Abstract: An improved refrigeration manifold having an unrestricted and uncomplicated flow path as well as a simple and efficient valve system is disclosed. The refrigeration manifold includes a manifold body having a first passage extending horizontally through the body and second and third passages extending vertically through the body to form the high and low sides of the manifold. One or more passages extend through the body from the first passage to the bottom of the manifold body for connection to a vacuum or refrigeration source. First and second ball valves are disposed in the first passage for selectively opening and closing the first passage. Third and fourth ball valves may be provided in fourth and fifth passages which are provided for connection to a vacuum and charging source, respectively. The ball valves are operable by moving a lever through an arc of 90.degree. for quick turn off.