Patents Assigned to J. Stefan Institute
  • Cathepsin-binding compounds bound to a carrier and their diagnostic use
    Patent number: 10668175
    Abstract: The invention relates to Cathepsin-binding compounds bound to a carrier comprising a diagnostic moiety, for use in the diagnosis of inflammatory diseases, and/or for use in the diagnosis of neoplastic diseases, wherein the Cathepsin-binding compound binds to inflammatory cells of the tumour stroma. The invention also relates to Cathepsin B-targeting compounds and Cathepsin B-binding and liposome-binding compounds.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: June 2, 2020
    Assignee: J. Stefan Institute
    Inventors: Olga Vasiljeva, Georgy Mikhaylov, Boris Turk, Norbert Schaschke
  • Crystal structure of Autolysin E, method of producing the crystal and its use in screening methods
    Patent number: 10428320
    Abstract: The invention concerns the determination and evaluation of the crystal structure of autolysin E (AtlE) of Staphylococcus aureus (S. aureus), or a crystallizable fragment of AtlE, a method for producing a crystal of AtlE and the respective crystallization kit, and its use in a method for screening an inhibitor of the N-acetylglucosaminidase activity of AtlE, for obtaining atomic spatial relationship data, and for identifying a binding compound of AtlE, e.g. by in silico screening.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: October 1, 2019
    Assignee: J. Stefan Institute
    Inventors: Marko Miheli{hacek over (c)}, Miha Renko, Dusan Turk
  • Cathepsin-binding compounds bound to a carrier and their diagnostic use
    Patent number: 9827337
    Abstract: The invention relates to Cathepsin-binding compounds bound to a carrier comprising a diagnostic moiety, for use in the diagnosis of inflammatory diseases, and/or for use in the diagnosis of neoplastic diseases, wherein the Cathepsin-binding compound binds to inflammatory cells of the tumour stroma. The invention also relates to Cathepsin B-targeting compounds and Cathepsin B-binding and liposome-binding compounds.
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: November 28, 2017
    Assignee: J. Stefan Institute
    Inventors: Olga Vasiljeva, Georgy Mikhaylov, Boris Turk, Norbert Schaschke
  • CATHEPSIN-BINDING COMPOUNDS BOUND TO A CARRIER AND THEIR DIAGNOSTIC USE
    Publication number: 20140227175
    Abstract: The invention relates to Cathepsin-binding compounds bound to a carrier comprising a diagnostic moiety, for use in the diagnosis of inflammatory diseases, and/or for use in the diagnosis of neoplastic diseases, wherein the Cathepsin-binding compound binds to inflammatory cells of the tumour stroma. The invention also relates to Cathepsin B-targeting compounds and Cathepsin B-binding and liposome-binding compounds.
    Type: Application
    Filed: June 22, 2012
    Publication date: August 14, 2014
    Applicant: J. Stefan Institute
    Inventors: Olga Vasiljeva, Georgy Mikhaylov, Boris Turk, Norbert Schaschke