Patents Assigned to Janssen Research & Development, LLC
  • Patent number: 9012159
    Abstract: A method for identifying a compound which modulates the activity of acyl-coA: diacylglycerol acyltransferase comprises the steps of contacting a stable isotope labeled fatty acid with cells in either presence or absence of the compound, extracting the cells with isopropyl alcohol, and determining the level of a stable isotope labeled triglyceride in the presence or absence of the compound; wherein a change in the level of the stable isotope labeled triglyceride indicates that the compound modulates the DGAT activity.
    Type: Grant
    Filed: January 7, 2010
    Date of Patent: April 21, 2015
    Assignee: Janssen Research & Development, LLC
    Inventors: Jian-Shen Qi, Wensheng Lang, Margery A. Connelly
  • Patent number: 8852556
    Abstract: A method for evaluating the effect of a compound on vasomotor response in vivo comprises the steps of administering said compound to a rabbit and measuring the diameter of the vessel lumen of a central ear artery of said rabbit in comparison with the baseline diameter of the vessel lumen of said central ear artery of said rabbit, said baseline diameter being measured prior to the administration of said compound.
    Type: Grant
    Filed: October 21, 2009
    Date of Patent: October 7, 2014
    Assignee: Janssen Research & Development LLC
    Inventors: Tom Jay Parry, Bruce P. Damiano, Edward C. Giardino, Margery A. Connelly
  • Patent number: 8313920
    Abstract: A method of screening a compound which modulates dipeptidyl peptidase I (DPPI) activities comprises the steps of adding a peptide substrate of DPPI to a reaction mixture which comprises DPPI and a compound, wherein the peptide substrate of DPPI has at least 3 amino acids and binds to a binding site of DPPI in addition to the S1-S2 site; and measuring the molecular weight of the substrate, wherein a change in the molecular weight of the substrate is indicative of the presence of DPPI activity.
    Type: Grant
    Filed: October 21, 2009
    Date of Patent: November 20, 2012
    Assignee: Janssen Research & Development, LLC
    Inventors: Matthew Olson, Matthew Todd