Patents Assigned to JAPAN BLOOD PRODUCTS ORGANIZATION
  • Recombinant fibrinogen high-production line and method for producing same
    Patent number: 10208101
    Abstract: The present invention provides a recombinant strain highly producing fibrinogen which is an animal cell strain coexpressing a fibrinogen and an ?2PI and/or PAI-2, genes encoding A? chain, B? chain and ? chain of fibrinogen, a production method of a recombinant strain highly producing fibrinogen, including introducing gene(s) encoding ?2PI and/or PAI-2 into an animal cell, and coexpressing fibrinogen and ?2PI and/or PAI-2 in the animal cell, and a production method of a recombinant fibrinogen including culturing a recombinant strain highly producing fibrinogen in a medium, and recovering fibrinogen from the obtained culture.
    Type: Grant
    Filed: December 26, 2014
    Date of Patent: February 19, 2019
    Assignee: JAPAN BLOOD PRODUCTS ORGANIZATION
    Inventors: Shusei Uno, Momoko Otaki, Kouji Murakami, Shoji Ideno
  • RECOMBINANT FIBRINOGEN HIGH-PRODUCTION LINE AND METHOD FOR PRODUCING SAME
    Publication number: 20160318990
    Abstract: The present invention provides a recombinant strain highly producing fibrinogen which is an animal cell strain coexpressing a fibrinogen and an ?2PI and/or PAI-2, genes encoding A? chain, B? chain and ? chain of fibrinogen, a production method of a recombinant strain highly producing fibrinogen, including introducing gene(s) encoding ?2PI and/or PAI-2 into an animal cell, and coexpressing fibrinogen and ?2PI and/or PAI-2 in the animal cell, and a production method of a recombinant fibrinogen including culturing a recombinant strain highly producing fibrinogen in a medium, and recovering fibrinogen from the obtained culture.
    Type: Application
    Filed: December 26, 2014
    Publication date: November 3, 2016
    Applicant: JAPAN BLOOD PRODUCTS ORGANIZATION
    Inventors: Shusei UNO, Momoko OTAKI, Kouji MURAKAMI, Shoji IDENO