Abstract: Described are pharmacological compositions comprising a gum resin; a pharmacologically active agent and a topically acceptable volatile solvent for the gum resin and active agent. Also described are methods for the transdermal or transmucosal delivery of a pharmacologically active agent using such compositions.

Abstract: The invention provides a biological dressing for treatment of a condition of the skin, mucosa, teeth or other tissue within or proximate to the oral cavity of a subject, the biological dressing comprised of a gum resin, a topically acceptable volatile solvent, and an oral care agent. The gum resin is present in a suitable amount that the composition, when the solvent evaporates, will dry to form a solid coating that sticks to the tissue to which the composition is applied and maintain the oral care agent over a sustained period of time in contact with sites on the tissue exhibiting symptoms of the condition. Methods are provided for treating symptoms of oral condition with such a oral care composition.

Abstract: A dual chamber applicator includes an elongated tube having a sealed end and an open end, a first ampoule disposed in the elongated tube and containing a first composition including a pharmaceutically active agent and optionally a first volatile solvent, water, or a combination thereof, a second ampoule disposed in the elongated tube and containing a second composition including a resin based tincture, a second volatile solvent and water, and an applicator device provided at the open end of the elongated tube. The first composition is configured to combine with the second composition within the elongated tube to form a medicine to be delivered to a mucosal site or a skin site. The applicator device is configured to control flow of the medicine out of the open end of the elongated tube and deliver the medicine via topical, transdermal or transmucosal delivery.

Abstract: Described are pharmacological compositions comprising a gum resin; a pharmacologically active agent and a topically acceptable volatile solvent for the gum resin and active agent. Also described are methods for the transdermal or transmucosal delivery of a pharmacologically active agent using such compositions.

Abstract: A method of rapid transbuccal delivery of an active agent into the bloodstream is provided. The method can include providing a pharmaceutical composition comprising the active agent, resin and a volatile solvent and, optionally, water. In some embodiments, the method achieves a Tmax 60 minutes or less, an onset of therapeutic effect of 60 minutes or less, and/or achieves therapeutic serum levels of the active agent within 60 minutes or less. Related compositions also are provided.

Abstract: Described are pharmacological compositions comprising a gum resin; a pharmacologically active agent and a topically acceptable volatile solvent for the gum resin and active agent. Also described are methods for the transdermal or transmucosal delivery of a pharmacologically active agent using such compositions.

Abstract: The invention provides a biological dressing for treatment of a dermatological disease comprised of one or more resins or other film-forming agents, a topically acceptable volatile solvent, and a pharmacologically active agent. The combined one or more resins are present in a suitable amount such that the composition, when the solvent evaporates, will dry to form a solid coating that sticks to the skin, nail or mucosal membrane to which the composition is applied, and maintain the pharmacologically active agent over a sustained period of time in contact with sites on the skin or mucosal membranes exhibiting symptoms of the disease. Methods are provided for treating symptoms of dermatological diseases with such a pharmacological composition.