Abstract: The present invention relates to antibiotics, anti-inflammatory agents, antihyperlipidemia agents, antidiabetes agents and anticancer agents, of which medical treatment materials are extracted by hot water or organic solvent from 20-year (or older) perennial old platycodon (i.e., old platycodon) with various physiological effects, or selective mixture of these extracts and other allowable herbal medicines or herbal medicine extracts. The old platycodon extracts have further enhanced effects than conventional medicines or 2-4 year old common platycodon, in terms of antibiotic activity, lipid metabolism improving activity, blood glucose level lowering activity, inhibition activity against adhesion of cancer cells immunity increasing effect, anti-arthritis effect, etc.