Patents Assigned to Janssen Pharmaceutics N.V.
  • Non-steroidal IL-5 inhibitors, processes and intermediates for their preparation and pharmaceutical compositions comprising said inhibitors
    Patent number: 6911444
    Abstract: The present invention relates to IL-5 inhibiting 6-azauracil derivatives useful for treating eosinophil-dependent inflammatory diseases, to processes and intermediates for their preparation as well as to pharmaceutical compositions comprising the said derivatives. It further relates to the use of such derivatives as a medicine, and to processes for marking a receptor or imaging an organ using the said derivatives.
    Type: Grant
    Filed: February 14, 2002
    Date of Patent: June 28, 2005
    Assignee: Janssen Pharmaceutics N.V.
    Inventors: Jean Fernand Armand Lacrampe, Eddy Jean Edgard Freyne, Frederik Dirk Deroose, Jérôme Michel Claude Fortin, Erwin Coesemans
  • Gastrokinetic monocyclic benzamides of 3-or 4-substituted 4-(aminoethyl)-piperidine derivatives
    Patent number: 6750349
    Abstract: The present invention of compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, R1 is C1-6alkyloxy, C2-6alkenyloxy or C2-6alkynyl-oxy; R2 is hydrogen, C1-6alkyl C1-6alkyloxy; R3 is hydrogen or halo; R4 is hydrogen or C1-6alkyl; R5 is hydrogen or C1-6alkyl; L is C3-6cycloalkyl, C5-6cycloalkanone, C2-6alkenyl, or L is a radical of formula —Alk—R6—, Alk-X—R7, —Alk—Y—C(═O)—R9, or —Alk—Y—C(═O)—NR11R12 wherein each Alk is C1-12alkanediyl; and R6 is hydrogen, cyano, C1-6alkylsulfonylamino, C3-6cycloalkyl, C5-6cycloalkanone, or a heterocyclic ringsystem; R7 is hydrogen, C1-6alkyl, hydroxyC1-6alkyl, C3-6cycloalkyl, or a heterocyclic ringsystem; X is O, S, SO2 or NR8; said R8 being hydrogen or C1-6alkyl; R9 is hydrogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkyloxy or hydroxy; Y is NR10 or a direct bond; said R10 being hydrogen, or
    Type: Grant
    Filed: June 5, 2002
    Date of Patent: June 15, 2004
    Assignee: Janssen Pharmaceutics, N.V.
    Inventors: Jean-Paul René Marie André Bosmans, Michel Anna Jozef De Cleyn, Michel Surkyn
  • Use of 5HT3 antagonists for promoting intestinal lavage
    Patent number: 6555546
    Abstract: The present invention is concerned with the use of 5HT3 antagonists for promoting intestinal lavage, especially in combination with an osmotic agent.
    Type: Grant
    Filed: March 8, 2001
    Date of Patent: April 29, 2003
    Assignee: Janssen Pharmaceutics, N.V.
    Inventor: Antonius A. H. P. Megens
  • Cisapride extended release
    Patent number: 6153623
    Abstract: The present invention concerns extended release formulations comprising cisapride-(L)-tartrate, in particular an oral formulation, the use thereof as a medicine, especially in treating gastrokinetic disorders.
    Type: Grant
    Filed: April 23, 1997
    Date of Patent: November 28, 2000
    Assignee: Janssen Pharmaceutic N.V.
    Inventors: Eugene Marie Jozef Jans, Paul Marie Victor Gilis