations in the driving shoe.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: November 14, 2017
    Assignee: University of Washington Through its Center for Commercialization
    Inventors: Per G. Reinhall, John Timothy Dardis, II
  • Universal protein tag for double stranded nucleic acid delivery
    Patent number: 9809632
    Abstract: Disclosed herein are chimeric proteins that include one or more double stranded nucleic acid binding domains (dsNABD) and one or more polyHis domains, and compositions that further include a therapeutic double stranded nucleic acid and a targeting ligand bound to the therapeutic double stranded nucleic acid, wherein the dsNABD of the chimeric protein is bound to the therapeutic double stranded nucleic acid, and uses of the compositions to treat disease.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: November 7, 2017
    Assignee: University of Washington Through its Center for Commercialization
    Inventors: Xiaohu Gao, Hong Yan Liu
  • Non-fullerene electron acceptors for organic photovoltaic devices
    Patent number: 9809594
    Abstract: Non-fullerene electron acceptors for highly efficient organic photovoltaic devices are described. The non-fullerene electron acceptors have an extended, rigid, ?-conjugated electron-deficient framework that can facilitate exciton and charge derealization. The non-fullerene electron acceptors can physically mix with a donor polymer and facilitate improved electron transport. The non-fullerene electron acceptors can be incorporated into organic electronic devices, such as photovoltaic cells.
    Type: Grant
    Filed: September 10, 2014
    Date of Patent: November 7, 2017
    Assignee: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Samson A. Jenekhe, Haiyan Li, Taeshik Earmme, Guoqiang Ren
  • Systems and methods for selection-based contextual help retrieval
    Patent number: 9811583
    Abstract: Described herein are systems and methods for selection-based contextual help retrieval. One example method involves (a) receiving first-query data including contextual data, the contextual data indicating a user-interface element type, a user-interface element location, and user-interface element text; (b) determining at least one first-query response based on at least the contextual data; and (c) causing an indication of the determined at least one first-query response to be provided via an output device.
    Type: Grant
    Filed: June 18, 2012
    Date of Patent: November 7, 2017
    Assignee: University of Washington Through Its Center for Commercialization
    Inventors: Parmit K. Chilana, Andrew J. Ko, Jacob O. Wobbrock
  • Methods for retrieval of sequence-verified DNA constructs
    Patent number: 9809904
    Abstract: In some embodiments, methods of recovering a sequence-verified target nucleic acid are provided. In some embodiments, such methods may include tagging each member of a nucleic acid library with a set of adaptor sequences; sequencing the tagged members of the nucleic acid library; and recovering the sequence-verified target nucleic acid from the tagged and sequenced members of the nucleic acid library using a dial-out selection method. In certain embodiments, the members of the nucleic acid library may be tagged with a second set of adaptor sequences.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: November 7, 2017
    Assignee: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Jay Shendure, Jerrod Schwartz, Jacob Kitzman, Rupali Patwardhan, Joseph Hiatt
  • Reagents and methods for treating dental disease
    Patent number: 9809633
    Abstract: Peptide-based reagents, compositions and oral care products containing the peptide-based reagents, and methods for using the peptide-based reagents, compositions, or oral care products to treat dental diseases such as periodontitis, tooth erosion, hypersensitivity, bacterial plaque, dental fluorosis, tooth decay, carries, tooth resorption, and gingival recession, are described.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: November 7, 2017
    Assignee: University of Washington Through its Center for Commercialization
    Inventors: Mehmet Sarikaya, Martha Somerman, Candan Tamerler-Behar, Hanson Fong, Hai Zhang, Mustafa Gungormus
  • Chromophoric polymer dots
    Patent number: 9810693
    Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: November 7, 2017
    Assignee: University of Washington Through its Center for Commercialization
    Inventors: Daniel T. Chiu, Changfeng Wu, Xuanjun Zhang, Jiangbo Yu, Fangmao Ye
  • Method and system for concentrating magnetization of nuclear spins
    Patent number: 9810758
    Abstract: Apparatuses and methods are provided for concentrating the magnetization of nuclear spins within a body, in one apparatus, a body having an electron spin moments and nuclear spin moments may subject to a polarizing magnetic field and a gradient magnetic field, such that a space-varied distribution of magnetic resonant frequencies of respective electron spin moments in the body is induced. The body may then be subject to a time-varying magnetic field configured to induce a spatial gradient of the electron spin magnetization such that concentrations of nuclear spin magnetization are induced. The body may be configured to receive a biological sample such that a concentration of nuclear spin magnetization may diffuse into the biological sample. The apparatus may further include a sensor configured to detect nuclear spin magnetization within the biological sample.
