Patents Assigned to J. RETTENMAIER & SÖHNE GMBH & CO. KG
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Patent number: 10166185Abstract: The present invention is directed to an excipient which can be used to manufacture tablets containing oily active ingredients such as oily drugs, and pharmaceutical compositions containing the same.Type: GrantFiled: June 9, 2016Date of Patent: January 1, 2019Assignee: J. Rettenmaier & Söhne GmbH + Co KGInventors: Anthony Carpanzano, Michael Nagel
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Publication number: 20160361261Abstract: The present invention is directed to an excipient which can be used to manufacture tablets containing oily active ingredients such as oily drugs, and pharmaceutical compositions containing the same.Type: ApplicationFiled: June 9, 2016Publication date: December 15, 2016Applicant: J. Rettenmaier & Söhne GmbH + Co KGInventors: Anthony Carpanzano, Michael Nagel
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Publication number: 20140212563Abstract: A compound comprises microcrystalline cellulose (MCC) in colloidal form and two different qualities of carboxymethyl cellulose (CMC), wherein the MCC and the two different qualities of CMC are combined by co-processing, wherein the two different qualities of CMC have different degrees of substitution (DS), wherein a low-substituted CMC is present with a DS of 0.6 to 0.9 and a high-substituted CMC is present with a DS of 1.10 to 1.45, wherein a percentage of CMC in the compound is between 5% and 18% by weight relating to a dry matter, and wherein the co-processing is done by homogenization.Type: ApplicationFiled: April 3, 2014Publication date: July 31, 2014Applicant: J. RETTENMAIER & SÖHNE GMBH & CO. KGInventors: Georg Bache, Ralf Ungerer
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Publication number: 20090169621Abstract: A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.Type: ApplicationFiled: December 15, 2008Publication date: July 2, 2009Applicant: J. Rettenmaier & Soehne GmbH + Co. KGInventors: Bob Sherwood, John H. Staniforth, Edward Hunter
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Publication number: 20070011904Abstract: A process for preparing agglomerated particles comprising a) providing an active agent in a form suitable for spray drying; and b) combining the active agent with dry silicified microcrystalline cellulose in a dryer to form agglomerated particles.Type: ApplicationFiled: July 10, 2006Publication date: January 18, 2007Applicant: J. Rettenmaier & Soehne GmbH + Co. KGInventors: Bob Sherwood, Joseph Zeleznik, David Schaible, Theodore Montalto
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Publication number: 20060228487Abstract: A process for preparing agglomerated particles comprising a) providing an active agent in a form suitable for spray drying; and b) combining the active agent with dry silicified microcrystalline cellulose in coating pan or fluid-bed dryer to form agglomerated particles.Type: ApplicationFiled: April 11, 2005Publication date: October 12, 2006Applicant: J. Rettenmaier & Söehne GmbH + Co. KGInventors: David Schaible, Bob Sherwood
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Publication number: 20060008522Abstract: A method of preparing an excipient composition includes forming an aqueous slurry containing a mixture of microcrystalline cellulose in the form of a wet cake and a surfactant, said surfactant being present in an amount from about 0.1% to about 0.5% by weight of the wet-cake microcrystalline cellulose; and drying said slurry to obtain an excipient comprising a plurality of agglomerated particles of microcrystalline cellulose in intimiate association with said surfactant. The excipient may be mixed with a therapeutically active agent to form a dosage form. The surfactant provides a hydrophobic boundary at cellulose surfaces, and improves absorptivity of the therapeutically active agent.Type: ApplicationFiled: July 5, 2005Publication date: January 12, 2006Applicant: J. Rettenmaier & Soehne GmbH + Co. KGInventors: John Staniforth, Edward Hunter, Bob Sherwood
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Publication number: 20050196439Abstract: A process for preparing agglomerated particles comprising a) providing an active agent in a form suitable for spray drying; and b) combining the active agent with dry silicified microcrystalline cellulose in a dryer to form agglomerated particles.Type: ApplicationFiled: October 21, 2004Publication date: September 8, 2005Applicant: J. Rettenmaier & Soehne GmbH + Co. KGInventors: Bob Sherwood, Joseph Zeleznik, David Schaible, Theodore Montalto
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Patent number: 6936277Abstract: A method of preparing an excipient composition includes forming an aqueous slurry containing a mixture of microcrystalline cellulose in the form of a wet cake and a surfactant, said surfactant being present in an amount from about 0.1% to about 0.5% by weight of the wet-cake microcrystalline cellulose; and drying said slurry to obtain an excipient comprising a plurality of agglomerated particles of microcrystalline cellulose in intimate association with said surfactant. The excipient may be mixed with a therapeutically active agent to form a dosage form. The surfactant provides a hydrophobic boundary at cellulose surfaces, and improves absorptivity of the therapeutically active agent.Type: GrantFiled: May 14, 2002Date of Patent: August 30, 2005Assignee: J. Rettenmaier & Soehne GmbH & Co. KGInventors: John N. Staniforth, Edward A. Hunter, Bob E. Sherwood
