Patents Assigned to IVS Institut des Vaisseaux et du Sang
  • Mutated netrin 4, fragments thereof and uses thereof as drugs
    Patent number: 8420780
    Abstract: Proteins having the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 4, or fragments of said sequences are provided. The protein fragments are represented by the sequences of SEQ ID NO: 2q, q varying from 3 to 36, and the sequences of SEQ ID NO: 185 to SEQ ID NO: 209. Nucleotide sequences coding for said proteins are also provided.
    Type: Grant
    Filed: January 21, 2008
    Date of Patent: April 16, 2013
    Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), Centre National de la Recherche Scientifique, IVS Institut des Vaisseaux et du Sang
    Inventors: Laurence Leconte, Esma Lejmi, Isabelle Clarisse Solange Plouët, Claire Charlotte Plouët, Anne Florence Plouët
  • Mutated netrin-4, fragments thereof and their use as medicines
    Patent number: 8168593
    Abstract: A peptide fragment of the netrin-4 protein and nucleic acids coding for the peptide are described. The peptide can inhibit endothelial cell proliferation and cell migration, as well as activate the proliferation and migration of pericytes and smooth muscle cells. Pharmaceutical formulations containing the peptide and/or the nucleic acids can be used to treat a variety of tumoral and non-tumoral pathologies.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: May 1, 2012
    Assignees: Centre National de la Recherche Scientifique, IVS Institut des Vaisseaux et du Sang
    Inventors: Jean Plouet, Monica Alemany
  • MUTATED NETRIN - 4, FRAGMENTS THEREOF AND THEIR USE AS MEDICINES
    Publication number: 20110280876
    Abstract: A peptide fragment of the netrin-4 protein and nucleic acids coding for the peptide are described. The peptide can inhibit endothelial cell proliferation and cell migration, as well as activate the proliferation and migration of pericytes and smooth muscle cells. Pharmaceutical formulations containing the peptide and/or the nucleic acids can be used to treat a variety of tumoral and non-tumoral pathologies.
    Type: Application
    Filed: June 29, 2011
    Publication date: November 17, 2011
    Applicants: IVS INSTITUT DES VAISSEAUX ET DU SANG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: JEAN PLOUET, Monica Alemany
  • Mutated netrin-4, fragments thereof and their use as medicines
    Patent number: 7999072
    Abstract: Described is use of a netrin selected among netrin-4, mutated netrin-4, netrin-1, netrin G1 or netrin-3, or one of their fragments or a nucleotide sequence encoding one of the netrins or one of the fragments, or an anti-idiotypic antibody of one of the netrins or of one of the fragments, or of a Fab fragment of the anti-idiotypic antibodies, for preparing a medicine for preventing or treating tumoral or non-tumoral pathologies.
    Type: Grant
    Filed: November 22, 2005
    Date of Patent: August 16, 2011
    Assignees: Centre National de la Recherche Scientifique (CNRS), IVS Institut des Vaisseaux et du Sang
    Inventors: Jean Plouét, Monica Alemany
  • MUTATED NETRIN 4, FRAGMENTS THEREOF AND USES THEREOF AS DRUGS
    Publication number: 20100247520
    Abstract: The present invention relates to a protein comprising or consisting of one of the following sequences: the sequence SEQ ID NO: 2 or SEQ ID NO: 4, or a fragment of said sequence represented by one of the sequences SEQ ID NO: 2q, q varying from 3 to 36, or the sequence SEQ ID NO: 185 to SEQ ID NO: 209. It also relates to a nucleotide sequence coding for said protein.
    Type: Application
    Filed: January 21, 2008
    Publication date: September 30, 2010
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, IVS INSTITUT DES VAISSEAUX ET DU SANG, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA REC
    Inventors: Jean Plouet, Isabelle Clarisse Solange Plouet, Claire Charlotte Plouet, Anne Florence Plouet, Laurence Leconte, Esma Lejmi