Abstract: Substituted N-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides, their N-oxide forms, their pharmaceutically acceptable acid addition salts and stereochemically isomeric forms having gastrointestinal motility stimulating properties, compositions containing the same, and methods of treating warm-blooded animals suffering from motility disorders of the gastrointestinal system.
Type:
Grant
Filed:
September 2, 1988
Date of Patent:
December 4, 1990
Assignee:
Janssen Pharmaceutical N.V.
Inventors:
Georges H. P. Van Daele, Freddy F. Vlaeminck, Michel A. J. De Cleyn
Abstract: Novel N-(4-piperidinyl)bicyclic condensed 2-imidazolamine derivatives and their pharmaceutically acceptable acid addition salts having anti-histaminic properties, compositions containing the same, and methods of treating allergic diseases in warm-blooded animals.
Type:
Grant
Filed:
April 18, 1988
Date of Patent:
January 30, 1990
Assignee:
Janssen Pharmaceutical N.V.
Inventors:
Frans E. Janssens, Joseph L. G. Torremans, Gaston S. M. Diels
Abstract: Novel 5H-thiazolo- and 5H-1,3,4-thiadiazolo[3,2-a]-pyrimidin-5-one and 3,4-dihydro-2H,6H-pyrimido[2,1-b][1,3]-thiazin-6-one derivatives, which compounds are useful psychotropic agents.