    Type: Grant
    Filed: July 23, 2013
    Date of Patent: November 7, 2017
    Assignee: University of Washington Through its Center for Commercialization
    Inventors: John A. Sidles, Jon Jacky, Joseph L. Garbini, Rico Picone
  • Fenestration template for endovascular repair of aortic aneurysms
    Patent number: 9811613
    Abstract: To provide simple yet accurate stent graft fenestration, a patient-specific fenestration template is used as a guide for graft fenestration. To generate the fenestration template, a patient's medical imaging data such as CT scan data may be used to generate a 3-D digital model of an aorta lumen of the patient. The aorta lumen may encompass one or more branch vessels, which may be indicated on the 3-D digital model. Based on the 3-D digital model or a segment thereof, the fenestration template may be generated, for example, using 3-D printing technology. The fenestration template may include one or more holes or openings that correspond to the one or more branch vessels. To fenestrate a stent graft, the fenestration template is coupled to the stent graft so that the holes or openings on the fenestration template indicate the fenestration locations.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: November 7, 2017
    Assignee: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Daniel F. Leotta, Benjamin Starnes
  • Soluble MIC neutralizing monoclonal antibody for treating cancer
    Patent number: 9803017
    Abstract: Disclosed are compositions and methods relating to antibodies that bind soluble Major Histocompatibility Complex class I chain-related (sMIC). Specifically, disclosed are antibodies designed or selected to inhibit sMIC (e.g. to neutralize sMIC) shed from MIC+ tumors. Further disclosed are methods of using the antibodies for the treatment of MIC-positive cancers.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: October 31, 2017
    Assignee: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventor: Jennifer Wu
  • Highly fluorescent polymer nanoparticle
    Patent number: 9797840
    Abstract: Fluorescent nanoparticles are provided. The nanoparticles are formed from poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-(1-cyanovinylene-1,4-phenylene)]. Also provided are methods for imaging a target to which the nanoparticles are bound.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: October 24, 2017
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Daniel T. Chiu, Changfeng Wu, Fangmao Ye
  • Nanoparticle for targeting brain tumors and delivery of O-benzylguanine
    Patent number: 9784730
    Abstract: Nanoparticle having a crosslinked chitosan-polyethylene oxide oligomer copolymer coating to which O6-benzylguanine is covalently coupled, compositions that include the nanoparticle, and methods for using the nanoparticle to treat brain cancers.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: October 10, 2017
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Miqin Zhang, Richard G. Ellenbogen, Forrest Kievit, John R. Silber, Zachary Stephen, Omid Veiseh
  • Methods and compositions for activation of innate immune responses through RIG-I like receptor signaling
    Patent number: 9775894
    Abstract: Compositions and methods are provided that enable activation of innate immune responses through RIG-I like receptor signaling. The compositions and methods incorporate synthetic nucleic acid pathogen associated molecular patterns (PAMPs) that comprise elements initially characterized in, and derived from, the hepatitis C virus genome.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: October 3, 2017
    Assignee: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Michael J. Gale, Jr., Gretja Schnell, Yueh-Ming Loo
  • COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF NEUROLOGICAL DISEASE
    Publication number: 20170274046
    Abstract: Provided herein are methods, assays and compositions relating to the treatment of neurological diseases and disorders, particularly by modulating expression and/or activity of Bif-1.
