Patents Assigned to Japan Biological Informatics Consortium
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Publication number: 20220090100Abstract: The present invention provides a method for producing a modified compound, including the following steps: (1) a step of cleaving in vitro using a CRISPR/Cas9 system, a target site in a gene cluster involved in the biosynthesis of a compound, (2) a step of connecting using Gibson assembly in vitro the gene cluster cleaved in step (1) and a polynucleotide for modification, and (3) a step of expressing the modified gene cluster obtained in step (2) in a microorganism expression system.Type: ApplicationFiled: January 30, 2020Publication date: March 24, 2022Applicant: JAPAN BIOLOGICAL INFORMATICS CONSORTIUMInventors: Kazuo SHINYA, Haruo IKEDA, Mamoru KOMATSU, Junko HASHIMOTO, Ikuko KOZONE, Takuya HASHIMOTO, Kei KUDO
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Patent number: 8951801Abstract: Reprogramming substances capable of substituting for Klf4, selected from the group consisting of members of the IRX family (e.g., IRX6), members of the GLIS family (e.g., GLIS1), members of the PTX family (e.g., PITX2), DMRTB1, and nucleic acids that encode the same, are provided. Also provided are a method of producing iPS cells, comprising the step of introducing into a somatic cell both one or more kinds of the above-described nuclear reprogramming substances and a substance capable of inducing iPS cells from a somatic cell when combined with Klf4. Still also provided are iPS cells comprising an extraneous nucleic acid that encodes any one of the above-described nuclear reprogramming substances, that can be obtained by the method, and a method of producing somatic cells by inducing the iPS cells to differentiate.Type: GrantFiled: February 19, 2010Date of Patent: February 10, 2015Assignees: Kyoto University, National Institute of Advanced Industrial Science and Technology, Japan Biological Informatics ConsortiumInventors: Shinya Yamanaka, Naoki Goshima, Momoko Maekawa, Yoshifumi Kawamura, Hiromi Mochizuki
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Patent number: 8927277Abstract: Provided are a method of improving the efficiency of establishment of iPS cells, comprising the step of contacting one or more substances selected from the group consisting of members of the GLIS family (e.g., GLIS1) and nucleic acids that encode the same and one or more substances selected from the group consisting of members of the Klf family and nucleic acids that encode the same, with a somatic cell, an iPS cell comprising an exogenous nucleic acid that encodes a member of the GLIS family or a member of the Klf family, that can be obtained by the method, and a method of producing a somatic cell by inducing the differentiation of the iPS cell.Type: GrantFiled: February 16, 2011Date of Patent: January 6, 2015Assignees: Kyoto University, National Institute of Advanced Industrial Science and Technology, Japan Biological Informatics ConsortiumInventors: Shinya Yamanaka, Naoki Goshima, Momoko Maekawa, Yoshifumi Kawamura, Hiromi Mochizuki
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Publication number: 20130029423Abstract: Provided are a method of improving the efficiency of establishment of iPS cells, comprising the step of contacting one or more substances selected from the group consisting of members of the GLIS family (e.g., GLIS1) and nucleic acids that encode the same and one or more substances selected from the group consisting of members of the Klf family and nucleic acids that encode the same, with a somatic cell, an iPS cell comprising an exogenous nucleic acid that encodes a member of the GLIS family or a member of the Klf family, that can be obtained by the method, and a method of producing a somatic cell by inducing the differentiation of the iPS cell.Type: ApplicationFiled: February 16, 2011Publication date: January 31, 2013Applicants: Kyoto University, Japan Biological Informatics Consortium, National Institute of Advanced Industrial Science and TechnologyInventors: Shinya Yamanaka, Naoki Goshima, Momoko Maekawa, Yoshifumi Kawamura, Hiromi Mochizuki
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Publication number: 20120052583Abstract: Reprogramming substances capable of substituting for Klf4, selected from the group consisting of members of the IRX family (e.g., IRX6), members of the GLIS family (e.g., GLIS1), members of the PTX family (e.g., PITX2), DMRTB1, and nucleic acids that encode the same, are provided. Also provided are a method of producing iPS cells, comprising the step of introducing into a somatic cell both one or more kinds of the above-described nuclear reprogramming substances and a substance capable of inducing iPS cells from a somatic cell when combined with Klf4. Still also provided are iPS cells comprising an extraneous nucleic acid that encodes any one of the above-described nuclear reprogramming substances, that can be obtained by the method, and a method of producing somatic cells by inducing the iPS cells to differentiate.Type: ApplicationFiled: February 19, 2010Publication date: March 1, 2012Applicants: KYOTO UNIVERSITY, National Institute of Advances Industtrial Science and Technology, JAPAN BIOLOGICAL INFORMATICS CONSORTIUMInventors: Shinya Yamanaka, Naoki Goshima, Momoko Maekawa, Yoshifumi Kawamura, Hiromi Mochizuki
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Publication number: 20100262376Abstract: Provided is an apparatus by which a nucleic acid may be analyzed quickly and precisely.Type: ApplicationFiled: July 24, 2008Publication date: October 14, 2010Applicants: The University of Tokyo, Japan Biological Informatics ConsortiumInventors: Tsutomu Suzuki, Hiroki Ueda
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Publication number: 20050095629Abstract: Multi-dimensional scaling is used to solve characteristic polynomials of similarity matrixes, in order to determine a minimal-number SNP set (htSNPs (haplotype-tagging SNPS)) for identifying an arbitrary number of haplotypes in blocks with strong linkage disequilibrium. Thus, unnecessary SNP typing in blocks with strong linkage disequilibrium can be avoided.Type: ApplicationFiled: September 10, 2004Publication date: May 5, 2005Applicants: NEC Corporation, Mitsubishi Research Institute, Inc., Japan Biological Informatics ConsortiumInventors: Toshio Furuta, Naoyuki Kamatani, Yoshihiro Nakamura, Toshikazu Ito, Eisuke Inoue
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Publication number: 20040219566Abstract: More precise correction of global and local distortions of microarray data and correction of measurement errors caused by a difference in sensitivity between fluorescent dyes. A data standardization unit for a first process inputs gene expression intensity data from an input device, standardizes the gene expression intensity data by using grid-by-grid order statistics on the assumption that most genes are in a non-expression state, and outputs the standardized gene expression intensity data. A spot-position-based correction unit for a second process estimates a distortion depending on a spot position on a grid by grid basis by a nonparametric smoothing method and outputs gene expression intensity data whose distortion depending on the spot position has been corrected.Type: ApplicationFiled: October 30, 2003Publication date: November 4, 2004Applicants: NEC CORPORATION, MEGU OHTAKI, JAPAN BIOLOGICAL INFORMATICS CONSORTIUMInventors: Masataka Andoh, Akira Saitoh, Megu Ohtaki, Kenichi Satoh, Masahiko Nishiyama, Keiko Otani