Patents Assigned to Japan as Represented by the Director of Chubu National Hospital
  • Antibody recognizing GM1 ganglioside-bound amyloid ?-protein and DNA encoding the antibody
    Patent number: 7339035
    Abstract: It is intended to provide an antibody efficacious in diagnosing, preventing or treating Alzheimer's disease, DNA encoding the antibody, a method of screening a drug and drugs. The amino acid sequence and the gene sequence of the variable region of an antibody, which specifically recognizes a GM1 ganglioside-bound amyloid ?-protein occurring in the early stage of ?-amyloid fibril formation, are determined. Based on the data of the amino acid sequence and the gene sequence thus obtained, an antibody is designed.
    Type: Grant
    Filed: February 2, 2004
    Date of Patent: March 4, 2008
    Assignees: Medical & Biological Laboratories Co., Ltd., Japan as Represented by the Director of Chubu National Hospital
    Inventors: Katsuhiko Yanagisawa, Masao Shibata
  • Antibody recognizing GM1 ganglioside-bound amyloid beta-protein and DNA encoding the antibody
    Publication number: 20040181042
    Abstract: It is intended to provide an antibody efficacious in diagnosing, preventing or treating Alzheimer's disease, DNA encoding the antibody, a method of screening a drug and drugs. The amino acid sequence and the gene sequence of the variable region of an antibody, which specifically recognizes a GM1 ganglioside-bound amyloid &bgr;-protein occurring in the early stage of &bgr;-amyloid fibril formation, are determined. Based on the data of the amino acid sequence and the gene sequence thus obtained, an antibody is designed.
    Type: Application
    Filed: February 2, 2004
    Publication date: September 16, 2004
    Applicants: MEDICAL & BIOLOGICAL LABORATORIES CO., LTD, JAPAN AS REPRESENTED BY THE DIRECTOR OF CHUBU NATIONAL HOSPITAL
    Inventors: Katsuhiko Yanagisawa, Masao Shibata