Abstract: Intestine-specific delivery of an opioid antagonist can be accomplished without substantial central nervous system effects by administering the antagonist orally in the form of the glucuronide derivative.
Type:
Grant
Filed:
March 26, 1988
Date of Patent:
September 27, 1988
Assignee:
Ivax Laboratories, Inc.
Inventors:
Ronald R. Tuttle, Ross Dixon, Maciej M. Smulkowski