    Type: Application
    Filed: June 8, 2017
    Publication date: September 28, 2017
    Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Richard S. Morrison, David Boyu Wang
  • ULTRASOUND BASED METHOD AND APPARATUS FOR STONE DETECTION AND TO FACILITATE CLEARANCE THEREOF
    Publication number: 20170273699
    Abstract: Described herein are methods and apparatus for detecting stones by ultrasound, in which the ultrasound reflections from a stone are preferentially selected and accentuated relative to the ultrasound reflections from blood or tissue. Also described herein are methods and apparatus for applying pushing ultrasound to in vivo stones or other objects, to facilitate the removal of such in vivo objects.
    Type: Application
    Filed: March 7, 2017
    Publication date: September 28, 2017
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Michael Bailey, Bryan Cunitz, Barbrina Dunmire
  • Hydrogenation and disproportionation catalysis
    Patent number: 9770710
    Abstract: Improved catalytic methods are disclosed. The methods include both hydrogenation and disproportionation catalysis. While the reaction conditions for hydrogenation and disproportionation differ, the catalysts disclosed herein can be used for either process. In certain aspects, the methods utilize a catalyst: CpM(N—N)Ln; wherein Cp is a substituted or unsubstituted cyclopentadienyl ligand; wherein M is selected from the group consisting of Ir and Rh; wherein N—N is a substituted or unsubstituted bidentate ligand selected from the group consisting of a bipyridine ligand and a phenanthroline ligand; wherein n is 0 or 1; and wherein when n is 1 L is selected from the group consisting of an anion and a molecule of a solvent.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: September 26, 2017
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Karen I. Goldberg, D. Michael Heinekey, James M. Mayer, Alexander J. M. Miller, Timothy P. Brewster
  • Theragnostic particles
    Patent number: 9765122
    Abstract: The present invention provides viral-based nanoparticles for therapeutic and diagnostic use, and methods for making and using the nanoparticles. Specifically, such nanoparticles comprise decoration-competent viral particles shells such as expanded capsids of phages, stabilized with engineered decoration proteins that have been linked to one or more compounds not naturally occurring on a wild type viral capsid.
    Type: Grant
    Filed: January 20, 2014
    Date of Patent: September 19, 2017
    Assignee: University of Washington Through its Center for Commercialization
    Inventors: Carlos Enrique Catalano, Jenny Ren-Jye Chang
  • Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases
    Patent number: 9765037
    Abstract: Compositions and methods for the treatment of toxoplasmosis, caused by the infectious eukaryotic parasite Toxoplasma gondii (T. gondii) and for the treatment of cryptosporidiosis, caused by the infectious eukaryotic parasites Cryptosporidium parvum (C. parvum) and Cryptosporidium hominus (C. hominus) are described. In particular, the present disclosure is directed to compositions and methods for inhibiting either T. gondii calcium dependent protein kinases (TgCDPKs) or C. parvum and C. hominus calcium dependent protein kinases (CpCDPKs) using pyrazolopyrimidine and/or imidazo[1,5-a]pyrazine inhibitors, of the formula, wherein the variables X, Y, Z, L, R1, and R3 are defined herein.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: September 19, 2017
    Assignee: University of Washington Through its Center for Commercialization
    Inventors: Wesley C. Van Voorhis, Wilhelmus G. J. Hol, Eric T. Larson, Dustin James Maly, Ethan Merritt, Kayode K. Ojo
  • Methods of reducing motion artifacts for optical coherence tomography angiography
    Patent number: 9759544
    Abstract: A method for reducing motion artifacts in optical coherence tomography (OCT) angiography images is disclosed. The method is applied to the intensity or complex OCT data prior to applying the motion contrast analysis and involves determining sub-pixel level shifts between at least two B-scans repeated approximately at the same location and applying the sub-pixel level shifts to the B-scans to be able to correct for motion and accurately determine motion contrast signal. A preferred embodiment includes the use of 2D cross correlations to register a series of B-scans in both the axial (z-) and lateral (x-) dimensions and a convolution approach to achieve sub-pixel level frame registration.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: September 12, 2017
    Assignees: Carl Zeiss Meditec, Inc., University of Washington through its Center for Commercialization
    Inventors: Lin An, Ruikang Wang, Utkarsh Sharma