Abstract: Provided is a device for excitation of a fluorescent component associated with a predetermined target circulating in blood flowing through a blood vessel of a living being. The device includes a clamping device, a coherent light source that emits light causing excitation of the fluorescent component forming a conjugate with the predetermined target in the blood stream. A fluorescence sensor senses and measures a fluorescent effect exhibited by the fluorescent component forming a portion of the conjugate in response to excitation of the fluorescent component by the light emitted by the coherent light source. Optical fibers transmit the emitted light between the light source and the clamping device, and the fluorescent effect exhibited by the fluorescent component of the conjugate between the clamping device and the sensor.

Abstract: The invention is a nano-entity conjugate for use in an in vivo immunomagnetic hyperthermia system for the detection and treatment of any cell or virus having a target surface receptor which encompasses a technology platform that can be used for both real-time monitoring of any cell or virus having a target surface receptor and as a delivery platform for certain types of treatment that are conducive for in vivo applications. The system allows of cell or virus enumeration; cell or virus capture; and cell or virus removal from the patient's circulatory system in-vivo using immunomagnetic hyperthermia. The application of immunomagnetic hyperthermia may actually diminish and eventually stop the progression of cancer and other blood borne or blood affected diseases.