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Publication number: 20050145351Abstract: In one embodiment of the invention is disclosed a process for the production of microcrystalline cellulose comprising hydrolyzing pulp with a sufficient amount of active oxygen in an acidic environment in a one step process; and recovering the microcrystalline cellulose; wherein said recovered microcrystalline cellulose has a color lightness (L*) greater than the color lightness (L*) of the pulp starting material.Type: ApplicationFiled: October 4, 2004Publication date: July 7, 2005Applicant: J. Rettenmaier & Soehne GmbH + Co. KGInventors: David Schaible, Bob Sherwood
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Publication number: 20050147673Abstract: The present invention provides an improved process for the preparation of a agglomerated solid dosage form, comprising: (1) preparing an aqueous slurry of (a) microcrystalline cellulose; (b) a microcrystalline cellulose compressibility augmenting agent which (i) physically restricts the proximity of the interface between adjacent cellulose surfaces; (ii) inhibits interactions between adjacent cellulose surfaces, for example, via the creation of a hydrophobic boundary at cellulose surfaces; or (iii) accomplishes both (i) and (ii) above; and (c) an active agent; (2) thereafter drying the resultant aqueous slurry in a manner which inhibits quasi-hornification, thereby obtaining an agglomerated material which is directly compressible into a solid dosage form.Type: ApplicationFiled: February 8, 2005Publication date: July 7, 2005Applicant: J. Rettenmaier & Soehne GmbH + Co. KGInventors: John Staniforth, Edward Hunter, Bob Sherwood, Clifford Davidson
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Patent number: 6866867Abstract: The present invention provides an improved process for the preparation of a agglomerated solid dosage form, comprising: (1) preparing an aqueous slurry of (a) microcrystalline cellulose; (b) a microcrystalline cellulose compressibility augmenting agent which (i) physically restricts the proximity of the interface between adjacent cellulose surfaces; (ii) inhibits interactions between adjacent cellulose surfaces, for example, via the creation of a hydrophobic boundary at cellulose surfaces; or (iii) accomplishes both (i) and (ii) above; and (c) an active agent; (2) thereafter drying the resultant aqueous slurry in a manner which inhibits quasi-hornification, thereby obtaining an agglomerated material which is directly compressible into a solid dosage form.Type: GrantFiled: December 13, 2001Date of Patent: March 15, 2005Assignee: J. Rettenmaier & Soehne GmbH + Co. KGInventors: John N. Staniforth, Bob E. Sherwood, Edward A. Hunter, Clifford M. Davidson
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Patent number: 6858231Abstract: A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.Type: GrantFiled: January 8, 2003Date of Patent: February 22, 2005Assignee: J. Rettenmaier & Soehne GmbH + Co. KGInventors: Bob E. Sherwood, John H. Staniforth, Edward A. Hunter
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Patent number: 6852336Abstract: Direct compressed solid pharmaceutical dosage forms containing: a) from about 40 to about 95% by weight acetaminophen; b) from about 1 to about 60% by weight of a direct compression vehicle comprising microcrystalline cellulose; and c) from about 0.01 to about 4.0% by weight of a pharmaceutically-acceptable lubricant are disclosed. The acetaminophen and direct compression vehicle are combined under high shear conditions which are sufficient to transform acetaminophen and direct compression vehicle into a homogenous granulate without degradation. In preferred aspects of the invention, the lubricant is also combined with the acetaminophen and direct compression vehicle under high shear conditions. Methods of preparing the directly compressed solid pharmaceutical dosage forms and methods of treatment with the dosage forms are also disclosed. The methods are particularly well suited for preparing directly compressed dosage forms containing high load (i.e.Type: GrantFiled: April 1, 2002Date of Patent: February 8, 2005Assignee: J. Rettenmaier & Soehne GmbH + Co. KGInventors: Edward A. Hunter, Bob E. Sherwood, Joseph A. Zeleznik
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Publication number: 20050013861Abstract: A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.Type: ApplicationFiled: May 20, 2004Publication date: January 20, 2005Applicant: J. Rettenmaier & Soehne GmbH + Co. KGInventors: Bob Sherwood, John Staniforth, Edward Hunter
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Publication number: 20040265374Abstract: A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide. An extra low moisture excipient is provided which exhibits improved compressibility as compared to conventional microcrystalline cellulose, while providing a moisture content of of from about 0.5 to 2.5% LOD, preferably between about 0.5 and about 1.8%, more preferably between 0.8 and 1.5%, and most preferably between about 0.8 and about 1.2%.Type: ApplicationFiled: April 2, 2004Publication date: December 30, 2004Applicant: J. Rettenmaier & Soehne GmbH + Co. KGInventors: John N. Staniforth, Bob E. Sherwood, Edward A. Hunter